acute hepatic failure Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver. (Human Phenotype Ontology, HP_0006554)
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14 genes associated with the acute hepatic failure phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
CYC1 cytochrome c-1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
GFM1 G elongation factor, mitochondrial 1
HADH hydroxyacyl-CoA dehydrogenase
HLA-B major histocompatibility complex, class I, B
JAK2 Janus kinase 2
MEFV Mediterranean fever
MPV17 MpV17 mitochondrial inner membrane protein
PORCN porcupine homolog (Drosophila)
SH2D1A SH2 domain containing 1A
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)