alfuzosin-3203 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the alfuzosin-3203 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADRB1 adrenoceptor beta 1
ARMC4 armadillo repeat containing 4
ASIC4 acid sensing (proton gated) ion channel family member 4
BTNL3 butyrophilin-like 3
C10ORF12 chromosome 10 open reading frame 12
C2ORF27A chromosome 2 open reading frame 27A
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CCRL2 chemokine (C-C motif) receptor-like 2
CDHR2 cadherin-related family member 2
CDK19 cyclin-dependent kinase 19
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
COL3A1 collagen, type III, alpha 1
CORO2B coronin, actin binding protein, 2B
CPQ carboxypeptidase Q
CTGF connective tissue growth factor
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DOCK6 dedicator of cytokinesis 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ETV7 ets variant 7
FAM13C family with sequence similarity 13, member C
FBXL7 F-box and leucine-rich repeat protein 7
FN1 fibronectin 1
GAP43 growth associated protein 43
GLIPR1 GLI pathogenesis-related 1
GLP1R glucagon-like peptide 1 receptor
GLRA3 glycine receptor, alpha 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSTTP1 glutathione S-transferase theta pseudogene 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBS1L HBS1-like translational GTPase
HIF3A hypoxia inducible factor 3, alpha subunit
IFT54 intraflagellar transport 54
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IL12B interleukin 12B
JMJD4 jumonji domain containing 4
JPH3 junctophilin 3
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KIAA0087 KIAA0087
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMTK1 lemur tail kinase 1
LPL lipoprotein lipase
LRRC8B leucine rich repeat containing 8 family, member B
LRRK1 leucine-rich repeat kinase 1
MEG3 maternally expressed 3 (non-protein coding)
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MTA1 metastasis associated 1
MTRF1L mitochondrial translational release factor 1-like
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPAS1 neuronal PAS domain protein 1
NPAS2 neuronal PAS domain protein 2
NPTX1 neuronal pentraxin I
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NYNRIN NYN domain and retroviral integrase containing
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDHGA1 protocadherin gamma subfamily A, 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PKD2L2 polycystic kidney disease 2-like 2
PKNOX1 PBX/knotted 1 homeobox 1
POU1F1 POU class 1 homeobox 1
POU6F1 POU class 6 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROL1 proline rich, lacrimal 1
PRX periaxin
RAB30 RAB30, member RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSU1 Ras suppressor protein 1
RUNX1 runt-related transcription factor 1
SAFB scaffold attachment factor B
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SPRR1A small proline-rich protein 1A
SYN3 synapsin III
SYNPO synaptopodin
TAS2R10 taste receptor, type 2, member 10
TK2 thymidine kinase 2, mitochondrial
TMEM144 transmembrane protein 144
TOX thymocyte selection-associated high mobility group box
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC7 transient receptor potential cation channel, subfamily C, member 7
ZC3H7B zinc finger CCCH-type containing 7B
ZNF280A zinc finger protein 280A
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
AMT aminomethyltransferase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ART1 ADP-ribosyltransferase 1
ASAP1-IT1 ASAP1 intronic transcript 1
BAHCC1 BAH domain and coiled-coil containing 1
BMP4 bone morphogenetic protein 4
C11ORF63 chromosome 11 open reading frame 63
C17ORF80 chromosome 17 open reading frame 80
C6ORF47 chromosome 6 open reading frame 47
CA5BP1 carbonic anhydrase VB pseudogene 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCN2 chloride channel, voltage-sensitive 2
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CST6 cystatin E/M
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DSCAM Down syndrome cell adhesion molecule
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EMID1 EMI domain containing 1
ETAA1 Ewing tumor-associated antigen 1
FADS2 fatty acid desaturase 2
FBXL15 F-box and leucine-rich repeat protein 15
FEM1C fem-1 homolog c (C. elegans)
FLJ22184
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALK1 galactokinase 1
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLI3 GLI family zinc finger 3
GPR1 G protein-coupled receptor 1
HIST1H2AL histone cluster 1, H2al
HMOX1 heme oxygenase 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXD11 homeobox D11
IL15RA interleukin 15 receptor, alpha
IQSEC2 IQ motif and Sec7 domain 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA10 integrin, alpha 10
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KLF2 Kruppel-like factor 2
KLF7 Kruppel-like factor 7 (ubiquitous)
LDHB lactate dehydrogenase B
LMO2 LIM domain only 2 (rhombotin-like 1)
LPXN leupaxin
LYZ lysozyme
LZTS3 leucine zipper, putative tumor suppressor family member 3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MUC3A mucin 3A, cell surface associated
MVP major vault protein
MYO1E myosin IE
NIPAL2 NIPA-like domain containing 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB13 protocadherin beta 13
PDE12 phosphodiesterase 12
PLEK2 pleckstrin 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMT2 protein-O-mannosyltransferase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS16 protease, serine, 16 (thymus)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASAL1 RAS protein activator like 1 (GAP1 like)
RECQL4 RecQ protein-like 4
REEP4 receptor accessory protein 4
RFTN1 raftlin, lipid raft linker 1
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RPH3AL rabphilin 3A-like (without C2 domains)
SAV1 salvador family WW domain containing protein 1
SCPEP1 serine carboxypeptidase 1
SDC3 syndecan 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SRD5A3 steroid 5 alpha-reductase 3
STAG3 stromal antigen 3
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D17 TBC1 domain family, member 17
TCTN2 tectonic family member 2
TICAM1 toll-like receptor adaptor molecule 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
UBXN6 UBX domain protein 6
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
VGF VGF nerve growth factor inducible
XAB2 XPA binding protein 2
ZNF324 zinc finger protein 324
ZNF428 zinc finger protein 428
ZNF696 zinc finger protein 696
ZNF8 zinc finger protein 8