alopecia areata Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type II disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots. (Human Disease Ontology, DOID_986)
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Genes

131 genes co-occuring with the disease alopecia areata in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CD4 CD4 molecule 1.24993
IFRD2 interferon-related developmental regulator 2 1.19791
IKZF4 IKAROS family zinc finger 4 (Eos) 1.14815
ULBP3 UL16 binding protein 3 1.14178
STX17 syntaxin 17 1.05807
AIRE autoimmune regulator 1.05345
CCDC88B coiled-coil domain containing 88B 1.03156
HLA-C major histocompatibility complex, class I, C 0.987271
ICAM1 intercellular adhesion molecule 1 0.97338
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 0.9238
TCHH trichohyalin 0.916787
OAT ornithine aminotransferase 0.861818
NPS neuropeptide S 0.807718
IL1A interleukin 1, alpha 0.774523
KRT15 keratin 15, type I 0.770435
HSPA1B heat shock 70kDa protein 1B 0.765943
FLG filaggrin 0.761047
HLA-B major histocompatibility complex, class I, B 0.742329
FASLG Fas ligand (TNF superfamily, member 6) 0.719654
KRT16 keratin 16, type I 0.706754
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.6939
MX1 MX dynamin-like GTPase 1 0.688692
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.684692
IL1RN interleukin 1 receptor antagonist 0.677504
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 0.677504
TNF tumor necrosis factor 0.672722
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.66199
KDM4A lysine (K)-specific demethylase 4A 0.631991
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.626888
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.623751
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.622967
TAC1 tachykinin, precursor 1 0.620226
SKIL SKI-like proto-oncogene 0.615921
HLA-DMB major histocompatibility complex, class II, DM beta 0.612011
KDM4C lysine (K)-specific demethylase 4C 0.609276
SETD7 SET domain containing (lysine methyltransferase) 7 0.604201
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.595233
HSPA1A heat shock 70kDa protein 1A 0.582384
POMC proopiomelanocortin 0.573828
IL1B interleukin 1, beta 0.57305
CXCR3 chemokine (C-X-C motif) receptor 3 0.569552
IL2RA interleukin 2 receptor, alpha 0.565277
IL2 interleukin 2 0.557897
LPP LIM domain containing preferred translocation partner in lipoma 0.557897
WDR11 WD repeat domain 11 0.554791
IL16 interleukin 16 0.554791
CREB3L4 cAMP responsive element binding protein 3-like 4 0.535796
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.534635
GNLY granulysin 0.530768
PRDX5 peroxiredoxin 5 0.525746
TPO thyroid peroxidase 0.522659
KDM4B lysine (K)-specific demethylase 4B 0.519961
CXCL10 chemokine (C-X-C motif) ligand 10 0.514956
HLA-A major histocompatibility complex, class I, A 0.513417
ICAM2 intercellular adhesion molecule 2 0.497703
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.49274
CXCL9 chemokine (C-X-C motif) ligand 9 0.483604
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.481705
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.480566
CRH corticotropin releasing hormone 0.479047
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.47374
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.446558
HDAC7 histone deacetylase 7 0.397843
KDM5A lysine (K)-specific demethylase 5A 0.377402
ICOSLG inducible T-cell co-stimulator ligand 0.375179
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.372217
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.366671
ORM1 orosomucoid 1 0.363347
IFNG interferon, gamma 0.362978
TLR1 toll-like receptor 1 0.359657
CD44 CD44 molecule (Indian blood group) 0.359657
FGF5 fibroblast growth factor 5 0.35082
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.341272
BTNL2 butyrophilin-like 2 0.33944
IL18R1 interleukin 18 receptor 1 0.331756
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.323002
TG thyroglobulin 0.322637
USP9X ubiquitin specific peptidase 9, X-linked 0.320817
CLEC16A C-type lectin domain family 16, member A 0.317909
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.312102
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.309928
MYBPC1 myosin binding protein C, slow type 0.30631
CRHR1 corticotropin releasing hormone receptor 1 0.305587
MBD4 methyl-CpG binding domain protein 4 0.303781
PTPRD protein tyrosine phosphatase, receptor type, D 0.30342
SPATA5 spermatogenesis associated 5 0.290462
EGLN2 egl-9 family hypoxia-inducible factor 2 0.282225
B3GAT1 beta-1,3-glucuronyltransferase 1 0.280082
MME membrane metallo-endopeptidase 0.275089
KRT6A keratin 6A, type II 0.274732
FCRL3 Fc receptor-like 3 0.266913
TACR1 tachykinin receptor 1 0.264785
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.262306
CCL27 chemokine (C-C motif) ligand 27 0.254536
LCK LCK proto-oncogene, Src family tyrosine kinase 0.253127
CALCA calcitonin-related polypeptide alpha 0.24996
PSIP1 PC4 and SFRS1 interacting protein 1 0.247852
MICA MHC class I polypeptide-related sequence A 0.24715
CD79A CD79a molecule, immunoglobulin-associated alpha 0.245046
CD40 CD40 molecule, TNF receptor superfamily member 5 0.244696
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.243645
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.223509
IL18BP interleukin 18 binding protein 0.222822
TBX21 T-box 21 0.218374
PMEL premelanosome protein 0.216332
JAK1 Janus kinase 1 0.209583
CRHR2 corticotropin releasing hormone receptor 2 0.209248
C5 complement component 5 0.205254
TGFB1 transforming growth factor, beta 1 0.200982
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.196139
TXNRD1 thioredoxin reductase 1 0.19582
CCR8 chemokine (C-C motif) receptor 8 0.189859
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.185016
CD19 CD19 molecule 0.182957
EREG epiregulin 0.181798
SHOX short stature homeobox 0.17952
CD80 CD80 molecule 0.175146
FOXP3 forkhead box P3 0.172038
SOD2 superoxide dismutase 2, mitochondrial 0.171785
FOXC2 forkhead box C2 0.171785
NELFCD negative elongation factor complex member C/D 0.171286
KRT17 keratin 17, type I 0.170789
KDM1A lysine (K)-specific demethylase 1A 0.168381
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.166768
TXNRD2 thioredoxin reductase 2 0.165655
SLITRK1 SLIT and NTRK-like family, member 1 0.164571
NCAM1 neural cell adhesion molecule 1 0.163938
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.162908
GCGR glucagon receptor 0.160948
OCA2 oculocutaneous albinism II 0.158951
TRAF1 TNF receptor-associated factor 1 0.158097