adiposity Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An eating-related disorder in which excess body fat has accumulated to such an extent that health may be negatively affected. It is commonly defined as a body mass index (weight divided by height squared) of 30 kg/m2 or higher.|A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). (Experimental Factor Ontology, EFO_0001073)
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Genes

125 genes co-occuring with the biological term adiposity in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADRB3 adrenoceptor beta 3
AKR1C1 aldo-keto reductase family 1, member C1
AMH anti-Mullerian hormone
ANGPTL2 angiopoietin-like 2
AOC3 amine oxidase, copper containing 3
APOE apolipoprotein E
APOM apolipoprotein M
AR androgen receptor
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BGLAP bone gamma-carboxyglutamate (gla) protein
C5AR1 complement component 5a receptor 1
C5AR2 complement component 5a receptor 2
CCL3 chemokine (C-C motif) ligand 3
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CES1 carboxylesterase 1
CNR1 cannabinoid receptor 1 (brain)
COPA coatomer protein complex, subunit alpha
CPT1A carnitine palmitoyltransferase 1A (liver)
CRP C-reactive protein, pentraxin-related
CRTC3 CREB regulated transcription coactivator 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAAH fatty acid amide hydrolase
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FGF21 fibroblast growth factor 21
FNDC5 fibronectin type III domain containing 5
FST follistatin
FTO fat mass and obesity associated
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
HBA1 hemoglobin, alpha 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IL12B interleukin 12B
IL6 interleukin 6
INS insulin
INSIG2 insulin induced gene 2
INSL3 insulin-like 3 (Leydig cell)
IRS1 insulin receptor substrate 1
ISL1 ISL LIM homeobox 1
ITLN1 intelectin 1 (galactofuranose binding)
KCTD15 potassium channel tetramerization domain containing 15
LEP leptin
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LIPC lipase, hepatic
LMNA lamin A/C
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYPLAL1 lysophospholipase-like 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MMP9 matrix metallopeptidase 9
MSRA methionine sulfoxide reductase A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAMPT nicotinamide phosphoribosyltransferase
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUCB2 nucleobindin 2
OPRM1 opioid receptor, mu 1
OR7D4 olfactory receptor, family 7, subfamily D, member 4
OR7G3 olfactory receptor, family 7, subfamily G, member 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE8B phosphodiesterase 8B
POMC proopiomelanocortin
PON3 paraoxonase 3
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRRC2A proline-rich coiled-coil 2A
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBP4 retinol binding protein 4, plasma
RETN resistin
RNF10 ring finger protein 10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC16B SEC16 homolog B (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH2B1 SH2B adaptor protein 1
SIM1 single-minded family bHLH transcription factor 1
TAS2R38 taste receptor, type 2, member 38
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNMD tenomodulin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDTC1 WD and tetratricopeptide repeats 1
WNT10B wingless-type MMTV integration site family, member 10B