adenomas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.|A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract. (Experimental Factor Ontology, EFO_0000232)
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Genes

309 genes co-occuring with the biological term adenomas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACAN aggrecan
ADM adrenomedullin
AIP aryl hydrocarbon receptor interacting protein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15 arachidonate 15-lipoxygenase
AMACR alpha-methylacyl-CoA racemase
APC adenomatous polyposis coli
AR androgen receptor
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
BAG1 BCL2-associated athanogene
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BSG basigin (Ok blood group)
CA9 carbonic anhydrase IX
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCKBR cholecystokinin B receptor
CCNB2 cyclin B2
CCND1 cyclin D1
CCND3 cyclin D3
CD1A CD1a molecule
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CD68 CD68 molecule
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH13 cadherin 13
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDX2 caudal type homeobox 2
CGB chorionic gonadotropin, beta polypeptide
CHGA chromogranin A
CLDN1 claudin 1
CLDN2 claudin 2
CLDN7 claudin 7
COL11A1 collagen, type XI, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CREB1 cAMP responsive element binding protein 1
CREB3L3 cAMP responsive element binding protein 3-like 3
CRP C-reactive protein, pentraxin-related
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTSE cathepsin E
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCC DCC netrin 1 receptor
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFA4 defensin, alpha 4, corticostatin
DIO1 deiodinase, iodothyronine, type I
DIO2 deiodinase, iodothyronine, type II
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRP1 epithelial splicing regulatory protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP6 fatty acid binding protein 6, ileal
FAS Fas cell surface death receptor
FGFR4 fibroblast growth factor receptor 4
FHL5 four and a half LIM domains 5
FOLR1 folate receptor 1 (adult)
FOXL2 forkhead box L2
FSCN1 fascin actin-bundling protein 1
FSHR follicle stimulating hormone receptor
FTO fat mass and obesity associated
GADD45G growth arrest and DNA-damage-inducible, gamma
GAL galanin/GMAP prepropeptide
GATA6 GATA binding protein 6
GDF5 growth differentiation factor 5
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GLB1 galactosidase, beta 1
GNAS GNAS complex locus
GPR182 G protein-coupled receptor 182
GREM1 gremlin 1, DAN family BMP antagonist
GRP gastrin-releasing peptide
GSTP1 glutathione S-transferase pi 1
GUCY2C guanylate cyclase 2C
GUK1 guanylate kinase 1
HAMP hepcidin antimicrobial peptide
HCRTR1 hypocretin (orexin) receptor 1
HCRTR2 hypocretin (orexin) receptor 2
HDAC2 histone deacetylase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLTF helicase-like transcription factor
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HNF1A HNF1 homeobox A
HPSE heparanase
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL17RA interleukin 17 receptor A
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INS insulin
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT20 keratin 20, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LHCGR luteinizing hormone/choriogonadotropin receptor
LPAR1 lysophosphatidic acid receptor 1
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCM2 minichromosome maintenance complex component 2
MEG3 maternally expressed 3 (non-protein coding)
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR107 microRNA 107
MIR122 microRNA 122
MIR139 microRNA 139
MIR181B1 microRNA 181b-1
MIR181B2 microRNA 181b-2
MIR21 microRNA 21
MIR335 microRNA 335
MIR371A microRNA 371a
MIR483 microRNA 483
MIR493 microRNA 493
MIR512-1 microRNA 512-1
MIR517A microRNA 517a
MIR519A1 microRNA 519a-1
MIR675 microRNA 675
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSH2 mutS homolog 2
MST1R macrophage stimulating 1 receptor
MSX1 msh homeobox 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUTYH mutY homolog
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCOR1 nuclear receptor corepressor 1
NES nestin
NEUROD1 neuronal differentiation 1
NFE2L2 nuclear factor, erythroid 2-like 2
NKX2-1 NK2 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH1 notch 1
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
NTSR2 neurotensin receptor 2
OGG1 8-oxoguanine DNA glycosylase
PAX2 paired box 2
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PDE11A phosphodiesterase 11A
PECAM1 platelet/endothelial cell adhesion molecule 1
PELP1 proline, glutamate and leucine rich protein 1
PIAS1 protein inhibitor of activated STAT, 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PITX2 paired-like homeodomain 2
PKM pyruvate kinase, muscle
PLAG1 pleiomorphic adenoma gene 1
PLAGL1 pleiomorphic adenoma gene-like 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POU1F1 POU class 1 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PROM1 prominin 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTTG1 pituitary tumor-transforming 1
RARA retinoic acid receptor, alpha
RASSF3 Ras association (RalGDS/AF-6) domain family member 3
RB1 retinoblastoma 1
RERG RAS-like, estrogen-regulated, growth inhibitor
RET ret proto-oncogene
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SCG3 secretogranin III
SCGB1D2 secretoglobin, family 1D, member 2
SCGN secretagogin, EF-hand calcium binding protein
SHH sonic hedgehog
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SMAD4 SMAD family member 4
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SOCS1 suppressor of cytokine signaling 1
SORD sorbitol dehydrogenase
SORT1 sortilin 1
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR3 somatostatin receptor 3
SSTR4 somatostatin receptor 4
SSTR5 somatostatin receptor 5
STAR steroidogenic acute regulatory protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STS steroid sulfatase (microsomal), isozyme S
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SYP synaptophysin
TARBP2 TAR (HIV-1) RNA binding protein 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
THADA thyroid adenoma associated
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THRA thyroid hormone receptor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TRHR thyrotropin-releasing hormone receptor
TSHR thyroid stimulating hormone receptor
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
USP8 ubiquitin specific peptidase 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VSNL1 visinin-like 1
WIF1 WNT inhibitory factor 1
WNT4 wingless-type MMTV integration site family, member 4
WT1 Wilms tumor 1
ZAR1 zygote arrest 1