acromegaly Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb. (Human Disease Ontology, DOID_2449)
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Genes

89 genes co-occuring with the disease acromegaly in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IGF1 insulin-like growth factor 1 (somatomedin C) 3.41026
SST somatostatin 3.02891
GHRH growth hormone releasing hormone 2.61478
TRH thyrotropin-releasing hormone 2.3107
PRL prolactin 2.23779
GHR growth hormone receptor 2.19084
GH1 growth hormone 1 1.83727
INS insulin 1.76683
IGFBP3 insulin-like growth factor binding protein 3 1.72912
AIP aryl hydrocarbon receptor interacting protein 1.70588
POMC proopiomelanocortin 1.62247
SSTR5 somatostatin receptor 5 1.54982
SSTR2 somatostatin receptor 2 1.46803
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.46627
MEN1 multiple endocrine neoplasia I 1.41139
GNAS GNAS complex locus 1.31581
GHDC GH3 domain containing 1.28479
GCG glucagon 1.11856
IGFBP1 insulin-like growth factor binding protein 1 1.08621
SSTR1 somatostatin receptor 1 1.05639
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.01132
GHRL ghrelin/obestatin prepropeptide 1.00246
SNED1 sushi, nidogen and EGF-like domains 1 0.977165
VIP vasoactive intestinal peptide 0.929173
CRH corticotropin releasing hormone 0.922561
GAST gastrin 0.89623
BGLAP bone gamma-carboxyglutamate (gla) protein 0.879014
TRHR thyrotropin-releasing hormone receptor 0.856087
IGF2 insulin-like growth factor 2 0.834788
GHRHR growth hormone releasing hormone receptor 0.818796
LIN7A lin-7 homolog A (C. elegans) 0.802385
SSTR3 somatostatin receptor 3 0.796642
GH2 growth hormone 2 0.770027
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.735838
SCG5 secretogranin V 0.709169
LEP leptin 0.706754
PPY pancreatic polypeptide 0.690694
GAL galanin/GMAP prepropeptide 0.686291
TSHB thyroid stimulating hormone, beta 0.670732
PTH parathyroid hormone 0.663181
SSTR4 somatostatin receptor 4 0.642221
GHSR growth hormone secretagogue receptor 0.60186
ESRP1 epithelial splicing regulatory protein 1 0.561004
REN renin 0.524202
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.51534
KL klotho 0.508041
CALCA calcitonin-related polypeptide alpha 0.490835
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.489311
DRD2 dopamine receptor D2 0.463905
VPREB1 pre-B lymphocyte 1 0.451831
CCDC34 coiled-coil domain containing 34 0.442042
CCK cholecystokinin 0.437906
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.424014
ALPPL2 alkaline phosphatase, placental-like 2 0.410161
ALPP alkaline phosphatase, placental 0.409787
ALPL alkaline phosphatase, liver/bone/kidney 0.40904
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.385936
MLN motilin 0.381852
INSR insulin receptor 0.375179
MRGPRX2 MAS-related GPR, member X2 0.353763
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.349349
ADCY2 adenylate cyclase 2 (brain) 0.331391
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.296211
AVP arginine vasopressin 0.293334
PRLR prolactin receptor 0.282582
CHGA chromogranin A 0.275089
SHBG sex hormone-binding globulin 0.273308
IGFBP5 insulin-like growth factor binding protein 5 0.24715
STAT5B signal transducer and activator of transcription 5B 0.241546
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.234225
F10 coagulation factor X 0.232142
NPS neuropeptide S 0.228333
RAB18 RAB18, member RAS oncogene family 0.225917
LPXN leupaxin 0.218374
CERS4 ceramide synthase 4 0.217352
CORT cortistatin 0.208245
SYP synaptophysin 0.204593
CETP cholesteryl ester transfer protein, plasma 0.202618
SRL sarcalumenin 0.190786
AVPR1B arginine vasopressin receptor 1B 0.183248
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.173832
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.169571
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.168381
LPL lipoprotein lipase 0.166319
GIP gastric inhibitory polypeptide 0.163523
CRP C-reactive protein, pentraxin-related 0.162908
DSC3 desmocollin 3 0.160203
AASS aminoadipate-semialdehyde synthase 0.159658
SHOX short stature homeobox 0.158778