aging Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700). (Gene Ontology, GO_0007568)
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Genes

344 genes co-occuring with the biological term aging in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ACTN3 actinin, alpha 3 (gene/pseudogene)
ADAM10 ADAM metallopeptidase domain 10
ADAM15 ADAM metallopeptidase domain 15
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
ADRBK2 adrenergic, beta, receptor kinase 2
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMY1A amylase, alpha 1A (salivary)
ANXA5 annexin A5
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APLN apelin
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARSA arylsulfatase A
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATR ATR serine/threonine kinase
BACE1 beta-site APP-cleaving enzyme 1
BANF1 barrier to autointegration factor 1
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCYRN1 brain cytoplasmic RNA 1
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BICD1 bicaudal D homolog 1 (Drosophila)
BIN1 bridging integrator 1
BLVRA biliverdin reductase A
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BSG basigin (Ok blood group)
CA3 carbonic anhydrase III
CANX calnexin
CAT catalase
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD200R1 CD200 receptor 1
CD28 CD28 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CERS1 ceramide synthase 1
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CHAT choline O-acetyltransferase
CHRM2 cholinergic receptor, muscarinic 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
CNTNAP4 contactin associated protein-like 4
COMT catechol-O-methyltransferase
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
COX1
CP ceruloplasmin (ferroxidase)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRP C-reactive protein, pentraxin-related
CRYAA crystallin, alpha A
CSPG4 chondroitin sulfate proteoglycan 4
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5R3 cytochrome b5 reductase 3
CYBA cytochrome b-245, alpha polypeptide
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DIAPH2 diaphanous-related formin 2
DICER1 dicer 1, ribonuclease type III
DIO2 deiodinase, iodothyronine, type II
DISC1 disrupted in schizophrenia 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMD dystrophin
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EDN1 endothelin 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGR1 early growth response 1
ELK1 ELK1, member of ETS oncogene family
ELN elastin
ENG endoglin
ENHO energy homeostasis associated
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF20 fibroblast growth factor 20
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FTO fat mass and obesity associated
FXN frataxin
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GAP43 growth associated protein 43
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GCG glucagon
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GLO1 glyoxalase I
GLUD1 glutamate dehydrogenase 1
GNAS GNAS complex locus
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPX1 glutathione peroxidase 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK5 G protein-coupled receptor kinase 5
GRK6 G protein-coupled receptor kinase 6
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H2AFX H2A histone family, member X
HAS2 hyaluronan synthase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HP haptoglobin
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
IL1B interleukin 1, beta
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL33R interleukin 33 receptor
IL6 interleukin 6
IL7R interleukin 7 receptor
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
IRF1 interferon regulatory factor 1
ISG15 ISG15 ubiquitin-like modifier
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JDP2 Jun dimerization protein 2
KAT6B K(lysine) acetyltransferase 6B
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KIF2C kinesin family member 2C
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KL klotho
KRT5 keratin 5, type II
LAMP2 lysosomal-associated membrane protein 2
LEMD3 LEM domain containing 3
LEP leptin
LIN28B lin-28 homolog B (C. elegans)
LMNA lamin A/C
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LPL lipoprotein lipase
LRP1B low density lipoprotein receptor-related protein 1B
LRRK2 leucine-rich repeat kinase 2
LRRTM3 leucine rich repeat transmembrane neuronal 3
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MFGE8 milk fat globule-EGF factor 8 protein
MIR144 microRNA 144
MIR146A microRNA 146a
MIR21 microRNA 21
MIR23A microRNA 23a
MIR30A microRNA 30a
MKRN1 makorin ring finger protein 1
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP20 matrix metallopeptidase 20
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MORF4L1 mortality factor 4 like 1
MPL MPL proto-oncogene, thrombopoietin receptor
MSRA methionine sulfoxide reductase A
MSRB2 methionine sulfoxide reductase B2
MSRB3 methionine sulfoxide reductase B3
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NAMPT nicotinamide phosphoribosyltransferase
NANOG Nanog homeobox
NCAM1 neural cell adhesion molecule 1
NCF1 neutrophil cytosolic factor 1
ND1
NDN necdin, melanoma antigen (MAGE) family member
NES nestin
NEU1 sialidase 1 (lysosomal sialidase)
NEU3 sialidase 3 (membrane sialidase)
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOX1 NADPH oxidase 1
NOX4 NADPH oxidase 4
NPC1 Niemann-Pick disease, type C1
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPY neuropeptide Y
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRG1 neuregulin 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPRD1 opioid receptor, delta 1
OTX2 orthodenticle homeobox 2
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PABPN1 poly(A) binding protein, nuclear 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PDE5A phosphodiesterase 5A, cGMP-specific
PER2 period circadian clock 2
PI3 peptidase inhibitor 3, skin-derived
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PINK1 PTEN induced putative kinase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PON1 paraoxonase 1
POSTN periostin, osteoblast specific factor
POU2F1 POU class 2 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRNP prion protein
PSEN1 presenilin 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCR1 pyrroline-5-carboxylate reductase 1
PYY peptide YY
RBP4 retinol binding protein 4, plasma
RECQL4 RecQ protein-like 4
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RGN regucalcin
RGS4 regulator of G-protein signaling 4
RHD Rh blood group, D antigen
RPS3 ribosomal protein S3
RUNX1 runt-related transcription factor 1
S100B S100 calcium binding protein B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT1 sirtuin 1
SIRT5 sirtuin 5
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SORT1 sortilin 1
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SRFBP1 serum response factor binding protein 1
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STXBP5L syntaxin binding protein 5-like
TAS2R16 taste receptor, type 2, member 16
TBC1D4 TBC1 domain family, member 4
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TH tyrosine hydroxylase
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TPH1 tryptophan hydroxylase 1
TRA T cell receptor alpha locus
TREM1 triggering receptor expressed on myeloid cells 1
TRG T cell receptor gamma locus
TST thiosulfate sulfurtransferase (rhodanese)
TTR transthyretin
TYR tyrosinase
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WRN Werner syndrome, RecQ helicase-like