aldosterone Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. (Chemical Entities of Biological Interest Ontology, CHEBI_27584)
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Genes

94 genes co-occuring with the biological term aldosterone in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADCY10 adenylate cyclase 10 (soluble)
ADD1 adducin 1 (alpha)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX12 arachidonate 12-lipoxygenase
AQP2 aquaporin 2 (collecting duct)
ASCL4 achaete-scute family bHLH transcription factor 4
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BMP6 bone morphogenetic protein 6
C1QTNF1 C1q and tumor necrosis factor related protein 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGA glycoprotein hormones, alpha polypeptide
CREB1 cAMP responsive element binding protein 1
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DRD4 dopamine receptor D4
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
ELN elastin
GH1 growth hormone 1
GNRHR gonadotropin-releasing hormone receptor
GPER1 G protein-coupled estrogen receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK9 potassium channel, two pore domain subfamily K, member 9
KL klotho
KLK1 kallikrein 1
LGALS3 lectin, galactoside-binding, soluble, 3
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR21 microRNA 21
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
PCP4 Purkinje cell protein 4
PER1 period circadian clock 1
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKD1 protein kinase D1
PRSS8 protease, serine, 8
REN renin
RGS2 regulator of G-protein signaling 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
TDGF1 teratocarcinoma-derived growth factor 1
TNF tumor necrosis factor
TRPM7 transient receptor potential cation channel, subfamily M, member 7
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
UTS2R urotensin 2 receptor
VSNL1 visinin-like 1
WNT4 wingless-type MMTV integration site family, member 4