aggressiveness Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

374 genes co-occuring with the biological term aggressiveness in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACHE acetylcholinesterase (Yt blood group)
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ADAM9 ADAM metallopeptidase domain 9
ADGRE5 adhesion G protein-coupled receptor E5
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOC1 apolipoprotein C-I
APOE apolipoprotein E
AR androgen receptor
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
ATR ATR serine/threonine kinase
BAK1 BCL2-antagonist/killer 1
BAMBI BMP and activin membrane-bound inhibitor
BCAR4 breast cancer anti-estrogen resistance 4 (non-protein coding)
BCL2 B-cell CLL/lymphoma 2
BCL2L2 BCL2-like 2
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
BTD biotinidase
CADM1 cell adhesion molecule 1
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CCND3 cyclin D3
CCNE1 cyclin E1
CCR3 chemokine (C-C motif) receptor 3
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD226 CD226 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC25C cell division cycle 25C
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CFLAR CASP8 and FADD-like apoptosis regulator
CHD8 chromodomain helicase DNA binding protein 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHKA choline kinase alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN4 claudin 4
CLDN7 claudin 7
CLIC1 chloride intracellular channel 1
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COX5A cytochrome c oxidase subunit Va
CRP C-reactive protein, pentraxin-related
CTTN cortactin
CUL3 cullin 3
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYR61 cysteine-rich, angiogenic inducer, 61
DAXX death-domain associated protein
DCX doublecortin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX4 distal-less homeobox 4
DPEP1 dipeptidase 1 (renal)
E2F1 E2F transcription factor 1
EBAG9 estrogen receptor binding site associated, antigen, 9
EGFR epidermal growth factor receptor
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5A2 eukaryotic translation initiation factor 5A2
ELAVL1 ELAV like RNA binding protein 1
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESRRA estrogen-related receptor alpha
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP3 fatty acid binding protein 3, muscle and heart
FASN fatty acid synthase
FER fer (fps/fes related) tyrosine kinase
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGFR4 fibroblast growth factor receptor 4
FGL2 fibrinogen-like 2
FHIT fragile histidine triad
FLNA filamin A, alpha
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOXA1 forkhead box A1
FOXD3 forkhead box D3
FOXM1 forkhead box M1
FOXQ1 forkhead box Q1
FRZB frizzled-related protein
FSCN1 fascin actin-bundling protein 1
FSCN2 fascin actin-bundling protein 2, retinal
FXYD5 FXYD domain containing ion transport regulator 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDF9 growth differentiation factor 9
GFRA1 GDNF family receptor alpha 1
GJA1 gap junction protein, alpha 1, 43kDa
GMNN geminin, DNA replication inhibitor
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPR55 G protein-coupled receptor 55
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HBEGF heparin-binding EGF-like growth factor
HDAC1 histone deacetylase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HK2 hexokinase 2
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HPCX hereditary prostate cancer, X-linked
HPSE heparanase
HPSE2 heparanase 2 (inactive)
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL17A interleukin 17A
IL18 interleukin 18
IL2RA interleukin 2 receptor, alpha
IL6 interleukin 6
INHBA inhibin, beta A
ITGA9 integrin, alpha 9
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAM3 junctional adhesion molecule 3
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLHDC8A kelch domain containing 8A
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
KLK13 kallikrein-related peptidase 13
KLK14 kallikrein-related peptidase 14
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KLRG2 killer cell lectin-like receptor subfamily G, member 2
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LEP leptin
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGMN legumain
LIN28A lin-28 homolog A (C. elegans)
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
MACC1 metastasis associated in colon cancer 1
MAOA monoamine oxidase A
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGLL monoglyceride lipase
MGMT O-6-methylguanine-DNA methyltransferase
MIR126 microRNA 126
MIR128-1 microRNA 128-1
MIR128-2 microRNA 128-2
MIR146A microRNA 146a
MIR150 microRNA 150
MIR182 microRNA 182
MIR183 microRNA 183
MIR200B microRNA 200b
MIR21 microRNA 21
MIR23B microRNA 23b
MIR25 microRNA 25
MIR26A1 microRNA 26a-1
MIR661 microRNA 661
MIR9-1 microRNA 9-1
MIR93 microRNA 93
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MLXIP MLX interacting protein
MME membrane metallo-endopeptidase
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MSR1 macrophage scavenger receptor 1
MTA1 metastasis associated 1
MTDH metadherin
MUC1 mucin 1, cell surface associated
MUTYH mutY homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO10 myosin X
NCAM1 neural cell adhesion molecule 1
NCOR2 nuclear receptor corepressor 2
ND1
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRG2 neuregulin 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUMB numb homolog (Drosophila)
NUP88 nucleoporin 88kDa
PABPN1 poly(A) binding protein, nuclear 1
PARD3 par-3 family cell polarity regulator
PCA3 prostate cancer associated 3 (non-protein coding)
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPN podoplanin
PEBP1 phosphatidylethanolamine binding protein 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PLAUR plasminogen activator, urokinase receptor
PLD2 phospholipase D2
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
POU3F2 POU class 3 homeobox 2
PREP prolyl endopeptidase
PRKD1 protein kinase D1
PROM1 prominin 1
PRUNE prune exopolyphosphatase
PRUNE2 prune homolog 2 (Drosophila)
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTOV1 prostate tumor overexpressed 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTTG1 pituitary tumor-transforming 1
PXN paxillin
RAB25 RAB25, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD51 RAD51 recombinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBM38 RNA binding motif protein 38
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RET ret proto-oncogene
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RSF1 remodeling and spacing factor 1
RUNX2 runt-related transcription factor 2
S100A11 S100 calcium binding protein A11
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SDC1 syndecan 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SGPL1 sphingosine-1-phosphate lyase 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A10 solute carrier family 39 (zinc transporter), member 10
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SNAI1 snail family zinc finger 1
SNX1 sorting nexin 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPARCL1 SPARC-like 1 (hevin)
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative)
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC1 stanniocalcin 1
STK39 serine threonine kinase 39
STMN1 stathmin 1
SUMO1 small ubiquitin-like modifier 1
TERT telomerase reverse transcriptase
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBD thrombomodulin
THBS1 thrombospondin 1
THOC1 THO complex 1
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMPRSS2 transmembrane protease, serine 2
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TSPO translocator protein (18kDa)
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT8 UDP glycosyltransferase 8
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
WISP2 WNT1 inducible signaling pathway protein 2
WISP3 WNT1 inducible signaling pathway protein 3
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
WWOX WW domain containing oxidoreductase
XDH xanthine dehydrogenase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YBX1 Y box binding protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZEB2 zinc finger E-box binding homeobox 2