actin filament Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. (Gene Ontology, GO_0005884)
External Link http://amigo.geneontology.org/amigo/term/GO:0005884
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Genes

52 proteins localized to the actin filament cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ACKR2 atypical chemokine receptor 2
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AIF1 allograft inflammatory factor 1
AIF1L allograft inflammatory factor 1-like
AMOT angiomotin
ANKRD26 ankyrin repeat domain 26
APC2 adenomatosis polyposis coli 2
ARHGAP6 Rho GTPase activating protein 6
BIN3 bridging integrator 3
CAPZB capping protein (actin filament) muscle Z-line, beta
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CORO1B coronin, actin binding protein, 1B
CTTN cortactin
DFNB31 deafness, autosomal recessive 31
DMTN dematin actin binding protein
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EZR ezrin
FKBP15 FK506 binding protein 15, 133kDa
FLNA filamin A, alpha
FMN1 formin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS2 growth arrest-specific 2
GAS7 growth arrest-specific 7
GCK glucokinase (hexokinase 4)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
HCK HCK proto-oncogene, Src family tyrosine kinase
IQGAP1 IQ motif containing GTPase activating protein 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MARK2 MAP/microtubule affinity-regulating kinase 2
MYO1B myosin IB
MYO5A myosin VA (heavy chain 12, myoxin)
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RCSD1 RCSD domain containing 1
RHOQ ras homolog family member Q
SH2B2 SH2B adaptor protein 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TEK TEK tyrosine kinase, endothelial
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TSC1 tuberous sclerosis 1
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
WDR1 WD repeat domain 1
WIPF1 WAS/WASL interacting protein family, member 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
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