| Dataset | GeneRIF Biological Term Annotations |
| Category | structural or functional annotations |
| Type | biological term |
| Description | A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.|An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.|A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. -- 2004|Acquired immunodeficiency syndrome is a HIV infection consisting of a disease of the human immune system that is characterized cytologically especially by a reduction in the numbers of CD4-bearing helper T cells to 20 percent or less of normal thereby rendering the subject highly vulnerable to life-threatening conditions (as Pneumocystis carinii pneumonia) and to some that become life threatening (as Kaposi's sarcoma) and that is caused by infection with HIV commonly transmitted in infected blood especially during illicit intravenous drug use and in bodily secretions (as semen) during sexual intercourse.|An HIV infectious disease that is a characterized cytologically by a reduction in the numbers of CD4-bearing helper T cells to 20 percent or less of normal thereby rendering the subject highly vulnerable to life-threatening conditions (as Pneumocystis carinii pneumonia) and to some that become life threatening (as Kaposi's sarcoma) and that is caused by infection with HIV commonly transmitted in infected blood especially during illicit intravenous drug use and in bodily secretions (as semen) during sexual intercourse.|A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.|A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per µL of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_agent Human immunodeficiency virus 1 or has_agent Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. (Experimental Factor Ontology, EFO_0000765) |
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97 genes co-occuring with the biological term aids in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
| Symbol | Name |
|---|---|
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) |
| ACSM4 | acyl-CoA synthetase medium-chain family member 4 |
| AICDA | activation-induced cytidine deaminase |
| AIPL1 | aryl hydrocarbon receptor interacting protein-like 1 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G |
| ARHGAP44 | Rho GTPase activating protein 44 |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| CCL19 | chemokine (C-C motif) ligand 19 |
| CCL3L1 | chemokine (C-C motif) ligand 3-like 1 |
| CCL4 | chemokine (C-C motif) ligand 4 |
| CCL5 | chemokine (C-C motif) ligand 5 |
| CCR2 | chemokine (C-C motif) receptor 2 |
| CCR5 | chemokine (C-C motif) receptor 5 (gene/pseudogene) |
| CD209 | CD209 molecule |
| CD274 | CD274 molecule |
| CD4 | CD4 molecule |
| CD47 | CD47 molecule |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CDK9 | cyclin-dependent kinase 9 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) |
| CRP | C-reactive protein, pentraxin-related |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa |
| CUL5 | cullin 5 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 |
| CXCR6 | chemokine (C-X-C motif) receptor 6 |
| CYBA | cytochrome b-245, alpha polypeptide |
| CYP3A4 | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| DAPK1 | death-associated protein kinase 1 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa |
| ERCC2 | excision repair cross-complementation group 2 |
| FAS | Fas cell surface death receptor |
| FASLG | Fas ligand (TNF superfamily, member 6) |
| FN1 | fibronectin 1 |
| G6PD | glucose-6-phosphate dehydrogenase |
| GLRA1 | glycine receptor, alpha 1 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide |
| GOLM1 | golgi membrane protein 1 |
| GSK3B | glycogen synthase kinase 3 beta |
| HAVCR1 | hepatitis A virus cellular receptor 1 |
| HLA-B | major histocompatibility complex, class I, B |
| HLA-C | major histocompatibility complex, class I, C |
| HLA-G | major histocompatibility complex, class I, G |
| IFNG | interferon, gamma |
| IGF1 | insulin-like growth factor 1 (somatomedin C) |
| IL10 | interleukin 10 |
| IL10RA | interleukin 10 receptor, alpha |
| IL18 | interleukin 18 |
| IL2 | interleukin 2 |
| IL21 | interleukin 21 |
| IL4 | interleukin 4 |
| IL6 | interleukin 6 |
| IL7 | interleukin 7 |
| IL7R | interleukin 7 receptor |
| LEP | leptin |
| LRP1 | low density lipoprotein receptor-related protein 1 |
| MAPK14 | mitogen-activated protein kinase 14 |
| MAPK8 | mitogen-activated protein kinase 8 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble |
| MEF2C | myocyte enhancer factor 2C |
| MIR494 | microRNA 494 |
| MTOR | mechanistic target of rapamycin (serine/threonine kinase) |
| NKX2-2 | NK2 homeobox 2 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NUP98 | nucleoporin 98kDa |
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 |
| PARD3B | par-3 family cell polarity regulator beta |
| PCNA | proliferating cell nuclear antigen |
| PLAUR | plasminogen activator, urokinase receptor |
| PLG | plasminogen |
| PROX1 | prospero homeobox 1 |
| PTN | pleiotrophin |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
| RP2 | retinitis pigmentosa 2 (X-linked recessive) |
| RPRD1B | regulation of nuclear pre-mRNA domain containing 1B |
| SFTPD | surfactant protein D |
| SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
| SLCO1B1 | solute carrier organic anion transporter family, member 1B1 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SNAI2 | snail family zinc finger 2 |
| SRSF6 | serine/arginine-rich splicing factor 6 |
| THBS1 | thrombospondin 1 |
| THY1 | Thy-1 cell surface antigen |
| TLR7 | toll-like receptor 7 |
| TLR9 | toll-like receptor 9 |
| TNFRSF13C | tumor necrosis factor receptor superfamily, member 13C |
| TNPO3 | transportin 3 |
| TP53 | tumor protein p53 |
| TRG | T cell receptor gamma locus |
| TSG101 | tumor susceptibility 101 |
| UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor |
| YBX1 | Y box binding protein 1 |
