actinomycin-d Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

80 genes differentially expressed following the actinomycin-d small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
NXPH4 neurexophilin 4 4.29516
RPS10 ribosomal protein S10 4.13467
RPL23A ribosomal protein L23a 4.11701
RPS4Y1 ribosomal protein S4, Y-linked 1 3.9642
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 3.78173
RPL9 ribosomal protein L9 3.72254
RPS18 ribosomal protein S18 3.69248
CEP70 centrosomal protein 70kDa 3.65373
RPL39 ribosomal protein L39 3.52741
ARHGAP44 Rho GTPase activating protein 44 3.42111
RPL30 ribosomal protein L30 3.19649
CFL1 cofilin 1 (non-muscle) 3.18756
MAOA monoamine oxidase A 3.14705
NOTCH4 notch 4 3.13796
RPS4X ribosomal protein S4, X-linked 3.12281
CRELD1 cysteine-rich with EGF-like domains 1 3.11474
RPL41 ribosomal protein L41 3.11063
CIB2 calcium and integrin binding family member 2 3.10381
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 3.07196
CTSV cathepsin V 3.06991
RPS24 ribosomal protein S24 3.06652
ZNF816 zinc finger protein 816 3.03653
ST14 suppression of tumorigenicity 14 (colon carcinoma) 3.00804

decreased expression

Symbol Name Standardized Value
TMEM11 transmembrane protein 11 -4.80699
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -4.35807
TBP TATA box binding protein -4.25193
CDC25A cell division cycle 25A -4.19465
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -4.08166
JMJD6 jumonji domain containing 6 -4.04371
GEMIN4 gem (nuclear organelle) associated protein 4 -4.03707
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.01428
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.98739
FOSL1 FOS-like antigen 1 -3.95952
TTC4 tetratricopeptide repeat domain 4 -3.90091
SAV1 salvador family WW domain containing protein 1 -3.78897
CSRP1 cysteine and glycine-rich protein 1 -3.76105
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -3.6635
KIF23 kinesin family member 23 -3.65369
PCGF1 polycomb group ring finger 1 -3.63241
CHTOP chromatin target of PRMT1 -3.60234
ZNF217 zinc finger protein 217 -3.56283
BCOR BCL6 corepressor -3.54192
MRM3 mitochondrial rRNA methyltransferase 3 -3.5297
UTP25 UTP25 small subunit processome component -3.39186
NRIP1 nuclear receptor interacting protein 1 -3.38012
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.37771
NGDN neuroguidin, EIF4E binding protein -3.36154
METTL18 methyltransferase like 18 -3.33809
GSPT2 G1 to S phase transition 2 -3.33518
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -3.33416
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -3.32113
SNW1 SNW domain containing 1 -3.31409
NOL11 nucleolar protein 11 -3.3043
PARP2 poly (ADP-ribose) polymerase 2 -3.28997
ZNF202 zinc finger protein 202 -3.24898
CHERP calcium homeostasis endoplasmic reticulum protein -3.23379
NXT1 nuclear transport factor 2-like export factor 1 -3.2277
UBE2C ubiquitin-conjugating enzyme E2C -3.21556
RNF4 ring finger protein 4 -3.21369
PELO pelota homolog (Drosophila) -3.17568
SEC24B SEC24 family member B -3.16683
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.16237
CREBBP CREB binding protein -3.12324
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -3.1135
MTPAP mitochondrial poly(A) polymerase -3.10654
CDK7 cyclin-dependent kinase 7 -3.10544
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -3.10129
DUSP7 dual specificity phosphatase 7 -3.09965
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -3.09584
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -3.09326
KIF18A kinesin family member 18A -3.0932
PHF20 PHD finger protein 20 -3.08036
FOXJ3 forkhead box J3 -3.06989
NCAPH non-SMC condensin I complex, subunit H -3.06856
KIF2A kinesin heavy chain member 2A -3.06413
HJURP Holliday junction recognition protein -3.05426
PLK4 polo-like kinase 4 -3.04135
BRD1 bromodomain containing 1 -3.02538
NUP62 nucleoporin 62kDa -3.02406
ZNF574 zinc finger protein 574 -3.01575