alcoholism Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
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Genes

430 genes associated with the disease alcoholism in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTN4 actinin, alpha 4
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADRB2 adrenoceptor beta 2, surface
AFAP1L2 actin filament associated protein 1-like 2
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
AKR1C4 aldo-keto reductase family 1, member C4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALPK1 alpha-kinase 1
ANK2 ankyrin 2, neuronal
ANKK1 ankyrin repeat and kinase domain containing 1
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AP1AR adaptor-related protein complex 1 associated regulatory protein
APOE apolipoprotein E
AR androgen receptor
ARHGAP15 Rho GTPase activating protein 15
ARSA arylsulfatase A
ARSJ arylsulfatase family, member J
ASIC2 acid sensing (proton gated) ion channel 2
ASPA aspartoacylase
ATP7B ATPase, Cu++ transporting, beta polypeptide
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BMPR1B bone morphogenetic protein receptor, type IB
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTBD16 BTB (POZ) domain containing 16
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C15ORF32 chromosome 15 open reading frame 32
C4ORF3 chromosome 4 open reading frame 3
C4ORF32 chromosome 4 open reading frame 32
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARS cysteinyl-tRNA synthetase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV3 caveolin 3
CCBE1 collagen and calcium binding EGF domains 1
CCDC109B coiled-coil domain containing 109B
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CCNT1 cyclin T1
CD53 CD53 molecule
CDH13 cadherin 13
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPE centromere protein E, 312kDa
CFI complement factor I
CHN1 chimerin 1
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CKAP2L cytoskeleton associated protein 2-like
CNBD1 cyclic nucleotide binding domain containing 1
CNGB1 cyclic nucleotide gated channel beta 1
CNR1 cannabinoid receptor 1 (brain)
CNTN4 contactin 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A1 collagen, type I, alpha 1
COL25A1 collagen, type XXV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COMT catechol-O-methyltransferase
CPLX1 complexin 1
CPQ carboxypeptidase Q
CREB1 cAMP responsive element binding protein 1
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CSMD2 CUB and Sushi multiple domains 2
CSRNP3 cysteine-serine-rich nuclear protein 3
CTNNA2 catenin (cadherin-associated protein), alpha 2
CUTC cutC copper transporter
CXCR2 chemokine (C-X-C motif) receptor 2
CXXC4 CXXC finger protein 4
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1
DCC DCC netrin 1 receptor
DDO D-aspartate oxidase
DHFR dihydrofolate reductase
DICER1 dicer 1, ribonuclease type III
DKK2 dickkopf WNT signaling pathway inhibitor 2
DLG1 discs, large homolog 1 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DMP1 dentin matrix acidic phosphoprotein 1
DOCK2 dedicator of cytokinesis 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DSCAML1 Down syndrome cell adhesion molecule like 1
DSPP dentin sialophosphoprotein
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EFHC1 EF-hand domain (C-terminal) containing 1
EGF epidermal growth factor
EHBP1 EH domain binding protein 1
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
EMB embigin
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHA7 EPH receptor A7
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERCC4 excision repair cross-complementation group 4
ERMN ermin, ERM-like protein
ESR1 estrogen receptor 1
ETNPPL ethanolamine-phosphate phospho-lyase
EYA2 EYA transcriptional coactivator and phosphatase 2
FABP2 fatty acid binding protein 2, intestinal
FAF1 Fas (TNFRSF6) associated factor 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FBLN2 fibulin 2
FBLN5 fibulin 5
FBN2 fibrillin 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGF5 fibroblast growth factor 5
FHIT fragile histidine triad
FKBP5 FK506 binding protein 5
FLNB filamin B, beta
FLT3 fms-related tyrosine kinase 3
FOXC2 forkhead box C2
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GALR1 galanin receptor 1
GAR1 GAR1 ribonucleoprotein
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GLI2 GLI family zinc finger 2
GLRA3 glycine receptor, alpha 3
GLRB glycine receptor, beta
GLUD1 glutamate dehydrogenase 1
GMPS guanine monphosphate synthase
GNAS GNAS complex locus
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK5 G protein-coupled receptor kinase 5
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GSK3B glycogen synthase kinase 3 beta
GSTCD glutathione S-transferase, C-terminal domain containing
GSTZ1 glutathione S-transferase zeta 1
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
H2AFY H2A histone family, member Y
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HADH hydroxyacyl-CoA dehydrogenase
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HGD homogentisate 1,2-dioxygenase
HIP1 huntingtin interacting protein 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HLF hepatic leukemia factor
HMGA1 high mobility group AT-hook 1
HNMT histamine N-methyltransferase
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IDO1 indoleamine 2,3-dioxygenase 1
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IMPG1 interphotoreceptor matrix proteoglycan 1
INTS12 integrator complex subunit 12
IRF8 interferon regulatory factor 8
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KANSL2 KAT8 regulatory NSL complex subunit 2
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1191 KIAA1191
KIF13B kinesin family member 13B
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
KRT1 keratin 1, type II
KRT76 keratin 76, type II
LAMB1 laminin, beta 1
LARGE like-glycosyltransferase
LARP7 La ribonucleoprotein domain family, member 7
LCLAT1 lysocardiolipin acyltransferase 1
LEF1 lymphoid enhancer-binding factor 1
LHX6 LIM homeobox 6
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
LRP2 low density lipoprotein receptor-related protein 2
LRPPRC leucine-rich pentatricopeptide repeat containing
LSP1 lymphocyte-specific protein 1
LYPD6B LY6/PLAUR domain containing 6B
MACROD2 MACRO domain containing 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MANBA mannosidase, beta A, lysosomal
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAT1A methionine adenosyltransferase I, alpha
MATN3 matrilin 3
MB21D2 Mab-21 domain containing 2
MBNL2 muscleblind-like splicing regulator 2
MEMO1 mediator of cell motility 1
METTL14 methyltransferase like 14
METTL4 methyltransferase like 4
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MICALCL MICAL C-terminal like
MICU3 mitochondrial calcium uptake family, member 3
MMD monocyte to macrophage differentiation-associated
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTIF2 mitochondrial translational initiation factor 2
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTSS1 metastasis suppressor 1
MUC7 mucin 7, secreted
MYL5 myosin, light chain 5, regulatory
MYO16 myosin XVI
MYO6 myosin VI
MYO7A myosin VIIA
MYOZ2 myozenin 2
NAP1L4 nucleosome assembly protein 1-like 4
NBEAL1 neurobeachin-like 1
NCAM1 neural cell adhesion molecule 1
NCAM2 neural cell adhesion molecule 2
NDNF neuron-derived neurotrophic factor
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NEUROG2 neurogenin 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLGN1 neuroligin 1
NOS1 nitric oxide synthase 1 (neuronal)
NPAS3 neuronal PAS domain protein 3
NPNT nephronectin
NPY neuropeptide Y
NRP1 neuropilin 1
NRXN1 neurexin 1
NRXN3 neurexin 3
NTSR2 neurotensin receptor 2
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OPTC opticin
OR52A1 olfactory receptor, family 52, subfamily A, member 1
OSBPL5 oxysterol binding protein-like 5
OSTC oligosaccharyltransferase complex subunit (non-catalytic)
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCDH15 protocadherin-related 15
PCLO piccolo presynaptic cytomatrix protein
PCNX pecanex homolog (Drosophila)
PDE10A phosphodiesterase 10A
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDE5A phosphodiesterase 5A, cGMP-specific
PDE7B phosphodiesterase 7B
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDZD7 PDZ domain containing 7
PELP1 proline, glutamate and leucine rich protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKNOX2 PBX/knotted 1 homeobox 2
PLA2G12A phospholipase A2, group XIIA
PLCE1 phospholipase C, epsilon 1
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PMF1 polyamine-modulated factor 1
POU6F2 POU class 6 homeobox 2
PPA2 pyrophosphatase (inorganic) 2
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDM5 PR domain containing 5
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCA protein kinase C, alpha
PRKG1 protein kinase, cGMP-dependent, type I
PRKG2 protein kinase, cGMP-dependent, type II
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRR5L proline rich 5 like
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRR protein tyrosine phosphatase, receptor type, R
PTPRS protein tyrosine phosphatase, receptor type, S
PTPRT protein tyrosine phosphatase, receptor type, T
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PURB purine-rich element binding protein B
PUS10 pseudouridylate synthase 10
QDPR quinoid dihydropteridine reductase
RAD51AP1 RAD51 associated protein 1
RAD52 RAD52 homolog (S. cerevisiae)
RBM5 RNA binding motif protein 5
RBM6 RNA binding motif protein 6
REG3A regenerating islet-derived 3 alpha
REN renin
RFC1 replication factor C (activator 1) 1, 145kDa
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
RORB RAR-related orphan receptor B
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPL34 ribosomal protein L34
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRH retinal pigment epithelium-derived rhodopsin homolog
RYR3 ryanodine receptor 3
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEC24B SEC24 family member B
SEC24D SEC24 family member D
SELE selectin E
SELL selectin L
SEZ6L seizure related 6 homolog (mouse)-like
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1
SGMS2 sphingomyelin synthase 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SIGMAR1 sigma non-opioid intracellular receptor 1
SIMC1 SUMO-interacting motifs containing 1
SIX3 SIX homeobox 3
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14
SLC37A3 solute carrier family 37, member 3
SLC39A10 solute carrier family 39 (zinc transporter), member 10
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SOD1 superoxide dismutase 1, soluble
SORBS1 sorbin and SH3 domain containing 1
SOX5 SRY (sex determining region Y)-box 5
SSTR5 somatostatin receptor 5
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
SURF1 surfeit 1
SYNGR1 synaptogyrin 1
SYNPO synaptopodin
SYNPO2 synaptopodin 2
TACR3 tachykinin receptor 3
TBCA tubulin folding cofactor A
TBCE tubulin folding cofactor E
TBCK TBC1 domain containing kinase
TCN2 transcobalamin II
TERF2 telomeric repeat binding factor 2
TET2 tet methylcytosine dioxygenase 2
TGFA transforming growth factor, alpha
TGFB2 transforming growth factor, beta 2
TGOLN2 trans-golgi network protein 2
TH tyrosine hydroxylase
TIFA TRAF-interacting protein with forkhead-associated domain
TLN2 talin 2
TMEM132C transmembrane protein 132C
TNF tumor necrosis factor
TOP2B topoisomerase (DNA) II beta 180kDa
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRAM1L1 translocation associated membrane protein 1-like 1
TRIB2 tribbles pseudokinase 2
TSC2 tuberous sclerosis 2
TTC12 tetratricopeptide repeat domain 12
TTL tubulin tyrosine ligase
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UGDH UDP-glucose 6-dehydrogenase
UGT8 UDP glycosyltransferase 8
UNC5C unc-5 homolog C (C. elegans)
USP53 ubiquitin specific peptidase 53
VCAN versican
VWC2L von Willebrand factor C domain containing protein 2-like
VWF von Willebrand factor
WDR7 WD repeat domain 7
XPC xeroderma pigmentosum, complementation group C
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZFAND3 zinc finger, AN1-type domain 3
ZFHX3 zinc finger homeobox 3
ZGRF1 zinc finger, GRF-type containing 1
ZNF532 zinc finger protein 532
ZNF638 zinc finger protein 638