akt1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description v-akt murine thymoma viral oncogene homolog 1|The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 207)
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Genes

130 genes co-occuring with the biological term akt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTN4 actinin, alpha 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AKTIP AKT interacting protein
AR androgen receptor
ARRB1 arrestin, beta 1
AURKA aurora kinase A
BCL10 B-cell CLL/lymphoma 10
BCR breakpoint cluster region
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTN1A1 butyrophilin, subfamily 1, member A1
C11ORF30 chromosome 11 open reading frame 30
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CFLAR CASP8 and FADD-like apoptosis regulator
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRTC2 CREB regulated transcription coactivator 2
CTBP1 C-terminal binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAM110C family with sequence similarity 110, member C
FAM32A family with sequence similarity 32, member A
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FOXO1 forkhead box O1
HDAC3 histone deacetylase 3
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HRAS Harvey rat sarcoma viral oncogene homolog
INS insulin
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IWS1 IWS1 homolog (S. cerevisiae)
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KLF4 Kruppel-like factor 4 (gut)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LIF leukemia inhibitory factor
LRRK2 leucine-rich repeat kinase 2
LRRTM1 leucine rich repeat transmembrane neuronal 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MIR133B microRNA 133b
MIR149 microRNA 149
MIR302A microRNA 302a
MIR367 microRNA 367
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOG noggin
NOS3 nitric oxide synthase 3 (endothelial cell)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PALLD palladin, cytoskeletal associated protein
PARD6A par-6 family cell polarity regulator alpha
PCBP1 poly(rC) binding protein 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PGR progesterone receptor
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RET ret proto-oncogene
RHOC ras homolog family member C
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RTN4 reticulon 4
RUNX3 runt-related transcription factor 3
SGK1 serum/glucocorticoid regulated kinase 1
SIRT6 sirtuin 6
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMO smoothened, frizzled class receptor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
SYAP1 synapse associated protein 1
TAL1 T-cell acute lymphocytic leukemia 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TKT transketolase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
UVRAG UV radiation resistance associated
VEGFA vascular endothelial growth factor A
VIM vimentin
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
XPC xeroderma pigmentosum, complementation group C