aging Gene Set

Dataset GO Biological Process Annotations 2015
Category structural or functional annotations
Type biological process
Description A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700). (Gene Ontology, GO_0007568)
External Link http://amigo.geneontology.org/amigo/term/GO:0007568
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Genes

204 genes participating in the aging biological process from the curated GO Biological Process Annotations 2015 dataset.

Symbol Name
ADA adenosine deaminase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADM adrenomedullin
ADRA1A adrenoceptor alpha 1A
ADRB1 adrenoceptor beta 1
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ALOX12 arachidonate 12-lipoxygenase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMH anti-Mullerian hormone
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOD apolipoprotein D
APOE apolipoprotein E
AQP2 aquaporin 2 (collecting duct)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATR ATR serine/threonine kinase
AURKB aurora kinase B
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BRCA2 breast cancer 2, early onset
C2ORF40 chromosome 2 open reading frame 40
CACYBP calcyclin binding protein
CALCA calcitonin-related polypeptide alpha
CALR calreticulin
CANX calnexin
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CD86 CD86 molecule
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CISD2 CDGSH iron sulfur domain 2
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNR1 cannabinoid receptor 1 (brain)
COL3A1 collagen, type III, alpha 1
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CTC1 CTS telomere maintenance complex component 1
CTGF connective tissue growth factor
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSC cathepsin C
CTSV cathepsin V
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
ENG endoglin
ENO3 enolase 3 (beta, muscle)
EPO erythropoietin
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
GJB6 gap junction protein, beta 6, 30kDa
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GRB2 growth factor receptor-bound protein 2
GSN gelsolin
GSS glutathione synthetase
HELT helt bHLH transcription factor
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTT huntingtin
HYAL2 hyaluronoglucosaminidase 2
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL10 interleukin 10
IL15 interleukin 15
IL6 interleukin 6
ILK integrin-linked kinase
IRAK1 interleukin-1 receptor-associated kinase 1
IREB2 iron-responsive element binding protein 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KL klotho
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT25 keratin 25, type I
KRT33B keratin 33B, type I
KRT83 keratin 83, type II
KRTAP4-3 keratin associated protein 4-3
KRTAP4-5 keratin associated protein 4-5
KRTAP4-8 keratin associated protein 4-8
KRTAP4-9 keratin associated protein 4-9
LCK LCK proto-oncogene, Src family tyrosine kinase
LIMS1 LIM and senescent cell antigen-like domains 1
LITAF lipopolysaccharide-induced TNF factor
LOC100996750 keratin-associated protein 4-7
LONP1 lon peptidase 1, mitochondrial
LOXL2 lysyl oxidase-like 2
LRP1 low density lipoprotein receptor-related protein 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MBP myelin basic protein
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MME membrane metallo-endopeptidase
MNT MAX network transcriptional repressor
MORC3 MORC family CW-type zinc finger 3
MPO myeloperoxidase
NCF2 neutrophil cytosolic factor 2
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
OGG1 8-oxoguanine DNA glycosylase
OPA1 optic atrophy 1 (autosomal dominant)
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAX2 paired box 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4D phosphodiesterase 4D, cAMP-specific
PDX1 pancreatic and duodenal homeobox 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PML promyelocytic leukemia
POLG polymerase (DNA directed), gamma
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCD protein kinase C, delta
PTEN phosphatase and tensin homolog
PTH1R parathyroid hormone 1 receptor
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
ROMO1 reactive oxygen species modulator 1
RPN2 ribophorin II
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCAP SREBF chaperone
SEC63 SEC63 homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIN3A SIN3 transcription regulator family member A
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMC5 structural maintenance of chromosomes 5
SMC6 structural maintenance of chromosomes 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS2 suppressor of cytokine signaling 2
SOD1 superoxide dismutase 1, soluble
SPEF2 sperm flagellar 2
SREBF1 sterol regulatory element binding transcription factor 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRR serine racemase
TACR3 tachykinin receptor 3
TBX2 T-box 2
TBX3 T-box 3
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TH tyrosine hydroxylase
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TP63 tumor protein p63
TPRA1 transmembrane protein, adipocyte asscociated 1
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TSPO translocator protein (18kDa)
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
ULK3 unc-51 like kinase 3
VCAM1 vascular cell adhesion molecule 1
WNT16 wingless-type MMTV integration site family, member 16
WRN Werner syndrome, RecQ helicase-like
ZMIZ1 zinc finger, MIZ-type containing 1