adenoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.|A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract. (Experimental Factor Ontology, EFO_0000232)
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Genes

316 genes co-occuring with the biological term adenoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIP aryl hydrocarbon receptor interacting protein
AKAP13 A kinase (PRKA) anchor protein 13
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
ALOX15B arachidonate 15-lipoxygenase, type B
ALOX5 arachidonate 5-lipoxygenase
ALPK2 alpha-kinase 2
AMACR alpha-methylacyl-CoA racemase
APC adenomatous polyposis coli
AR androgen receptor
ARG2 arginase 2
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AXIN2 axin 2
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDKRB1 bradykinin receptor B1
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CCR6 chemokine (C-C motif) receptor 6
CD24 CD24 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDX2 caudal type homeobox 2
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CGB chorionic gonadotropin, beta polypeptide
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
CRP C-reactive protein, pentraxin-related
CRTC1 CREB regulated transcription coactivator 1
CRTC3 CREB regulated transcription coactivator 3
CSNK1D casein kinase 1, delta
CTBP1 C-terminal binding protein 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSL cathepsin L
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DCC DCC netrin 1 receptor
DDIT3 DNA-damage-inducible transcript 3
DDR1 discoidin domain receptor tyrosine kinase 1
DEFA6 defensin, alpha 6, Paneth cell-specific
DIO1 deiodinase, iodothyronine, type I
DIO2 deiodinase, iodothyronine, type II
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EPCAM epithelial cell adhesion molecule
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZR ezrin
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF2 fibroblast growth factor 2 (basic)
FGFR4 fibroblast growth factor receptor 4
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FRZB frizzled-related protein
FSCN1 fascin actin-bundling protein 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD6 frizzled class receptor 6
GDF15 growth differentiation factor 15
GDF5 growth differentiation factor 5
GH1 growth hormone 1
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GLI1 GLI family zinc finger 1
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPC3 glypican 3
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HES5 hes family bHLH transcription factor 5
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL11 interleukin 11
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INHA inhibin, alpha
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
KL klotho
KLK10 kallikrein-related peptidase 10
KLK14 kallikrein-related peptidase 14
KLK7 kallikrein-related peptidase 7
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LHCGR luteinizing hormone/choriogonadotropin receptor
LPAR1 lysophosphatidic acid receptor 1
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRRC4 leucine rich repeat containing 4
MAML2 mastermind-like 2 (Drosophila)
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK8 mitogen-activated protein kinase 8
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MICA MHC class I polypeptide-related sequence A
MIR135B microRNA 135b
MIR17 microRNA 17
MIR182 microRNA 182
MIR191 microRNA 191
MIR21 microRNA 21
MIR24-1 microRNA 24-1
MIR503 microRNA 503
MIR92A1 microRNA 92a-1
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MT1F metallothionein 1F
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC1 mucin 1, cell surface associated
MUC6 mucin 6, oligomeric mucus/gel-forming
MUTYH mutY homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFE2L2 nuclear factor, erythroid 2-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NNAT neuronatin
NOS2 nitric oxide synthase 2, inducible
NOX1 NADPH oxidase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
OGG1 8-oxoguanine DNA glycosylase
OGN osteoglycin
PAX2 paired box 2
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PGR progesterone receptor
PHB prohibitin
PLAG1 pleiomorphic adenoma gene 1
PLEC plectin
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNKP polynucleotide kinase 3'-phosphatase
POMC proopiomelanocortin
POU5F1 POU class 5 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PRDX1 peroxiredoxin 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCE protein kinase C, epsilon
PRL prolactin
PROM1 prominin 1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBL1 retinoblastoma-like 1
REG4 regenerating islet-derived family, member 4
RET ret proto-oncogene
RNU6-1 RNA, U6 small nuclear 1
RXRA retinoid X receptor, alpha
S100A1 S100 calcium binding protein A1
S100P S100 calcium binding protein P
SCGN secretagogin, EF-hand calcium binding protein
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SFRP2 secreted frizzled-related protein 2
SHH sonic hedgehog
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT2 slit homolog 2 (Drosophila)
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SNAP23 synaptosomal-associated protein, 23kDa
SNAP25 synaptosomal-associated protein, 25kDa
SPDEF SAM pointed domain containing ETS transcription factor
SPN sialophorin
SRPX2 sushi-repeat containing protein, X-linked 2
SRSF1 serine/arginine-rich splicing factor 1
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR5 somatostatin receptor 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
STX1A syntaxin 1A (brain)
TCF4 transcription factor 4
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
TGFB1 transforming growth factor, beta 1
TMPRSS15 transmembrane protease, serine 15
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNXB tenascin XB
TP53 tumor protein p53
TP73 tumor protein p73
TPO thyroid peroxidase
TPX2 TPX2, microtubule-associated
TRHR thyrotropin-releasing hormone receptor
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSHR thyroid stimulating hormone receptor
TSPO translocator protein (18kDa)
TWIST1 twist family bHLH transcription factor 1
TXNRD1 thioredoxin reductase 1
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UTS2R urotensin 2 receptor
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT4 wingless-type MMTV integration site family, member 4
WNT6 wingless-type MMTV integration site family, member 6
XPC xeroderma pigmentosum, complementation group C
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF331 zinc finger protein 331