alexidine-2576 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the alexidine-2576 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
AZI2 5-azacytidine induced 2
CCPG1 cell cycle progression 1
CDC25C cell division cycle 25C
CLCN4 chloride channel, voltage-sensitive 4
CLGN calmegin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL15A1 collagen, type XV, alpha 1
COPE coatomer protein complex, subunit epsilon
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DZIP3 DAZ interacting zinc finger protein 3
EGR3 early growth response 3
ENAH enabled homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FCAR Fc fragment of IgA receptor
FCMR Fc fragment of IgM receptor
FLRT2 fibronectin leucine rich transmembrane protein 2
GPR19 G protein-coupled receptor 19
GRB10 growth factor receptor-bound protein 10
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
ICK intestinal cell (MAK-like) kinase
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INHBE inhibin, beta E
ITGB5 integrin, beta 5
KDM7A lysine (K)-specific demethylase 7A
KIAA1107 KIAA1107
KIF18A kinesin family member 18A
KLF2 Kruppel-like factor 2
KRCC1 lysine-rich coiled-coil 1
LARP7 La ribonucleoprotein domain family, member 7
LAT2 linker for activation of T cells family, member 2
LEF1 lymphoid enhancer-binding factor 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LPAR1 lysophosphatidic acid receptor 1
LY96 lymphocyte antigen 96
MCC mutated in colorectal cancers
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MTL5 metallothionein-like 5, testis-specific (tesmin)
N4BP2L2 NEDD4 binding protein 2-like 2
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPC1 Niemann-Pick disease, type C1
OLAH oleoyl-ACP hydrolase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PCNX pecanex homolog (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PLSCR1 phospholipid scramblase 1
PRAMEF11 PRAME family member 11
PSPH phosphoserine phosphatase
PYGB phosphorylase, glycogen; brain
RGS10 regulator of G-protein signaling 10
RIMS3 regulating synaptic membrane exocytosis 3
RNFT1 ring finger protein, transmembrane 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCG5 secretogranin V
SIRT1 sirtuin 1
SLC16A4 solute carrier family 16, member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TLK1 tousled-like kinase 1
TMEM180 transmembrane protein 180
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TRA T cell receptor alpha locus
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
ULBP2 UL16 binding protein 2
ZBTB20 zinc finger and BTB domain containing 20
ZNF276 zinc finger protein 276

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGRA3 adhesion G protein-coupled receptor A3
ADGRE2 adhesion G protein-coupled receptor E2
ADM adrenomedullin
ADORA3 adenosine A3 receptor
AEN apoptosis enhancing nuclease
AIRE autoimmune regulator
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARRB1 arrestin, beta 1
C10ORF2 chromosome 10 open reading frame 2
C3 complement component 3
C7 complement component 7
CABP2 calcium binding protein 2
CBR3 carbonyl reductase 3
CBX8 chromobox homolog 8
CCL21 chemokine (C-C motif) ligand 21
CD69 CD69 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDR2L cerebellar degeneration-related protein 2-like
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DHODH dihydroorotate dehydrogenase (quinone)
DPYS dihydropyrimidinase
EPN1 epsin 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM163A family with sequence similarity 163, member A
FAM86C1 family with sequence similarity 86, member C1
FBXO31 F-box protein 31
FBXO40 F-box protein 40
FKBP5 FK506 binding protein 5
FOXN2 forkhead box N2
FRMPD1 FERM and PDZ domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GIPR gastric inhibitory polypeptide receptor
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GSN-AS1 GSN antisense RNA 1
GSTT1 glutathione S-transferase theta 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H3I histone cluster 1, H3i
HP haptoglobin
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGKV3-20 immunoglobulin kappa variable 3-20
IL12RB1 interleukin 12 receptor, beta 1
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
JMJD4 jumonji domain containing 4
KIAA1456 KIAA1456
KIF17 kinesin family member 17
LAMP3 lysosomal-associated membrane protein 3
LIME1 Lck interacting transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LY6D lymphocyte antigen 6 complex, locus D
MAGOHB mago-nashi homolog B (Drosophila)
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOXD1 monooxygenase, DBH-like 1
MSC musculin
NDE1 nudE neurodevelopment protein 1
NEUROD4 neuronal differentiation 4
NPPB natriuretic peptide B
NRAP nebulin-related anchoring protein
NTF3 neurotrophin 3
NTHL1 nth endonuclease III-like 1 (E. coli)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PBOV1 prostate and breast cancer overexpressed 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHACTR1 phosphatase and actin regulator 1
PLA2G1B phospholipase A2, group IB (pancreas)
PMEL premelanosome protein
PMFBP1 polyamine modulated factor 1 binding protein 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRDM12 PR domain containing 12
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RPP25 ribonuclease P/MRP 25kDa subunit
SCG2 secretogranin II
SCN10A sodium channel, voltage gated, type X alpha subunit
SDF2L1 stromal cell-derived factor 2-like 1
SEC14L5 SEC14-like 5 (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STRA13 stimulated by retinoic acid 13
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYT13 synaptotagmin XIII
TAS2R1 taste receptor, type 2, member 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TMEM120B transmembrane protein 120B
TNNT1 troponin T type 1 (skeletal, slow)
TPM3 tropomyosin 3
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSPAN5 tetraspanin 5
WASF3 WAS protein family, member 3
ZBTB33 zinc finger and BTB domain containing 33