acetazolamide-7461 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the acetazolamide-7461 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADAM22 ADAM metallopeptidase domain 22
AIM1L absent in melanoma 1-like
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMPD3 adenosine monophosphate deaminase 3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ARL15 ADP-ribosylation factor-like 15
BEGAIN brain-enriched guanylate kinase-associated
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C1ORF61 chromosome 1 open reading frame 61
C22ORF46 chromosome 22 open reading frame 46
CAPN9 calpain 9
CCNK cyclin K
CD80 CD80 molecule
CD8A CD8a molecule
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CPNE7 copine VII
CTRL chymotrypsin-like
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DOPEY2 dopey family member 2
DST dystonin
EGR1 early growth response 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPHA1 EPH receptor A1
FAM204A family with sequence similarity 204, member A
FAM212B family with sequence similarity 212, member B
FLJ11292
FLOT1 flotillin 1
GJB3 gap junction protein, beta 3, 31kDa
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB10 growth factor receptor-bound protein 10
GSAP gamma-secretase activating protein
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HLA-C major histocompatibility complex, class I, C
HUS1 HUS1 checkpoint homolog (S. pombe)
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCTD2 potassium channel tetramerization domain containing 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF12 Kruppel-like factor 12
KLHL24 kelch-like family member 24
LHX6 LIM homeobox 6
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAP4 microtubule-associated protein 4
MARK4 MAP/microtubule affinity-regulating kinase 4
MASP2 mannan-binding lectin serine peptidase 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED25 mediator complex subunit 25
MIIP migration and invasion inhibitory protein
MMP16 matrix metallopeptidase 16 (membrane-inserted)
NAAA N-acylethanolamine acid amidase
NEK1 NIMA-related kinase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OXT oxytocin/neurophysin I prepropeptide
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLXNB1 plexin B1
PML promyelocytic leukemia
PODNL1 podocan-like 1
POLG polymerase (DNA directed), gamma
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PSD4 pleckstrin and Sec7 domain containing 4
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RIN3 Ras and Rab interactor 3
RUNX1 runt-related transcription factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SCRN3 secernin 3
SLA Src-like-adaptor
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SOX15 SRY (sex determining region Y)-box 15
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRCAP Snf2-related CREBBP activator protein
STAB2 stabilin 2
STAT5B signal transducer and activator of transcription 5B
STC1 stanniocalcin 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SYT2 synaptotagmin II
TBX10 T-box 10
TEF thyrotrophic embryonic factor
TIMP3 TIMP metallopeptidase inhibitor 3
TLN2 talin 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TREX1 three prime repair exonuclease 1
UTRN utrophin
VASH2 vasohibin 2
ZBED1 zinc finger, BED-type containing 1
ZBTB44 zinc finger and BTB domain containing 44
ZNF747 zinc finger protein 747
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRD36 ankyrin repeat domain 36
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANO10 anoctamin 10
ANXA1 annexin A1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBS7 Bardet-Biedl syndrome 7
BCAS1 breast carcinoma amplified sequence 1
C11ORF30 chromosome 11 open reading frame 30
C16ORF59 chromosome 16 open reading frame 59
C1ORF109 chromosome 1 open reading frame 109
C5ORF30 chromosome 5 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
CAMKMT calmodulin-lysine N-methyltransferase
CAPN15 calpain 15
CBR4 carbonyl reductase 4
CCDC25 coiled-coil domain containing 25
CCDC88C coiled-coil domain containing 88C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC45 cell division cycle 45
CDK3 cyclin-dependent kinase 3
CENPJ centromere protein J
CEP85 centrosomal protein 85kDa
CLCN5 chloride channel, voltage-sensitive 5
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
DCAF13 DDB1 and CUL4 associated factor 13
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT3 DNA-damage-inducible transcript 3
DENND1A DENN/MADD domain containing 1A
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAL4 dynein, axonemal, light chain 4
DSE dermatan sulfate epimerase
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAN1 FANCD2/FANCI-associated nuclease 1
FBXO5 F-box protein 5
FKBP10 FK506 binding protein 10, 65 kDa
GDAP2 ganglioside induced differentiation associated protein 2
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLI3 GLI family zinc finger 3
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GPR19 G protein-coupled receptor 19
GPR87 G protein-coupled receptor 87
H2AFJ H2A histone family, member J
HAUS6 HAUS augmin-like complex, subunit 6
IFT81 intraflagellar transport 81
IL4R interleukin 4 receptor
IRF9 interferon regulatory factor 9
ITPKC inositol-trisphosphate 3-kinase C
LINC00339 long intergenic non-protein coding RNA 339
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAMLD1 mastermind-like domain containing 1
MAP1S microtubule-associated protein 1S
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MNS1 meiosis-specific nuclear structural 1
MXD3 MAX dimerization protein 3
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PER3 period circadian clock 3
PLA2G15 phospholipase A2, group XV
PRKD3 protein kinase D3
PRODH proline dehydrogenase (oxidase) 1
PTK6 protein tyrosine kinase 6
PYCRL pyrroline-5-carboxylate reductase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCOR3 REST corepressor 3
RECQL4 RecQ protein-like 4
REPS2 RALBP1 associated Eps domain containing 2
RFTN1 raftlin, lipid raft linker 1
RPAP1 RNA polymerase II associated protein 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SKA1 spindle and kinetochore associated complex subunit 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SNHG20 small nucleolar RNA host gene 20
SPIDR scaffolding protein involved in DNA repair
TESK1 testis-specific kinase 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM132A transmembrane protein 132A
TMEM180 transmembrane protein 180
TPST1 tyrosylprotein sulfotransferase 1
TSPYL2 TSPY-like 2
ULBP2 UL16 binding protein 2
WDR4 WD repeat domain 4
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF250 zinc finger protein 250
ZNF276 zinc finger protein 276
ZNF669 zinc finger protein 669
ZNHIT2 zinc finger, HIT-type containing 2