afatinib Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer. (Chemical Entities of Biological Interest Ontology, CHEBI_61390)
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Genes

4 genes co-occuring with the biological term afatinib in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
EGFR epidermal growth factor receptor
MCL1 myeloid cell leukemia 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
RAB11A RAB11A, member RAS oncogene family