acetazolamide-1850 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the acetazolamide-1850 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO10 anoctamin 10
ARG1 arginase 1
ARG2 arginase 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP9B ATPase, class II, type 9B
AXIN1 axin 1
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BAK1 BCL2-antagonist/killer 1
BRD4 bromodomain containing 4
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BTG2 BTG family, member 2
BTN2A1 butyrophilin, subfamily 2, member A1
CA1 carbonic anhydrase I
CACTIN cactin, spliceosome C complex subunit
CAMKMT calmodulin-lysine N-methyltransferase
CAV2 caveolin 2
CD59 CD59 molecule, complement regulatory protein
CDK3 cyclin-dependent kinase 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXCR3 chemokine (C-X-C motif) receptor 3
DGAT1 diacylglycerol O-acyltransferase 1
DGCR8 DGCR8 microprocessor complex subunit
DHRS11 dehydrogenase/reductase (SDR family) member 11
DIO2 deiodinase, iodothyronine, type II
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRD2 dopamine receptor D2
ELOVL5 ELOVL fatty acid elongase 5
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM65A family with sequence similarity 65, member A
FGL1 fibrinogen-like 1
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
FRS3 fibroblast growth factor receptor substrate 3
GPR182 G protein-coupled receptor 182
GPX3 glutathione peroxidase 3
GRIP2 glutamate receptor interacting protein 2
HIPK2 homeodomain interacting protein kinase 2
ICAM2 intercellular adhesion molecule 2
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IL22 interleukin 22
KIAA0100 KIAA0100
KLF13 Kruppel-like factor 13
KLF3 Kruppel-like factor 3 (basic)
KLHL28 kelch-like family member 28
KRIT1 KRIT1, ankyrin repeat containing
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL5 methyltransferase like 5
MIIP migration and invasion inhibitory protein
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPS12 mitochondrial ribosomal protein S12
MTRF1L mitochondrial translational release factor 1-like
MVD mevalonate (diphospho) decarboxylase
MYO1C myosin IC
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFRKB nuclear factor related to kappaB binding protein
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPDC1 neural proliferation, differentiation and control, 1
PAOX polyamine oxidase (exo-N4-amino)
PAPPA2 pappalysin 2
PENK proenkephalin
PIDD1 p53-induced death domain protein 1
PLSCR3 phospholipid scramblase 3
PML promyelocytic leukemia
POM121 POM121 transmembrane nucleoporin
PRDX2 peroxiredoxin 2
PRKCI protein kinase C, iota
PRR5 proline rich 5 (renal)
PRRC2B proline-rich coiled-coil 2B
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RET ret proto-oncogene
RGS1 regulator of G-protein signaling 1
RHOD ras homolog family member D
RNF122 ring finger protein 122
RUNX1 runt-related transcription factor 1
SCCPDH saccharopine dehydrogenase (putative)
SGSM3 small G protein signaling modulator 3
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPON1 spondin 1, extracellular matrix protein
SRPR signal recognition particle receptor (docking protein)
ST20 suppressor of tumorigenicity 20
SYNE1 spectrin repeat containing, nuclear envelope 1
TBC1D2 TBC1 domain family, member 2
TMCC1 transmembrane and coiled-coil domain family 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF276 zinc finger protein 276
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AIM2 absent in melanoma 2
ASB8 ankyrin repeat and SOCS box containing 8
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG2A autophagy related 2A
ATG9A autophagy related 9A
AZI2 5-azacytidine induced 2
C11ORF95 chromosome 11 open reading frame 95
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C3 complement component 3
C7ORF43 chromosome 7 open reading frame 43
CBY1 chibby homolog 1 (Drosophila)
CENPT centromere protein T
CIC capicua transcriptional repressor
CLASP1 cytoplasmic linker associated protein 1
CLEC16A C-type lectin domain family 16, member A
CTSD cathepsin D
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXORF56 chromosome X open reading frame 56
DCLRE1B DNA cross-link repair 1B
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK4 dedicator of cytokinesis 4
EDC3 enhancer of mRNA decapping 3
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FAM63A family with sequence similarity 63, member A
FANCE Fanconi anemia, complementation group E
GPR63 G protein-coupled receptor 63
HIST1H2BI histone cluster 1, H2bi
HPSE heparanase
IFI44L interferon-induced protein 44-like
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL4R interleukin 4 receptor
IMPAD1 inositol monophosphatase domain containing 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA0319L KIAA0319-like
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LIMD2 LIM domain containing 2
LY6E lymphocyte antigen 6 complex, locus E
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK3 mitogen-activated protein kinase 3
MED9 mediator complex subunit 9
MTERF4 mitochondrial transcription termination factor 4
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPM3 nucleophosmin/nucleoplasmin 3
ODF2 outer dense fiber of sperm tails 2
OTUD3 OTU deubiquitinase 3
PAQR4 progestin and adipoQ receptor family member IV
PGPEP1 pyroglutamyl-peptidase I
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PIR pirin (iron-binding nuclear protein)
PLAG1 pleiomorphic adenoma gene 1
PLS1 plastin 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRR7 proline rich 7 (synaptic)
QPCT glutaminyl-peptide cyclotransferase
RAB33B RAB33B, member RAS oncogene family
RBM42 RNA binding motif protein 42
RNF167 ring finger protein 167
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
S1PR4 sphingosine-1-phosphate receptor 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFT2D2 SFT2 domain containing 2
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLPI secretory leukocyte peptidase inhibitor
SMA4 glucuronidase, beta pseudogene
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNHG20 small nucleolar RNA host gene 20
TESK1 testis-specific kinase 1
THAP1 THAP domain containing, apoptosis associated protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM159 transmembrane protein 159
TMEM254 transmembrane protein 254
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM9 tripartite motif containing 9
UEVLD UEV and lactate/malate dehyrogenase domains
WWC2 WW and C2 domain containing 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBED8 zinc finger, BED-type containing 8
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF197 zinc finger protein 197
ZNF468 zinc finger protein 468
ZNF574 zinc finger protein 574
ZNRD1-AS1 ZNRD1 antisense RNA 1