acetazolamide-1686 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the acetazolamide-1686 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADAM23 ADAM metallopeptidase domain 23
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADGRG2 adhesion G protein-coupled receptor G2
ADRBK1 adrenergic, beta, receptor kinase 1
AFF1 AF4/FMR2 family, member 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARNT aryl hydrocarbon receptor nuclear translocator
BMP4 bone morphogenetic protein 4
C17ORF59 chromosome 17 open reading frame 59
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CD70 CD70 molecule
CD83 CD83 molecule
CDC25C cell division cycle 25C
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CST6 cystatin E/M
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCAF8 DDB1 and CUL4 associated factor 8
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DUSP13 dual specificity phosphatase 13
EVA1B eva-1 homolog B (C. elegans)
FAM212B family with sequence similarity 212, member B
FBXL15 F-box and leucine-rich repeat protein 15
FGFR1 fibroblast growth factor receptor 1
FH fumarate hydratase
FRS2 fibroblast growth factor receptor substrate 2
FSCN1 fascin actin-bundling protein 1
FURIN furin (paired basic amino acid cleaving enzyme)
GAMT guanidinoacetate N-methyltransferase
GLRX glutaredoxin (thioltransferase)
GOSR2 golgi SNAP receptor complex member 2
GPR153 G protein-coupled receptor 153
GPR19 G protein-coupled receptor 19
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRPR gastrin-releasing peptide receptor
GSTCD glutathione S-transferase, C-terminal domain containing
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HFE hemochromatosis
HIST1H4E histone cluster 1, H4e
HOXC5 homeobox C5
ICOSLG inducible T-cell co-stimulator ligand
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KDM4C lysine (K)-specific demethylase 4C
KIAA1456 KIAA1456
LARP7 La ribonucleoprotein domain family, member 7
LIMS2 LIM and senescent cell antigen-like domains 2
LMAN1 lectin, mannose-binding, 1
LMF1 lipase maturation factor 1
LMNB1 lamin B1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK8 mitogen-activated protein kinase 8
MCOLN3 mucolipin 3
MED25 mediator complex subunit 25
MRPL41 mitochondrial ribosomal protein L41
MYO10 myosin X
NCALD neurocalcin delta
NCOA2 nuclear receptor coactivator 2
NF1 neurofibromin 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
PAIP2B poly(A) binding protein interacting protein 2B
PAPOLA poly(A) polymerase alpha
PARD6B par-6 family cell polarity regulator beta
PBX2 pre-B-cell leukemia homeobox 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK3 polo-like kinase 3
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRPF18 pre-mRNA processing factor 18
PTCRA pre T-cell antigen receptor alpha
PVRL3 poliovirus receptor-related 3
PVT1 Pvt1 oncogene (non-protein coding)
RAB28 RAB28, member RAS oncogene family
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP3 RAN binding protein 3
RGS14 regulator of G-protein signaling 14
RYR2 ryanodine receptor 2 (cardiac)
SCGB2A2 secretoglobin, family 2A, member 2
SH3BP2 SH3-domain binding protein 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SP1 Sp1 transcription factor
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STS steroid sulfatase (microsomal), isozyme S
TBC1D5 TBC1 domain family, member 5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TH tyrosine hydroxylase
TM2D1 TM2 domain containing 1
TRIO trio Rho guanine nucleotide exchange factor
TSNAXIP1 translin-associated factor X interacting protein 1
ZFPL1 zinc finger protein-like 1
ZNF37BP zinc finger protein 37B, pseudogene
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AHDC1 AT hook, DNA binding motif, containing 1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB1 arrestin, beta 1
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L2 BCL2-like 2
BEX4 brain expressed, X-linked 4
C16ORF59 chromosome 16 open reading frame 59
C1ORF106 chromosome 1 open reading frame 106
C4ORF29 chromosome 4 open reading frame 29
C9ORF40 chromosome 9 open reading frame 40
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPJ centromere protein J
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CLCN2 chloride channel, voltage-sensitive 2
COL9A2 collagen, type IX, alpha 2
CPTP ceramide-1-phosphate transfer protein
CTNNBIP1 catenin, beta interacting protein 1
CTSC cathepsin C
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERCC5 excision repair cross-complementation group 5
FAAH fatty acid amide hydrolase
FAM155B family with sequence similarity 155, member B
FAN1 FANCD2/FANCI-associated nuclease 1
FCHSD2 FCH and double SH3 domains 2
FGD6 FYVE, RhoGEF and PH domain containing 6
FHOD1 formin homology 2 domain containing 1
FLT4 fms-related tyrosine kinase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GBP2 guanylate binding protein 2, interferon-inducible
GFOD1 glucose-fructose oxidoreductase domain containing 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIRA histone cell cycle regulator
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IQCE IQ motif containing E
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0125 KIAA0125
KIAA0894 KIAA0894 protein
LAMB3 laminin, beta 3
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAN2C1 mannosidase, alpha, class 2C, member 1
MANBA mannosidase, beta A, lysosomal
MFAP2 microfibrillar-associated protein 2
MITF microphthalmia-associated transcription factor
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MYL5 myosin, light chain 5, regulatory
MYO1D myosin ID
NDRG4 NDRG family member 4
NIPAL2 NIPA-like domain containing 2
NKRF NFKB repressing factor
PDIA3 protein disulfide isomerase family A, member 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
QTRT1 queuine tRNA-ribosyltransferase 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF121 ring finger protein 121
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD1B SET domain containing 1B
SH2D4A SH2 domain containing 4A
SIN3B SIN3 transcription regulator family member B
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMAD7 SMAD family member 7
SND1-IT1 SND1 intronic transcript 1
SOX12 SRY (sex determining region Y)-box 12
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D12 TBC1 domain family, member 12
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TKFC triokinase/FMN cyclase
TMEM120B transmembrane protein 120B
TNS2 tensin 2
TPST1 tyrosylprotein sulfotransferase 1
TRAF2 TNF receptor-associated factor 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTF2 transcription termination factor, RNA polymerase II
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZBED1 zinc finger, BED-type containing 1
ZNF652 zinc finger protein 652