ahr_19454665_epidermal_langerhans_cell_lof_mouse_gpl339_gds3575 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS3575
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Genes

254 genes differentially expressed following the ahr_19454665_epidermal_langerhans_cell_lof_mouse_gpl339_gds3575 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
RAB5B RAB5B, member RAS oncogene family 0.210254
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.209997
RPS6KL1 ribosomal protein S6 kinase-like 1 0.20883
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.208703
CTRL chymotrypsin-like 0.206916
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.205521
CHD1 chromodomain helicase DNA binding protein 1 0.202946
ZC3H12C zinc finger CCCH-type containing 12C 0.202917
UNC93B1 unc-93 homolog B1 (C. elegans) 0.200083
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.194843
MVD mevalonate (diphospho) decarboxylase 0.192532
TGM2 transglutaminase 2 0.187549
API5 apoptosis inhibitor 5 0.180841
RAD23A RAD23 homolog A (S. cerevisiae) 0.179108
TOM1L2 target of myb1-like 2 (chicken) 0.178465
HDGFRP2 hepatoma-derived growth factor-related protein 2 0.174694
RNF103 ring finger protein 103 0.172699
ARFIP2 ADP-ribosylation factor interacting protein 2 0.171815
FNDC4 fibronectin type III domain containing 4 0.166221
PYHIN1 pyrin and HIN domain family, member 1 0.165422
AMBP alpha-1-microglobulin/bikunin precursor 0.164389
SYT5 synaptotagmin V 0.163967
RBM4B RNA binding motif protein 4B 0.161684
CNR1 cannabinoid receptor 1 (brain) 0.152553
BTG2 BTG family, member 2 0.151499
EHD3 EH-domain containing 3 0.149308
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 0.147528
TSPAN6 tetraspanin 6 0.146742
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 0.140527
ISG15 ISG15 ubiquitin-like modifier 0.139348
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.138197
SOX10 SRY (sex determining region Y)-box 10 0.136323
THRAP3 thyroid hormone receptor associated protein 3 0.135663
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 0.13513
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.133916
IGFBP7 insulin-like growth factor binding protein 7 0.132283
SPC25 SPC25, NDC80 kinetochore complex component 0.128095
CLDN14 claudin 14 0.127564
CORO1C coronin, actin binding protein, 1C 0.126467
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 0.124046
MUCL1 mucin-like 1 0.123626
MAGEB3 melanoma antigen family B3 0.123454
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.12336
CYBRD1 cytochrome b reductase 1 0.121488
KIF1A kinesin family member 1A 0.113168
HLF hepatic leukemia factor 0.112322
HP1BP3 heterochromatin protein 1, binding protein 3 0.112261
TM7SF3 transmembrane 7 superfamily member 3 0.111814
EPN2 epsin 2 0.109847
STXBP6 syntaxin binding protein 6 (amisyn) 0.108009
ARL14EP ADP-ribosylation factor-like 14 effector protein 0.10778
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.105688
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.105216
CCL1 chemokine (C-C motif) ligand 1 0.104577
CD300C CD300c molecule 0.101815
STAMBPL1 STAM binding protein-like 1 0.095599
CHIC1 cysteine-rich hydrophobic domain 1 0.095106
DNAJB3 DnaJ (Hsp40) homolog, subfamily B, member 3 0.092899
ACP2 acid phosphatase 2, lysosomal 0.092497
BST1 bone marrow stromal cell antigen 1 0.085756
NKX2-3 NK2 homeobox 3 0.083711
PLK1 polo-like kinase 1 0.083303
STYX serine/threonine/tyrosine interacting protein 0.07528
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.072766
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.066315
N4BP3 NEDD4 binding protein 3 0.064749
FBLN7 fibulin 7 0.063921
ZFP57 ZFP57 zinc finger protein 0.056035
STARD4 StAR-related lipid transfer (START) domain containing 4 0.04931
RAB20 RAB20, member RAS oncogene family 0.049164
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.042653
KRAS Kirsten rat sarcoma viral oncogene homolog 0.041663
ALX3 ALX homeobox 3 0.040762
KLF6 Kruppel-like factor 6 0.040087
ENDOU endonuclease, polyU-specific 0.039022
KITLG KIT ligand 0.03311
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.032974
PIBF1 progesterone immunomodulatory binding factor 1 0.031344
TRIM35 tripartite motif containing 35 0.029535
PITPNB phosphatidylinositol transfer protein, beta 0.027553
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.018586
FUS FUS RNA binding protein 0.01851
PXN paxillin 0.018025
LIMS2 LIM and senescent cell antigen-like domains 2 0.017617
MTMR2 myotubularin related protein 2 0.017566
B2M beta-2-microglobulin 0.017439
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.016727
CUL2 cullin 2 0.016397
C19ORF47 chromosome 19 open reading frame 47 0.016271
TMEM38B transmembrane protein 38B 0.015915
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.011415
MAP3K6 mitogen-activated protein kinase kinase kinase 6 0.007787
LASP1 LIM and SH3 protein 1 0.007641
RFTN2 raftlin family member 2 0.004228
CD83 CD83 molecule 0.002285
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 6.2E-5

decreased expression

Symbol Name Standardized Value
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -1.16207
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -1.15749
POU2F1 POU class 2 homeobox 1 -1.15611
GLDC glycine dehydrogenase (decarboxylating) -1.15564
NR4A2 nuclear receptor subfamily 4, group A, member 2 -1.15144
ARPP21 cAMP-regulated phosphoprotein, 21kDa -1.13686
DEPTOR DEP domain containing MTOR-interacting protein -1.13572
GUCY1B3 guanylate cyclase 1, soluble, beta 3 -1.1355
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) -1.13286
TCTEX1D4 Tctex1 domain containing 4 -1.13032
CDH13 cadherin 13 -1.1272
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -1.11481
GJA4 gap junction protein, alpha 4, 37kDa -1.11274
DUSP10 dual specificity phosphatase 10 -1.11208
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) -1.09112
HNF4G hepatocyte nuclear factor 4, gamma -1.0907
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -1.08721
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -1.06784
GRK6 G protein-coupled receptor kinase 6 -1.06353
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -1.04734
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -1.03862
GNRHR gonadotropin-releasing hormone receptor -1.03519
PRNP prion protein -1.03354
TAC1 tachykinin, precursor 1 -1.02159
DOK3 docking protein 3 -1.01714
FGFR1 fibroblast growth factor receptor 1 -1.00078
IER3 immediate early response 3 -0.979613
GAL3ST1 galactose-3-O-sulfotransferase 1 -0.97074
ENOPH1 enolase-phosphatase 1 -0.967831
ACKR3 atypical chemokine receptor 3 -0.961264
NEUROD1 neuronal differentiation 1 -0.95407
JMJD7 jumonji domain containing 7 -0.936507
RTN4R reticulon 4 receptor -0.935965
SSBP2 single-stranded DNA binding protein 2 -0.928267
AHRR aryl-hydrocarbon receptor repressor -0.920909
GPR12 G protein-coupled receptor 12 -0.920262
FOXM1 forkhead box M1 -0.913496
PRSS35 protease, serine, 35 -0.908665
PTH1R parathyroid hormone 1 receptor -0.88753
LPP LIM domain containing preferred translocation partner in lipoma -0.872462
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -0.863468
CDRT4 CMT1A duplicated region transcript 4 -0.850928
ARPC5L actin related protein 2/3 complex, subunit 5-like -0.843726
MRAS muscle RAS oncogene homolog -0.841807
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.832072
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.810852
FNTA farnesyltransferase, CAAX box, alpha -0.805751
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.797271
ZFP36L2 ZFP36 ring finger protein-like 2 -0.79014
PRKCE protein kinase C, epsilon -0.789859
TPGS1 tubulin polyglutamylase complex subunit 1 -0.781411
PBX1 pre-B-cell leukemia homeobox 1 -0.779436
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -0.760392
CHMP4C charged multivesicular body protein 4C -0.755968
CCDC47 coiled-coil domain containing 47 -0.742192
GMCL1 germ cell-less, spermatogenesis associated 1 -0.737693
SIRT2 sirtuin 2 -0.73594
ACTL7A actin-like 7A -0.725163
RAB34 RAB34, member RAS oncogene family -0.717158
FECH ferrochelatase -0.716282
PCBP4 poly(rC) binding protein 4 -0.699346
ZBTB16 zinc finger and BTB domain containing 16 -0.69927
NUP133 nucleoporin 133kDa -0.677411
GTF2I general transcription factor IIi -0.656838
IGF2 insulin-like growth factor 2 -0.649697
NSUN4 NOP2/Sun domain family, member 4 -0.6405
RIOK3 RIO kinase 3 -0.632857
PARK7 parkinson protein 7 -0.63189
ARRB1 arrestin, beta 1 -0.626406
RAB6A RAB6A, member RAS oncogene family -0.606712
IDO1 indoleamine 2,3-dioxygenase 1 -0.596109
MFF mitochondrial fission factor -0.5947
RAB2A RAB2A, member RAS oncogene family -0.592682
NAP1L3 nucleosome assembly protein 1-like 3 -0.585941
RWDD3 RWD domain containing 3 -0.57423
CAPN6 calpain 6 -0.56998
MIB2 mindbomb E3 ubiquitin protein ligase 2 -0.565919
DUSP16 dual specificity phosphatase 16 -0.563929
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.560719
WDR61 WD repeat domain 61 -0.556365
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.542588
CASP3 caspase 3, apoptosis-related cysteine peptidase -0.541479
SMIM14 small integral membrane protein 14 -0.537313
C4B complement component 4B (Chido blood group) -0.536082
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -0.526834
HEPH hephaestin -0.517466
PRKD2 protein kinase D2 -0.514035
SEPT4 septin 4 -0.514035
UBA3 ubiquitin-like modifier activating enzyme 3 -0.507493
CRBN cereblon -0.506006
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -0.501495
IL1F10 interleukin 1 family, member 10 (theta) -0.499762
SLC17A2 solute carrier family 17, member 2 -0.49485
SIM1 single-minded family bHLH transcription factor 1 -0.494692
REEP1 receptor accessory protein 1 -0.489962
ZNF14 zinc finger protein 14 -0.489502
SCNM1 sodium channel modifier 1 -0.488508
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.479676
HPD 4-hydroxyphenylpyruvate dioxygenase -0.478127
RTBDN retbindin -0.476363
PKP2 plakophilin 2 -0.472547
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 -0.470806
KIF2A kinesin heavy chain member 2A -0.469534
RPL35 ribosomal protein L35 -0.462982
EMC4 ER membrane protein complex subunit 4 -0.461291
NADK NAD kinase -0.456486
MRPL16 mitochondrial ribosomal protein L16 -0.452898
GPX7 glutathione peroxidase 7 -0.451645
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.449523
NARF nuclear prelamin A recognition factor -0.448779
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.446318
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 -0.441991
DFNA5 deafness, autosomal dominant 5 -0.441247
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.439273
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.434341
PPA2 pyrophosphatase (inorganic) 2 -0.433536
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) -0.43171
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.427736
UBE2B ubiquitin-conjugating enzyme E2B -0.426915
SIX4 SIX homeobox 4 -0.425149
FAM129B family with sequence similarity 129, member B -0.424578
FBXW2 F-box and WD repeat domain containing 2 -0.421509
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -0.066359
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.065
KLK1 kallikrein 1 -0.064627
OSBPL1A oxysterol binding protein-like 1A -0.064503
TMEM134 transmembrane protein 134 -0.063176
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.062471
GJB5 gap junction protein, beta 5, 31.1kDa -0.061819
MLPH melanophilin -0.060955
NELFE negative elongation factor complex member E -0.060239
CCNB1 cyclin B1 -0.056886
ZNF106 zinc finger protein 106 -0.0549
AURKA aurora kinase A -0.052339
GCAT glycine C-acetyltransferase -0.043439
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -0.042863
PRKCH protein kinase C, eta -0.042658
TENM4 teneurin transmembrane protein 4 -0.040121
PPP1R32 protein phosphatase 1, regulatory subunit 32 -0.036977
RNF115 ring finger protein 115 -0.033622
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -0.032805
RCN3 reticulocalbin 3, EF-hand calcium binding domain -0.02685
PKP3 plakophilin 3 -0.025992
ADK adenosine kinase -0.023222
APOE apolipoprotein E -0.022103
ASL argininosuccinate lyase -0.021657
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.021167
BLZF1 basic leucine zipper nuclear factor 1 -0.01991
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.018966
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) -0.017206
TOB2 transducer of ERBB2, 2 -0.013623
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.012185
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.010195
SLC19A1 solute carrier family 19 (folate transporter), member 1 -0.008383
DXO decapping exoribonuclease -0.007623
SYT1 synaptotagmin I -0.002376
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -0.001448
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -9.38E-4