aged Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

156 genes co-occuring with the biological term aged in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPL alkaline phosphatase, liver/bone/kidney
ANKK1 ankyrin repeat and kinase domain containing 1
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
B2M beta-2-microglobulin
BACE1 beta-site APP-cleaving enzyme 1
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BIRC3 baculoviral IAP repeat containing 3
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA3 carbonic anhydrase III
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLU clusterin
COL1A1 collagen, type I, alpha 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRH corticotropin releasing hormone
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CRYBA1 crystallin, beta A1
CRYBB2 crystallin, beta B2
CSF3 colony stimulating factor 3 (granulocyte)
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
CTSS cathepsin S
CTSV cathepsin V
CYBB cytochrome b-245, beta polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DNM2 dynamin 2
DPP4 dipeptidyl-peptidase 4
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
ECE1 endothelin converting enzyme 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAS Fas cell surface death receptor
FGF7 fibroblast growth factor 7
FLT3 fms-related tyrosine kinase 3
FMR1 fragile X mental retardation 1
FTO fat mass and obesity associated
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GCKR glucokinase (hexokinase 4) regulator
GFAP glial fibrillary acidic protein
GHRH growth hormone releasing hormone
GHRL ghrelin/obestatin prepropeptide
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSTM1 glutathione S-transferase mu 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSPA4 heat shock 70kDa protein 4
IDO1 indoleamine 2,3-dioxygenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL21 interleukin 21
IL6 interleukin 6
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JAK2 Janus kinase 2
KL klotho
KLF4 Kruppel-like factor 4 (gut)
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
KRT10 keratin 10, type I
LBP lipopolysaccharide binding protein
LDLR low density lipoprotein receptor
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAPT microtubule-associated protein tau
MCM7 minichromosome maintenance complex component 7
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIP major intrinsic protein of lens fiber
MIR10A microRNA 10a
MIR93 microRNA 93
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSTN myostatin
MUC16 mucin 16, cell surface associated
NANOG Nanog homeobox
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
NUP107 nucleoporin 107kDa
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PARP1 poly (ADP-ribose) polymerase 1
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
PRNP prion protein
PSEN1 presenilin 1
PTAFR platelet-activating factor receptor
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
RBP4 retinol binding protein 4, plasma
S100B S100 calcium binding protein B
SCARB1 scavenger receptor class B, member 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD3 superoxide dismutase 3, extracellular
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAT4 signal transducer and activator of transcription 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBX21 T-box 21
TFRC transferrin receptor
TG thyroglobulin
THBD thrombomodulin
THBS1 thrombospondin 1
TNF tumor necrosis factor
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNS1 tensin 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TP53 tumor protein p53
TPH2 tryptophan hydroxylase 2
TPI1 triosephosphate isomerase 1
TREM2 triggering receptor expressed on myeloid cells 2
TTR transthyretin
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VWF von Willebrand factor
WWC1 WW and C2 domain containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase