akt1 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description v-akt murine thymoma viral oncogene homolog 1|The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 207)
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Genes

69 proteins co-occuring with the biological term akt1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BCL10 B-cell CLL/lymphoma 10
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHEK1 checkpoint kinase 1
CHUK conserved helix-loop-helix ubiquitous kinase
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EP300 E1A binding protein p300
FOXO1 forkhead box O1
FOXO4 forkhead box O4
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HMOX1 heme oxygenase 1
HTRA2 HtrA serine peptidase 2
ILK integrin-linked kinase
IRS1 insulin receptor substrate 1
KRT18 keratin 18, type I
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK9 mitogen-activated protein kinase 9
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS3 nitric oxide synthase 3 (endothelial cell)
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
PALLD palladin, cytoskeletal associated protein
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
RB1 retinoblastoma 1
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK38 serine/threonine kinase 38
STXBP4 syntaxin binding protein 4
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D4 TBC1 domain family, member 4
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase