acute myeloid leukemia Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. (Human Disease Ontology, DOID_9119)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0004808
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Genes

23 genes associated with the acute myeloid leukemia phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
BRCA2 breast cancer 2, early onset
CBFB core-binding factor, beta subunit
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DKC1 dyskeratosis congenita 1, dyskerin
ETV6 ets variant 6
FLT3 fms-related tyrosine kinase 3
GFI1 growth factor independent 1 transcription repressor
GMPS guanine monphosphate synthase
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2A lysine (K)-specific methyltransferase 2A
LPP LIM domain containing preferred translocation partner in lipoma
MLF1 myeloid leukemia factor 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSD1 nuclear receptor binding SET domain protein 1
NUP214 nucleoporin 214kDa
PICALM phosphatidylinositol binding clathrin assembly protein
RUNX1 runt-related transcription factor 1
SBDS Shwachman-Bodian-Diamond syndrome
SH3GL1 SH3-domain GRB2-like 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
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