alcohol dependence Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)|Disorders related to or resulting from abuse or mis-use of alcohol. (Experimental Factor Ontology, EFO_0003829)
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Genes

320 genes co-occuring with the disease alcohol dependence in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.56721
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.40054
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.24577
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2.13921
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.06171
DRD2 dopamine receptor D2 2.02658
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 1.99826
OPRM1 opioid receptor, mu 1 1.88805
GGT1 gamma-glutamyltransferase 1 1.83228
ANKK1 ankyrin repeat and kinase domain containing 1 1.82685
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.68181
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.6534
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.64891
ADH6 alcohol dehydrogenase 6 (class V) 1.63052
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 1.62247
CHRM2 cholinergic receptor, muscarinic 2 1.54054
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.47198
DRD4 dopamine receptor D4 1.45133
NKAIN1 Na+/K+ transporting ATPase interacting 1 1.44035
OPRD1 opioid receptor, delta 1 1.43947
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.38123
OPRK1 opioid receptor, kappa 1 1.37774
CRH corticotropin releasing hormone 1.36684
TF transferrin 1.34722
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 1.33458
NPY neuropeptide Y 1.31231
FGD1 FYVE, RhoGEF and PH domain containing 1 1.30751
GGT2 gamma-glutamyltransferase 2 1.30139
PHF3 PHD finger protein 3 1.30139
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.29352
GRIK3 glutamate receptor, ionotropic, kainate 3 1.28654
MAOA monoamine oxidase A 1.24515
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 1.24211
SERINC2 serine incorporator 2 1.23299
DRD1 dopamine receptor D1 1.23256
PDYN prodynorphin 1.19618
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.19618
PCNX pecanex homolog (Drosophila) 1.19014
CRHR1 corticotropin releasing hormone receptor 1 1.18712
CNR1 cannabinoid receptor 1 (brain) 1.17121
ANKRD7 ankyrin repeat domain 7 1.16692
FSIP2 fibrous sheath interacting protein 2 1.16692
TESK2 testis-specific kinase 2 1.16692
OR51L1 olfactory receptor, family 51, subfamily L, member 1 1.16692
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.16606
TAS2R16 taste receptor, type 2, member 16 1.15922
BDNF brain-derived neurotrophic factor 1.14857
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.14051
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.12445
GHRL ghrelin/obestatin prepropeptide 1.12108
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.1194
POMC proopiomelanocortin 1.11519
DRD3 dopamine receptor D3 1.10468
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.07404
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.06648
TPH2 tryptophan hydroxylase 2 1.06606
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.0627
C1QTNF7 C1q and tumor necrosis factor related protein 7 1.05765
MTIF2 mitochondrial translational initiation factor 2 1.05765
TTC12 tetratricopeptide repeat domain 12 1.0463
COMT catechol-O-methyltransferase 1.04167
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.03872
NRD1 nardilysin (N-arginine dibasic convertase) 1.02271
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.02229
TPH1 tryptophan hydroxylase 1 1.01849
MAOB monoamine oxidase B 1.01849
IPO11 importin 11 1.01427
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.00161
PKNOX2 PBX/knotted 1 homeobox 2 1.00119
CASC4 cancer susceptibility candidate 4 0.994439
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.96918
CCDC63 coiled-coil domain containing 63 0.963309
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.960797
C15ORF53 chromosome 15 open reading frame 53 0.924626
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 0.912257
GRM3 glutamate receptor, metabotropic 3 0.906498
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.888848
SRRD SRR1 domain containing 0.882701
ARID5A AT rich interactive domain 5A (MRF1-like) 0.879424
GRIK1 glutamate receptor, ionotropic, kainate 1 0.874919
DTWD2 DTW domain containing 2 0.870825
TMEM108 transmembrane protein 108 0.870825
PNOC prepronociceptin 0.866731
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.862637
THSD7B thrombospondin, type I, domain containing 7B 0.858543
GRM7 glutamate receptor, metabotropic 7 0.856905
C15ORF32 chromosome 15 open reading frame 32 0.843392
OSBPL5 oxysterol binding protein-like 5 0.840934
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.835198
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.833148
ADCY2 adenylate cyclase 2 (brain) 0.820026
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.808129
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.806898
UBAP2 ubiquitin associated protein 2 0.801974
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.799513
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.792951
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.786394
TAGLN3 transgelin 3 0.779432
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.778613
NPY2R neuropeptide Y receptor Y2 0.77575
ASTN1 astrotactin 1 0.772887
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.768393
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 0.761454
ZCCHC14 zinc finger, CCHC domain containing 14 0.758601
MANEA mannosidase, endo-alpha 0.757786
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.75412
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.744766
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 0.738271
STON2 stonin 2 0.735838
DSCAML1 Down syndrome cell adhesion molecule like 1 0.730976
OPN3 opsin 3 0.730571
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 0.720865
TAS2R38 taste receptor, type 2, member 38 0.719654
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.71925
GHSR growth hormone secretagogue receptor 0.709975
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 0.708364
TACR1 tachykinin receptor 1 0.69751
PECR peroxisomal trans-2-enoyl-CoA reductase 0.695103
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.693098
DCXR dicarbonyl/L-xylulose reductase 0.690293
ARC activity-regulated cytoskeleton-associated protein 0.682693
ABLIM1 actin binding LIM protein 1 0.678302
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.67113
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.670732
KLF11 Kruppel-like factor 11 0.666358
GLRA3 glycine receptor, alpha 3 0.665563
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.664372
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.664372
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.661594
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.657234
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.656046
GRM8 glutamate receptor, metabotropic 8 0.643404
THEMIS thymocyte selection associated 0.637889
AUTS2 autism susceptibility candidate 2 0.629635
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.628457
GPR55 G protein-coupled receptor 55 0.628065
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.628065
ADRA2A adrenoceptor alpha 2A 0.624535
ADCY7 adenylate cyclase 7 0.619051
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.617486
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.613574
CRHBP corticotropin releasing hormone binding protein 0.610838
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.610838
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 0.606933
EYS eyes shut homolog (Drosophila) 0.606543
ARL15 ADP-ribosylation factor-like 15 0.60225
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.59991
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.596012
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.595233
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.593674
CSMD2 CUB and Sushi multiple domains 2 0.590558
RFX4 regulatory factor X, 4 (influences HLA class II expression) 0.590558
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.590169
LEP leptin 0.589779
MREG melanoregulin 0.589001
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.582773
AGPS alkylglycerone phosphate synthase 0.576939
GRID1 glutamate receptor, ionotropic, delta 1 0.574217
MEA1 male-enhanced antigen 1 0.572662
ANAPC1 anaphase promoting complex subunit 1 0.569552
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.565666
NAP1L4 nucleosome assembly protein 1-like 4 0.562169
PENK proenkephalin 0.559839
LVRN laeverin 0.558674
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.550911
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.549359
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.542379
TNN tenascin N 0.540442
CREB1 cAMP responsive element binding protein 1 0.536957
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.536183
UNC79 unc-79 homolog (C. elegans) 0.532701
ZNF699 zinc finger protein 699 0.532314
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.528835
PDE10A phosphodiesterase 10A 0.522273
FTO fat mass and obesity associated 0.520346
DNASE2B deoxyribonuclease II beta 0.513417
PLCL1 phospholipase C-like 1 0.509959
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.509192
MGLL monoglyceride lipase 0.503824
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.501527
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.501527
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.499231
CINP cyclin-dependent kinase 2 interacting protein 0.496939
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.49274
HOMER2 homer scaffolding protein 2 0.489311
PRL prolactin 0.482084
PRKG2 protein kinase, cGMP-dependent, type II 0.479047
NALCN sodium leak channel, non selective 0.477151
DUSP8 dual specificity phosphatase 8 0.472982
GATA4 GATA binding protein 4 0.468819
FAAH fatty acid amide hydrolase 0.456732
DRD5 dopamine receptor D5 0.453716
NPS neuropeptide S 0.453339
HRH3 histamine receptor H3 0.452208
TRH thyrotropin-releasing hormone 0.452208
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.451078
HES2 hes family bHLH transcription factor 2 0.445429
SGCE sarcoglycan, epsilon 0.443171
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.441666
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.440162
RGS19 regulator of G-protein signaling 19 0.439786
LARS leucyl-tRNA synthetase 0.43753
MARK1 MAP/microtubule affinity-regulating kinase 1 0.436402
ADCY8 adenylate cyclase 8 (brain) 0.435275
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.433397
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.433021
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 0.432646
C19ORF26 chromosome 19 open reading frame 26 0.426265
GLUD2 glutamate dehydrogenase 2 0.42289
GAGE12F G antigen 12F 0.42139
OPRL1 opiate receptor-like 1 0.419142
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.415024
FGD4 FYVE, RhoGEF and PH domain containing 4 0.415024
KDM4C lysine (K)-specific demethylase 4C 0.41465
NEUROD2 neuronal differentiation 2 0.414276
CCKBR cholecystokinin B receptor 0.412031
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.410535
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.409787
GAL galanin/GMAP prepropeptide 0.407919
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.404931
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.398589
TH tyrosine hydroxylase 0.391513
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.390397
HYLS1 hydrolethalus syndrome 1 0.378143
NPY5R neuropeptide Y receptor Y5 0.377773
INADL InaD-like (Drosophila) 0.377031
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 0.373698
GRM2 glutamate receptor, metabotropic 2 0.373328
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.372587
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.372587
CRHR2 corticotropin releasing hormone receptor 2 0.369997
EFNA5 ephrin-A5 0.369628
SYNE1 spectrin repeat containing, nuclear envelope 1 0.367779
KANK1 KN motif and ankyrin repeat domains 1 0.365562
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.364824
CCDC88A coiled-coil domain containing 88A 0.363347
SALL2 spalt-like transcription factor 2 0.357814
GALR3 galanin receptor 3 0.355604
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.355604
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.354131
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.353395
UCN3 urocortin 3 0.353027
TFIP11 tuftelin interacting protein 11 0.353027
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.347144
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.345308
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 0.340173
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.331025
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.32701
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.325916
PDLIM5 PDZ and LIM domain 5 0.324094
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.316819
NLGN4X neuroligin 4, X-linked 0.313189
DACT3 dishevelled-binding antagonist of beta-catenin 3 0.312827
CCKAR cholecystokinin A receptor 0.304503
AKAP9 A kinase (PRKA) anchor protein 9 0.302698
NRXN3 neurexin 3 0.302337
AKR1C3 aldo-keto reductase family 1, member C3 0.300173
NGF nerve growth factor (beta polypeptide) 0.300173
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.299452
RXRB retinoid X receptor, beta 0.299092
ITGAD integrin, alpha D 0.296211
RNF19B ring finger protein 19B 0.295851
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.295492
CNOT2 CCR4-NOT transcription complex, subunit 2 0.295132
NPPA natriuretic peptide A 0.295132
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.295132
ACSL4 acyl-CoA synthetase long-chain family member 4 0.294772
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.287593
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.28616
CNTN4 contactin 4 0.283655
CNTN6 contactin 6 0.274021
MAP6 microtubule-associated protein 6 0.268687
FBXO2 F-box protein 2 0.268332
GRM1 glutamate receptor, metabotropic 1 0.267977
TOR1A torsin family 1, member A (torsin A) 0.267977
TAC1 tachykinin, precursor 1 0.260184
NCAM1 neural cell adhesion molecule 1 0.25983
NFYA nuclear transcription factor Y, alpha 0.255241
CYTL1 cytokine-like 1 0.252774
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.250663
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.245396
CNR2 cannabinoid receptor 2 (macrophage) 0.244696
SKI SKI proto-oncogene 0.244345
NPY1R neuropeptide Y receptor Y1 0.237009
PNPLA3 patatin-like phospholipase domain containing 3 0.23492
CDH13 cadherin 13 0.231102
GALR1 galanin receptor 1 0.230755
TAC3 tachykinin 3 0.212271
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.207578
LTBP1 latent transforming growth factor beta binding protein 1 0.20658
ALLC allantoicase 0.204923
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.199681
ADCY1 adenylate cyclase 1 (brain) 0.199356
GALR2 galanin receptor 2 0.198064
FOS FBJ murine osteosarcoma viral oncogene homolog 0.197742
ADCY3 adenylate cyclase 3 0.197742
CHRM1 cholinergic receptor, muscarinic 1 0.19582
PER2 period circadian clock 2 0.192971
BPI bactericidal/permeability-increasing protein 0.191097
THAP1 THAP domain containing, apoptosis associated protein 1 0.189551
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.189551
AVP arginine vasopressin 0.188326
LATS1 large tumor suppressor kinase 1 0.185016
LMO1 LIM domain only 1 (rhombotin 1) 0.184128
GRIK4 glutamate receptor, ionotropic, kainate 4 0.181798
GAGE12I G antigen 12I 0.180084
ALYREF Aly/REF export factor 0.180084
SKP1 S-phase kinase-associated protein 1 0.178403
GRM5 glutamate receptor, metabotropic 5 0.177029
HOMER1 homer scaffolding protein 1 0.174354
CD4 CD4 molecule 0.172799
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.172799
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 0.172291
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.164786
C1QBP complement component 1, q subcomponent binding protein 0.162908
SOS1 son of sevenless homolog 1 (Drosophila) 0.161139
TACR3 tachykinin receptor 3 0.160948
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.160387
HIP1 huntingtin interacting protein 1 0.158951
ADCY5 adenylate cyclase 5 0.157765