alk Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description anaplastic lymphoma receptor tyrosine kinase|This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 238)
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Genes

73 genes co-occuring with the biological term alk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BIRC5 baculoviral IAP repeat containing 5
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD99 CD99 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CXCL8 chemokine (C-X-C motif) ligand 8
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
EML4 echinoderm microtubule associated protein like 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
FHIT fragile histidine triad
FLOT1 flotillin 1
FOXO1 forkhead box O1
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1R insulin-like growth factor 1 receptor
IL9 interleukin 9
JAK3 Janus kinase 3
JUNB jun B proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRC7 leucine rich repeat containing 7
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK8 mitogen-activated protein kinase 8
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH9 myosin, heavy chain 9, non-muscle
NBAS neuroblastoma amplified sequence
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAX3 paired box 3
PAX7 paired box 7
PHOX2B paired-like homeobox 2b
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTN pleiotrophin
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RANBP2 RAN binding protein 2
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RET ret proto-oncogene
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHF Src homology 2 domain containing F
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STIP1 stress-induced phosphoprotein 1
TENM4 teneurin transmembrane protein 4
TGFB1 transforming growth factor, beta 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM132D transmembrane protein 132D
TNF tumor necrosis factor
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53 tumor protein p53
VASP vasodilator-stimulated phosphoprotein
VCL vinculin