afp Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description alpha-fetoprotein|This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 174)
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Genes

35 genes co-occuring with the biological term afp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AFP alpha-fetoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALPP alkaline phosphatase, placental
APC adenomatous polyposis coli
AREG amphiregulin
CCL20 chemokine (C-C motif) ligand 20
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHKA choline kinase alpha
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPCAM epithelial cell adhesion molecule
F2 coagulation factor II (thrombin)
GJA1 gap junction protein, alpha 1, 43kDa
GPBAR1 G protein-coupled bile acid receptor 1
GPC3 glypican 3
IGF1 insulin-like growth factor 1 (somatomedin C)
LHX4 LIM homeobox 4
MACC1 metastasis associated in colon cancer 1
MIR29A microRNA 29a
MUC16 mucin 16, cell surface associated
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RND3 Rho family GTPase 3
SALL4 spalt-like transcription factor 4
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPP1 secreted phosphoprotein 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53 tumor protein p53
TP73 tumor protein p73
TRIM26 tripartite motif containing 26
VEGFA vascular endothelial growth factor A
YAP1 Yes-associated protein 1
ZHX2 zinc fingers and homeoboxes 2