acebutolol-4976 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the acebutolol-4976 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
ASIC1 acid sensing (proton gated) ion channel 1
ASPH aspartate beta-hydroxylase
ASTN1 astrotactin 1
BAX BCL2-associated X protein
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP4 bone morphogenetic protein 4
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC85C coiled-coil domain containing 85C
CCNL2 cyclin L2
CDC42 cell division cycle 42
CDK13 cyclin-dependent kinase 13
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CTH cystathionine gamma-lyase
CXCR4 chemokine (C-X-C motif) receptor 4
CYHR1 cysteine/histidine-rich 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOCK6 dedicator of cytokinesis 6
DOPEY1 dopey family member 1
EGFL7 EGF-like-domain, multiple 7
EHD1 EH-domain containing 1
EPHX2 epoxide hydrolase 2, cytoplasmic
EPOR erythropoietin receptor
EPYC epiphycan
EXTL3 exostosin-like glycosyltransferase 3
FAM134B family with sequence similarity 134, member B
FGF13 fibroblast growth factor 13
FKBP10 FK506 binding protein 10, 65 kDa
FRMD8 FERM domain containing 8
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GSPT1 G1 to S phase transition 1
HAND1 heart and neural crest derivatives expressed 1
HCG4 HLA complex group 4 (non-protein coding)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HOMER3 homer scaffolding protein 3
IGKV1D-13 immunoglobulin kappa variable 1D-13
ING2 inhibitor of growth family, member 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0319L KIAA0319-like
KLF6 Kruppel-like factor 6
KLHL25 kelch-like family member 25
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K5 mitogen-activated protein kinase kinase 5
MXD3 MAX dimerization protein 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NDRG2 NDRG family member 2
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUP188 nucleoporin 188kDa
OSGIN1 oxidative stress induced growth inhibitor 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PBX2 pre-B-cell leukemia homeobox 2
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE5A phosphodiesterase 5A, cGMP-specific
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POU2F2 POU class 2 homeobox 2
PP14571 uncharacterized LOC100130449
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
QPCTL glutaminyl-peptide cyclotransferase-like
RBM3 RNA binding motif (RNP1, RRM) protein 3
RHBDD3 rhomboid domain containing 3
SAYSD1 SAYSVFN motif domain containing 1
SFRP4 secreted frizzled-related protein 4
SIDT2 SID1 transmembrane family, member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
STARD5 StAR-related lipid transfer (START) domain containing 5
STAT2 signal transducer and activator of transcription 2, 113kDa
STK16 serine/threonine kinase 16
STX7 syntaxin 7
TAT tyrosine aminotransferase
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TRIM36 tripartite motif containing 36
TUBA4B tubulin, alpha 4b
UHRF1BP1L UHRF1 binding protein 1-like
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WSB1 WD repeat and SOCS box containing 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFAND5 zinc finger, AN1-type domain 5
ZFP64 ZFP64 zinc finger protein
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACTL8 actin-like 8
ADTRP androgen-dependent TFPI-regulating protein
ALS2CL ALS2 C-terminal like
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ASCC2 activating signal cointegrator 1 complex subunit 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BATF basic leucine zipper transcription factor, ATF-like
BIRC3 baculoviral IAP repeat containing 3
C1ORF105 chromosome 1 open reading frame 105
C5ORF45 chromosome 5 open reading frame 45
CD34 CD34 molecule
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COPZ2 coatomer protein complex, subunit zeta 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DENND5B DENN/MADD domain containing 5B
DVL1 dishevelled segment polarity protein 1
DYSF dysferlin
EFNA3 ephrin-A3
ETNK2 ethanolamine kinase 2
FAM155A family with sequence similarity 155, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FGD1 FYVE, RhoGEF and PH domain containing 1
FGL1 fibrinogen-like 1
FILIP1L filamin A interacting protein 1-like
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HAMP hepcidin antimicrobial peptide
HIST1H2BO histone cluster 1, H2bo
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IDI2-AS1 IDI2 antisense RNA 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGSF1 immunoglobulin superfamily, member 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
ISG15 ISG15 ubiquitin-like modifier
JMJD4 jumonji domain containing 4
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LHX1 LIM homeobox 1
LRP5L low density lipoprotein receptor-related protein 5-like
LTC4S leukotriene C4 synthase
MRPL41 mitochondrial ribosomal protein L41
MSI1 musashi RNA-binding protein 1
MYF5 myogenic factor 5
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDE1 nudE neurodevelopment protein 1
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NIPSNAP3B nipsnap homolog 3B (C. elegans)
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PITX2 paired-like homeodomain 2
PLCD1 phospholipase C, delta 1
PMCH pro-melanin-concentrating hormone
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PTTG3P pituitary tumor-transforming 3, pseudogene
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF39 ring finger protein 39
ROM1 retinal outer segment membrane protein 1
S100A9 S100 calcium binding protein A9
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC3 syndecan 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SIX1 SIX homeobox 1
SLC10A3 solute carrier family 10, member 3
SLC12A8 solute carrier family 12, member 8
SLC41A3 solute carrier family 41, member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLIT2 slit homolog 2 (Drosophila)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYCP2 synaptonemal complex protein 2
TMEM121 transmembrane protein 121
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TOM1 target of myb1 (chicken)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBXN6 UBX domain protein 6
USB1 U6 snRNA biogenesis 1
WDR91 WD repeat domain 91
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF16 zinc finger protein 16
ZNF205 zinc finger protein 205
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862