agt Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description angiotensinogen (serpin peptidase inhibitor, clade A, member 8)|The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 183)
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Genes

36 genes co-occuring with the biological term agt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADD1 adducin 1 (alpha)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CTSD cathepsin D
CXCL12 chemokine (C-X-C motif) ligand 12
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GPX1 glutathione peroxidase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSPA8 heat shock 70kDa protein 8
IL6 interleukin 6
JUND jun D proto-oncogene
MGMT O-6-methylguanine-DNA methyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR1 natriuretic peptide receptor 1
OLFM4 olfactomedin 4
OPRD1 opioid receptor, delta 1
OTSC2 otosclerosis 2
OTSC5 otosclerosis 5
PDYN prodynorphin
RELN reelin
REN renin
SATB1 SATB homeobox 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TGFB1 transforming growth factor, beta 1
THBS2 thrombospondin 2
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
USF1 upstream transcription factor 1