aire Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	autoimmune regulator\|This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 326)
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Genes

12 genes co-occuring with the biological term aire in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
AIRE	autoimmune regulator
DAXX	death-domain associated protein
DEAF1	DEAF1 transcription factor
IFNW1	interferon, omega 1
INS	insulin
KRT17	keratin 17, type I
PRKDC	protein kinase, DNA-activated, catalytic polypeptide
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11
TP63	tumor protein p63
UBAC1	UBA domain containing 1