alcohol dependence Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)|Disorders related to or resulting from abuse or mis-use of alcohol. (Experimental Factor Ontology, EFO_0003829)
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Genes

28 genes associated with the disease alcohol dependence in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CAST calpastatin
CC2D2B coiled-coil and C2 domain containing 2B
CCKAR cholecystokinin A receptor
CNR1 cannabinoid receptor 1 (brain)
DRD2 dopamine receptor D2
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GRIK3 glutamate receptor, ionotropic, kainate 3
GRM5 glutamate receptor, metabotropic 5
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NPY neuropeptide Y
PECR peroxisomal trans-2-enoyl-CoA reductase
PKNOX2 PBX/knotted 1 homeobox 2
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TPK1 thiamin pyrophosphokinase 1
ZNF285 zinc finger protein 285