agammaglobulinemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A B cell deficiency that is caused by a reduction in all types of gamma globulins. (Human Disease Ontology, DOID_2583)
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Genes

277 genes co-occuring with the disease agammaglobulinemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BTK Bruton agammaglobulinemia tyrosine kinase 3.17403
CD79A CD79a molecule, immunoglobulin-associated alpha 2.15665
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.06442
SH2D1A SH2 domain containing 1A 1.96192
PLEK pleckstrin 1.77677
CD19 CD19 molecule 1.77225
CD27 CD27 molecule 1.74688
CD40LG CD40 ligand 1.7396
CXCR4 chemokine (C-X-C motif) receptor 4 1.69678
CD4 CD4 molecule 1.64936
ITK IL2-inducible T-cell kinase 1.58983
TXK TXK tyrosine kinase 1.46188
BMX BMX non-receptor tyrosine kinase 1.44035
CAMLG calcium modulating ligand 1.42586
BLNK B-cell linker 1.4057
CD40 CD40 molecule, TNF receptor superfamily member 5 1.37817
CD38 CD38 molecule 1.27475
AICDA activation-induced cytidine deaminase 1.26603
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 1.26168
TEC tec protein tyrosine kinase 1.19704
SPRYD3 SPRY domain containing 3 1.15112
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.15112
TLR9 toll-like receptor 9 1.149
NT5E 5'-nucleotidase, ecto (CD73) 1.13374
MSH5 mutS homolog 5 1.12319
CD79B CD79b molecule, immunoglobulin-associated beta 1.09461
LRRC8A leucine rich repeat containing 8 family, member A 1.09167
IL2 interleukin 2 1.07278
B3GAT1 beta-1,3-glucuronyltransferase 1 1.06396
BCR breakpoint cluster region 1.05597
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.05261
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 1.04377
CXCL12 chemokine (C-X-C motif) ligand 12 0.999924
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.97044
CD81 CD81 molecule 0.9696
LRRC8E leucine rich repeat containing 8 family, member E 0.967083
ZBTB24 zinc finger and BTB domain containing 24 0.922149
CD69 CD69 molecule 0.894589
SYK spleen tyrosine kinase 0.858952
LYN LYN proto-oncogene, Src family tyrosine kinase 0.858134
PREB prolactin regulatory element binding 0.849536
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 0.813052
CD5 CD5 molecule 0.808539
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.801564
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.782707
ORC4 origin recognition complex, subunit 4 0.763494
SP110 SP110 nuclear body protein 0.758601
IL21 interleukin 21 0.757786
UNG uracil-DNA glycosylase 0.727333
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.722077
CD86 CD86 molecule 0.717232
TCN2 transcobalamin II 0.712796
CFP complement factor properdin 0.700321
KRT84 keratin 84, type II 0.690293
RAG1 recombination activating gene 1 0.674315
TMPO thymopoietin 0.666358
CARD11 caspase recruitment domain family, member 11 0.6608
POU2AF1 POU class 2 associating factor 1 0.649323
IGHV3-9 immunoglobulin heavy variable 3-9 0.648533
TNF tumor necrosis factor 0.642615
CD70 CD70 molecule 0.640251
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.636708
TLR7 toll-like receptor 7 0.636315
IGLL1 immunoglobulin lambda-like polypeptide 1 0.633956
ALB albumin 0.630813
SLAMF1 signaling lymphocytic activation molecule family member 1 0.62728
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 0.621008
CCR7 chemokine (C-C motif) receptor 7 0.596792
PTPRC protein tyrosine phosphatase, receptor type, C 0.589779
CD84 CD84 molecule 0.589779
FOXP3 forkhead box P3 0.585497
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.585497
STXBP2 syntaxin binding protein 2 0.582773
IL4 interleukin 4 0.580439
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.575383
SIGLEC10 sialic acid binding Ig-like lectin 10 0.566831
RAG2 recombination activating gene 2 0.565666
ICOS inducible T-cell co-stimulator 0.558285
C4A complement component 4A (Rodgers blood group) 0.557509
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.550522
CD180 CD180 molecule 0.546256
PAX5 paired box 5 0.545481
VAV1 vav 1 guanine nucleotide exchange factor 0.537731
UNC13D unc-13 homolog D (C. elegans) 0.535409
OR2H2 olfactory receptor, family 2, subfamily H, member 2 0.526132
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.51842
WAS Wiskott-Aldrich syndrome 0.499997
EPHB6 EPH receptor B6 0.499614
ALG12 ALG12, alpha-1,6-mannosyltransferase 0.489311
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.481705
JAK3 Janus kinase 3 0.477909
HCK HCK proto-oncogene, Src family tyrosine kinase 0.463905
ANKRD54 ankyrin repeat domain 54 0.460129
CD83 CD83 molecule 0.458619
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.458241
CD24 CD24 molecule 0.456355
TSKU tsukushi, small leucine rich proteoglycan 0.45447
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.451078
ICOSLG inducible T-cell co-stimulator ligand 0.446558
PRF1 perforin 1 (pore forming protein) 0.440914
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.440162
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.438658
FYN FYN proto-oncogene, Src family tyrosine kinase 0.437906
PAX2 paired box 2 0.434899
STX11 syntaxin 11 0.433021
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.431894
GTF2I general transcription factor IIi 0.419517
ADA adenosine deaminase 0.415024
RPS19BP1 ribosomal protein S19 binding protein 1 0.410161
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.407172
CD247 CD247 molecule 0.405305
IGHV4-39 immunoglobulin heavy variable 4-39 0.399707
BCLAF1 BCL2-associated transcription factor 1 0.398589
TRHDE thyrotropin-releasing hormone degrading enzyme 0.391513
TCF3 transcription factor 3 0.389281
DOCK8 dedicator of cytokinesis 8 0.386679
TLR4 toll-like receptor 4 0.385936
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.384822
CD58 CD58 molecule 0.374068
CD34 CD34 molecule 0.374068
NHEJ1 nonhomologous end-joining factor 1 0.373328
IL21R interleukin 21 receptor 0.364824
IFITM1 interferon induced transmembrane protein 1 0.360026
HLA-A major histocompatibility complex, class I, A 0.359657
CECR1 cat eye syndrome chromosome region, candidate 1 0.352659
NCAM1 neural cell adhesion molecule 1 0.352659
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.351923
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.351187
HN1L hematological and neurological expressed 1-like 0.347879
LCK LCK proto-oncogene, Src family tyrosine kinase 0.343106
ADRBK2 adrenergic, beta, receptor kinase 2 0.341272
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.332121
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.331756
ELF4 E74-like factor 4 (ets domain transcription factor) 0.330295
ATRN attractin 0.328469
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.325916
IL7R interleukin 7 receptor 0.324823
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.324458
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 0.324094
IL2RA interleukin 2 receptor, alpha 0.320817
AIRE autoimmune regulator 0.320817
B2M beta-2-microglobulin 0.318635
TLR2 toll-like receptor 2 0.317182
OAT ornithine aminotransferase 0.316456
PLCD1 phospholipase C, delta 1 0.315366
HLA-C major histocompatibility complex, class I, C 0.315003
ST7 suppression of tumorigenicity 7 0.309928
LCT lactase 0.295132
IGHV1-2 immunoglobulin heavy variable 1-2 0.292257
GRK4 G protein-coupled receptor kinase 4 0.286877
MYD88 myeloid differentiation primary response 88 0.286519
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.277227
GIF gastric intrinsic factor (vitamin B synthesis) 0.275801
LY9 lymphocyte antigen 9 0.274376
IGHV5-51 immunoglobulin heavy variable 5-51 0.272241
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.271174
TBX21 T-box 21 0.269398
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 0.267622
SBDS Shwachman-Bodian-Diamond syndrome 0.266203
FCRL4 Fc receptor-like 4 0.265849
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.265849
LTA lymphotoxin alpha 0.260538
CD80 CD80 molecule 0.257358
CD164 CD164 molecule, sialomucin 0.248905
CD22 CD22 molecule 0.242245
MST1R macrophage stimulating 1 receptor 0.241895
BCL6 B-cell CLL/lymphoma 6 0.240497
SLAMF6 SLAM family member 6 0.238403
IFNA1 interferon, alpha 1 0.238054
ALPPL2 alkaline phosphatase, placental-like 2 0.237706
ALPP alkaline phosphatase, placental 0.237357
ALPL alkaline phosphatase, liver/bone/kidney 0.23666
XCL1 chemokine (C motif) ligand 1 0.232142
TRAF3IP2 TRAF3 interacting protein 2 0.228679
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.227988
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.223853
PGK1 phosphoglycerate kinase 1 0.222136
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.220424
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.219057
PRIMA1 proline rich membrane anchor 1 0.218715
TLR3 toll-like receptor 3 0.218715
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.218374
KRTAP1-3 keratin associated protein 1-3 0.215314
KRTAP1-1 keratin associated protein 1-1 0.215314
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.211597
S1PR5 sphingosine-1-phosphate receptor 5 0.207912
USB1 U6 snRNA biogenesis 1 0.204923
C1ORF174 chromosome 1 open reading frame 174 0.204263
TLR8 toll-like receptor 8 0.203933
TOX thymocyte selection-associated high mobility group box 0.200656
LRRC4C leucine rich repeat containing 4C 0.199681
IL17RA interleukin 17 receptor A 0.19582
CD53 CD53 molecule 0.193915
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.185016
DAP death-associated protein 0.185016
GP6 glycoprotein VI (platelet) 0.182086
XPO1 exportin 1 0.17896
IL6 interleukin 6 0.178682
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.175411
GYPC glycophorin C (Gerbich blood group) 0.173314
EFNB3 ephrin-B3 0.172291
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.172291
C1R complement component 1, r subcomponent 0.171286
HLA-B major histocompatibility complex, class I, B 0.171036
MMP23B matrix metallopeptidase 23B 0.170299
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.167915
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.167915
LIG4 ligase IV, DNA, ATP-dependent 0.166544
CDC27 cell division cycle 27 0.164359
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.162505
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.162306
AHRR aryl-hydrocarbon receptor repressor 0.161523
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.160761
GLS2 glutaminase 2 (liver, mitochondrial) 0.140813
NELFCD negative elongation factor complex member C/D 0.140398
STAT5B signal transducer and activator of transcription 5B 0.140268
CCNG2 cyclin G2 0.139274
PCDH8 protocadherin 8 0.138241
EPHA2 EPH receptor A2 0.138127
SCRT1 scratch family zinc finger 1 0.137947
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.137887
FYB FYN binding protein 0.137437
PPP5C protein phosphatase 5, catalytic subunit 0.137098
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.136827
PPP6C protein phosphatase 6, catalytic subunit 0.136785
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.136531
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.136422
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.136312
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.136245
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.136109
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.136025
CHD7 chromodomain helicase DNA binding protein 7 0.135971
PROK2 prokineticin 2 0.134898
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.134638
PPP4C protein phosphatase 4, catalytic subunit 0.133978
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.13383
EFNB2 ephrin-B2 0.13377
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.132204
NUMBL numb homolog (Drosophila)-like 0.131456
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.131133
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.129129
EML4 echinoderm microtubule associated protein like 4 0.128893
CD63 CD63 molecule 0.126307
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.126248
FOXO1 forkhead box O1 0.125406
NRG1 neuregulin 1 0.123642
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.120753
PPT2 palmitoyl-protein thioesterase 2 0.117963
RGS1 regulator of G-protein signaling 1 0.117591
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.117497
PRKCD protein kinase C, delta 0.117185
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.116413
BHLHE40 basic helix-loop-helix family, member e40 0.116183
CXCR5 chemokine (C-X-C motif) receptor 5 0.115983
EGR1 early growth response 1 0.115983
TLR5 toll-like receptor 5 0.115849
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.115311
C5AR1 complement component 5a receptor 1 0.114622
SELL selectin L 0.111874
TP53 tumor protein p53 0.111797
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.111061
NLRP12 NLR family, pyrin domain containing 12 0.110662
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.110303
CARD9 caspase recruitment domain family, member 9 0.110022
CD248 CD248 molecule, endosialin 0.108994
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.108023
IL10 interleukin 10 0.107286
CD1D CD1d molecule 0.10618
OPRL1 opiate receptor-like 1 0.10463
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.104207
HLA-E major histocompatibility complex, class I, E 0.104067
RAD52 RAD52 homolog (S. cerevisiae) 0.103404
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.103116
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.103068
PNP purine nucleoside phosphorylase 0.10254
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.102295
CLU clusterin 0.102147