aconitine-2776 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the aconitine-2776 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
AKAP5 A kinase (PRKA) anchor protein 5
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF7IP activating transcription factor 7 interacting protein
ATG10 autophagy related 10
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAX BCL2-associated X protein
BCAN brevican
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF12 chromosome 10 open reading frame 12
CCDC71 coiled-coil domain containing 71
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CES3 carboxylesterase 3
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLDN11 claudin 11
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DDO D-aspartate oxidase
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DLC1 DLC1 Rho GTPase activating protein
DSC2 desmocollin 2
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EPHB2 EPH receptor B2
F13A1 coagulation factor XIII, A1 polypeptide
FADS2 fatty acid desaturase 2
FGB fibrinogen beta chain
FH fumarate hydratase
FUS FUS RNA binding protein
GGT1 gamma-glutamyltransferase 1
GLIPR1 GLI pathogenesis-related 1
GLRA3 glycine receptor, alpha 3
GPR182 G protein-coupled receptor 182
GREB1L growth regulation by estrogen in breast cancer-like
GYPB glycophorin B (MNS blood group)
HFE hemochromatosis
HIRA histone cell cycle regulator
HR hair growth associated
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
ITPKC inositol-trisphosphate 3-kinase C
KIAA0319L KIAA0319-like
MAN2A2 mannosidase, alpha, class 2A, member 2
MINK1 misshapen-like kinase 1
NCDN neurochondrin
NCR2 natural cytotoxicity triggering receptor 2
NPPA natriuretic peptide A
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAPPA2 pappalysin 2
PCDH17 protocadherin 17
PCDHB3 protocadherin beta 3
PITX1 paired-like homeodomain 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRR4 proline rich 4 (lacrimal)
PTHLH parathyroid hormone-like hormone
PVT1 Pvt1 oncogene (non-protein coding)
RAB6A RAB6A, member RAS oncogene family
RARA retinoic acid receptor, alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIRT5 sirtuin 5
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC16A4 solute carrier family 16, member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A16 solute carrier family 6, member 16
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLN sarcolipin
SPEG SPEG complex locus
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTB spectrin, beta, erythrocytic
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STMN1 stathmin 1
SYT13 synaptotagmin XIII
TARP TCR gamma alternate reading frame protein
TBC1D2 TBC1 domain family, member 2
TBX19 T-box 19
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THAP9 THAP domain containing 9
TK2 thymidine kinase 2, mitochondrial
TRAK1 trafficking protein, kinesin binding 1
TRIM36 tripartite motif containing 36
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF134 zinc finger protein 134
ZNF37BP zinc finger protein 37B, pseudogene
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGRG2 adhesion G protein-coupled receptor G2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALPK1 alpha-kinase 1
AMPD2 adenosine monophosphate deaminase 2
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C19ORF73 chromosome 19 open reading frame 73
C8ORF44 chromosome 8 open reading frame 44
C8ORF60 chromosome 8 open reading frame 60
CCDC132 coiled-coil domain containing 132
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDKL3 cyclin-dependent kinase-like 3
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNR2 cannabinoid receptor 2 (macrophage)
CPPED1 calcineurin-like phosphoesterase domain containing 1
CXADR coxsackie virus and adenovirus receptor
DGAT1 diacylglycerol O-acyltransferase 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ETAA1 Ewing tumor-associated antigen 1
EXO5 exonuclease 5
F8 coagulation factor VIII, procoagulant component
FAM189A2 family with sequence similarity 189, member A2
FAM212B family with sequence similarity 212, member B
FBXL6 F-box and leucine-rich repeat protein 6
FOXN2 forkhead box N2
GFI1 growth factor independent 1 transcription repressor
GLB1L galactosidase, beta 1-like
GLB1L2 galactosidase, beta 1-like 2
GMEB1 glucocorticoid modulatory element binding protein 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL22 interleukin 22
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCTD7 potassium channel tetramerization domain containing 7
KIAA1107 KIAA1107
KRI1 KRI1 homolog (S. cerevisiae)
LHX1 LIM homeobox 1
LY6D lymphocyte antigen 6 complex, locus D
LYRM9 LYR motif containing 9
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MANBA mannosidase, beta A, lysosomal
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEIS2 Meis homeobox 2
MFSD11 major facilitator superfamily domain containing 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
OLFML2A olfactomedin-like 2A
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHA6 protocadherin alpha 6
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PEX26 peroxisomal biogenesis factor 26
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAB3D RAB3D, member RAS oncogene family
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAV1 salvador family WW domain containing protein 1
SCN1B sodium channel, voltage gated, type I beta subunit
SHARPIN SHANK-associated RH domain interactor
SIK1 salt-inducible kinase 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SREK1IP1 SREK1-interacting protein 1
STAG3 stromal antigen 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STBD1 starch binding domain 1
STK16 serine/threonine kinase 16
STX1A syntaxin 1A (brain)
TBC1D17 TBC1 domain family, member 17
TBC1D19 TBC1 domain family, member 19
TCP10 t-complex 10
TMEM120B transmembrane protein 120B
TRABD TraB domain containing
TRAIP TRAF interacting protein
TSPYL2 TSPY-like 2
TTC9 tetratricopeptide repeat domain 9
VASH1 vasohibin 1
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC18 zinc finger, DHHC-type containing 18
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF428 zinc finger protein 428
ZNF767P zinc finger family member 767, pseudogene
ZNF862 zinc finger protein 862
ZSCAN2 zinc finger and SCAN domain containing 2