aging Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700). (Gene Ontology, GO_0007568)
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Genes

26 genes associated with the disease aging in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKAP10 A kinase (PRKA) anchor protein 10
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOE apolipoprotein E
AR androgen receptor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
HMOX1 heme oxygenase 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KL klotho
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LRP1B low density lipoprotein receptor-related protein 1B
MEFV Mediterranean fever
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
PPARA peroxisome proliferator-activated receptor alpha
SHBG sex hormone-binding globulin
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)