acebutolol-6631 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

192 genes differentially expressed following the acebutolol-6631 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
AFF1 AF4/FMR2 family, member 1
AKAP5 A kinase (PRKA) anchor protein 5
ANGPT4 angiopoietin 4
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BAAT bile acid CoA:amino acid N-acyltransferase
BCL6 B-cell CLL/lymphoma 6
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
C14ORF1 chromosome 14 open reading frame 1
CADM4 cell adhesion molecule 4
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CDC25C cell division cycle 25C
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK10 cyclin-dependent kinase 10
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CYB561 cytochrome b561
DHODH dihydroorotate dehydrogenase (quinone)
DUSP1 dual specificity phosphatase 1
EFNA3 ephrin-A3
ELN elastin
ERAP2 endoplasmic reticulum aminopeptidase 2
EXPH5 exophilin 5
FAM63A family with sequence similarity 63, member A
FGFR1 fibroblast growth factor receptor 1
FLT1 fms-related tyrosine kinase 1
FOXN3 forkhead box N3
FXYD1 FXYD domain containing ion transport regulator 1
FXYD2 FXYD domain containing ion transport regulator 2
FZD9 frizzled class receptor 9
GAS7 growth arrest-specific 7
GIMAP5 GTPase, IMAP family member 5
HAND1 heart and neural crest derivatives expressed 1
HIPK3 homeodomain interacting protein kinase 3
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXA1 homeobox A1
ICAM1 intercellular adhesion molecule 1
ICAM5 intercellular adhesion molecule 5, telencephalin
IL17RB interleukin 17 receptor B
IL6 interleukin 6
ING4 inhibitor of growth family, member 4
ITGA9 integrin, alpha 9
ITPKA inositol-trisphosphate 3-kinase A
JAK3 Janus kinase 3
KANK1 KN motif and ankyrin repeat domains 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD17 potassium channel tetramerization domain containing 17
KIAA1467 KIAA1467
LIG3 ligase III, DNA, ATP-dependent
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC390998 ribosomal protein L10 pseudogene
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRN3 leucine rich repeat neuronal 3
MBNL2 muscleblind-like splicing regulator 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MUC8 mucin 8
NCF4 neutrophil cytosolic factor 4, 40kDa
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PDCD6 programmed cell death 6
PI3 peptidase inhibitor 3, skin-derived
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIDD1 p53-induced death domain protein 1
PLA2G10 phospholipase A2, group X
PODXL2 podocalyxin-like 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PQBP1 polyglutamine binding protein 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGS6 regulator of G-protein signaling 6
SCN2A sodium channel, voltage gated, type II alpha subunit
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SMC1A structural maintenance of chromosomes 1A
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA6 spermatogenesis associated 6
SPRED2 sprouty-related, EVH1 domain containing 2
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STRA6 stimulated by retinoic acid 6
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TBKBP1 TBK1 binding protein 1
TET3 tet methylcytosine dioxygenase 3
TLK1 tousled-like kinase 1
TLN2 talin 2
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TMEM231 transmembrane protein 231
TRA T cell receptor alpha locus
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSC22D4 TSC22 domain family, member 4
TSPAN32 tetraspanin 32
TUBB7P tubulin, beta 7, pseudogene
WWOX WW domain containing oxidoreductase
ZNF24 zinc finger protein 24
ZNF573 zinc finger protein 573
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ALPK1 alpha-kinase 1
ARMCX4 armadillo repeat containing, X-linked 4
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
C14ORF79 chromosome 14 open reading frame 79
C9ORF40 chromosome 9 open reading frame 40
CD79B CD79b molecule, immunoglobulin-associated beta
CDADC1 cytidine and dCMP deaminase domain containing 1
CDON cell adhesion associated, oncogene regulated
CFHR2 complement factor H-related 2
CIDEC cell death-inducing DFFA-like effector c
CRYBB2P1 crystallin, beta B2 pseudogene 1
CST1 cystatin SN
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDN dendrin
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
EN1 engrailed homeobox 1
EPHA4 EPH receptor A4
EXOC6B exocyst complex component 6B
FBXO40 F-box protein 40
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF23 fibroblast growth factor 23
FKBP10 FK506 binding protein 10, 65 kDa
GALK1 galactokinase 1
GLS2 glutaminase 2 (liver, mitochondrial)
GMIP GEM interacting protein
GPR137B G protein-coupled receptor 137B
GRAMD1C GRAM domain containing 1C
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXC13 homeobox C13
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL12B interleukin 12B
INO80D INO80 complex subunit D
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRF2 interferon regulatory factor 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA1107 KIAA1107
KIAA1456 KIAA1456
KLHL36 kelch-like family member 36
KLHL4 kelch-like family member 4
KRT20 keratin 20, type I
LIMS2 LIM and senescent cell antigen-like domains 2
LPAR4 lysophosphatidic acid receptor 4
MAGEH1 melanoma antigen family H1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MLYCD malonyl-CoA decarboxylase
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MRPL52 mitochondrial ribosomal protein L52
MTG1 mitochondrial ribosome-associated GTPase 1
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKX3-2 NK3 homeobox 2
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
NT5M 5',3'-nucleotidase, mitochondrial
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OLFML2B olfactomedin-like 2B
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE8B phosphodiesterase 8B
PID1 phosphotyrosine interaction domain containing 1
PWAR5 Prader Willi/Angelman region RNA 5
RAB33B RAB33B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SCG5 secretogranin V
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SNHG20 small nucleolar RNA host gene 20
SPATA1 spermatogenesis associated 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRD5A3 steroid 5 alpha-reductase 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STON1 stonin 1
TAOK1 TAO kinase 1
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TMSB15A thymosin beta 15a
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTN titin
TUBA4B tubulin, alpha 4b
USP27X ubiquitin specific peptidase 27, X-linked
VASH1 vasohibin 1
ZFP30 ZFP30 zinc finger protein
ZFP69B ZFP69 zinc finger protein B
ZNF268 zinc finger protein 268
ZNF446 zinc finger protein 446
ZNF862 zinc finger protein 862