aggressive periodontitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium. (Human Disease Ontology, DOID_1474)
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Genes

158 genes co-occuring with the disease aggressive periodontitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 1.71636
GLT6D1 glycosyltransferase 6 domain containing 1 1.51853
IL1B interleukin 1, beta 1.49394
FPR1 formyl peptide receptor 1 1.38123
IL1A interleukin 1, alpha 1.24037
MMP8 matrix metallopeptidase 8 1.22649
CTSC cathepsin C 1.17078
CKAP2L cytoskeleton associated protein 2-like 1.15794
HMGN2 high mobility group nucleosomal binding domain 2 1.15368
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.1507
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 1.14263
LTF lactotransferrin 1.05892
LYZL2 lysozyme-like 2 1.01427
MMP1 matrix metallopeptidase 1 0.978426
TLR4 toll-like receptor 4 0.953273
IL1RN interleukin 1 receptor antagonist 0.936214
DEFB4A defensin, beta 4A 0.880243
TNF tumor necrosis factor 0.876148
NLRP2 NLR family, pyrin domain containing 2 0.859362
C5AR1 complement component 5a receptor 1 0.849945
DGKD diacylglycerol kinase, delta 130kDa 0.848716
CD79A CD79a molecule, immunoglobulin-associated alpha 0.821667
PAQR7 progestin and adipoQ receptor family member VII 0.817155
KRT23 keratin 23, type I 0.816334
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.798692
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.779841
TLR2 toll-like receptor 2 0.760231
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.754527
IL6 interleukin 6 0.739488
CAMP cathelicidin antimicrobial peptide 0.73746
S100A8 S100 calcium binding protein A8 0.736649
SMR3B submaxillary gland androgen regulated protein 3B 0.734217
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.725716
TREM1 triggering receptor expressed on myeloid cells 1 0.713198
MMP26 matrix metallopeptidase 26 0.711989
IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) 0.710378
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.699517
SLAMF7 SLAM family member 7 0.681495
FCAR Fc fragment of IgA receptor 0.679898
PRB2 proline-rich protein BstNI subfamily 2 0.629635
FAM20A family with sequence similarity 20, member A 0.615921
ELANE elastase, neutrophil expressed 0.614747
CLU clusterin 0.608494
RPAP3 RNA polymerase II associated protein 3 0.607714
MPO myeloperoxidase 0.598351
BPIFA2 BPI fold containing family A, member 2 0.596402
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.596012
SELL selectin L 0.571884
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.565666
NLRP6 NLR family, pyrin domain containing 6 0.55945
LPO lactoperoxidase 0.554791
IL4 interleukin 4 0.554403
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.553627
MYOM2 myomesin 2 0.545093
DEFB1 defensin, beta 1 0.533861
OR5K1 olfactory receptor, family 5, subfamily K, member 1 0.529608
CXCL8 chemokine (C-X-C motif) ligand 8 0.529222
IL19 interleukin 19 0.508041
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.496557
CD4 CD4 molecule 0.490835
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.484364
STAC SH3 and cysteine rich domain 0.484364
GC group-specific component (vitamin D binding protein) 0.480945
CRP C-reactive protein, pentraxin-related 0.476393
IL17F interleukin 17F 0.467684
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 0.467684
IL10 interleukin 10 0.460883
CCL3 chemokine (C-C motif) ligand 3 0.457864
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.449194
BIN3 bridging integrator 3 0.442418
NOD1 nucleotide-binding oligomerization domain containing 1 0.430017
TIMP1 TIMP metallopeptidase inhibitor 1 0.425514
IL1R2 interleukin 1 receptor, type II 0.423265
MMP25 matrix metallopeptidase 25 0.420266
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.418394
MMP28 matrix metallopeptidase 28 0.418019
MMP2 matrix metallopeptidase 2 0.412779
MMP9 matrix metallopeptidase 9 0.410909
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.400826
DUOX1 dual oxidase 1 0.394491
AMY1B amylase, alpha 1B (salivary) 0.393746
AMY1C amylase, alpha 1C (salivary) 0.393746
AMY1A amylase, alpha 1A (salivary) 0.393746
IL12RB2 interleukin 12 receptor, beta 2 0.390025
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.388909
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.384451
DUOX2 dual oxidase 2 0.374438
AJAP1 adherens junctions associated protein 1 0.372587
CSN1S1 casein alpha s1 0.369258
LCN1 lipocalin 1 0.367779
FERMT1 fermitin family member 1 0.351923
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.351555
IL6ST interleukin 6 signal transducer 0.334315
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.312102
INSC inscuteable homolog (Drosophila) 0.309928
CCL2 chemokine (C-C motif) ligand 2 0.307033
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.305587
IL11 interleukin 11 0.294053
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.284013
GLB1 galactosidase, beta 1 0.281868
MCM8 minichromosome maintenance complex component 8 0.280082
IFNL1 interferon, lambda 1 0.279011
DLX5 distal-less homeobox 5 0.278297
HLA-A major histocompatibility complex, class I, A 0.273664
MMP7 matrix metallopeptidase 7 0.273308
GPI glucose-6-phosphate isomerase 0.267977
HLA-C major histocompatibility complex, class I, C 0.266913
GRAP2 GRB2-related adaptor protein 2 0.263368
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.261245
KLK11 kallikrein-related peptidase 11 0.25983
ADAM8 ADAM metallopeptidase domain 8 0.258417
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.257711
CTSD cathepsin D 0.23666
APOH apolipoprotein H (beta-2-glycoprotein I) 0.235964
GUSB glucuronidase, beta 0.233878
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.22937
MPZ myelin protein zero 0.227297
HIST3H2BB histone cluster 3, H2bb 0.22454
HIST2H2BF histone cluster 2, H2bf 0.223165
HIST1H2BA histone cluster 1, H2ba 0.220766
HIST1H2BH histone cluster 1, H2bh 0.220424
HIST1H2BD histone cluster 1, H2bd 0.220424
NLRP3 NLR family, pyrin domain containing 3 0.219057
CCL4 chemokine (C-C motif) ligand 4 0.211934
LPP LIM domain containing preferred translocation partner in lipoma 0.210589
LDHAL6A lactate dehydrogenase A-like 6A 0.209248
HIST1H2BC histone cluster 1, H2bc 0.207578
HIST1H2BF histone cluster 1, H2bf 0.207578
MMP12 matrix metallopeptidase 12 0.203275
PIGR polymeric immunoglobulin receptor 0.201962
ICAM1 intercellular adhesion molecule 1 0.196459
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.196139
AGPS alkylglycerone phosphate synthase 0.195183
COL4A1 collagen, type IV, alpha 1 0.194548
ALB albumin 0.193285
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.192657
IL12B interleukin 12B 0.190786
HAX1 HCLS1 associated protein X-1 0.190168
GADD45B growth arrest and DNA-damage-inducible, beta 0.188938
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.188326
BSG basigin (Ok blood group) 0.18621
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.183835
LYZ lysozyme 0.182375
BGLAP bone gamma-carboxyglutamate (gla) protein 0.181798
IL13 interleukin 13 0.181222
B2M beta-2-microglobulin 0.181222
CA6 carbonic anhydrase VI 0.180652
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.179239
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.178403
DYNLT1 dynein, light chain, Tctex-type 1 0.174617
ALPPL2 alkaline phosphatase, placental-like 2 0.174354
ALPP alkaline phosphatase, placental 0.174093
ALPL alkaline phosphatase, liver/bone/kidney 0.173571
WNT10A wingless-type MMTV integration site family, member 10A 0.172799
LMX1B LIM homeobox transcription factor 1, beta 0.170544
MMP3 matrix metallopeptidase 3 0.160387
CXCL10 chemokine (C-X-C motif) ligand 10 0.15948
FPR2 formyl peptide receptor 2 0.157765