alpha-estradiol-1048 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-1048 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD2 abhydrolase domain containing 2
ABI2 abl-interactor 2
ACVR2B activin A receptor, type IIB
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARMC6 armadillo repeat containing 6
ARNT aryl hydrocarbon receptor nuclear translocator
ATP9A ATPase, class II, type 9A
BAGE B melanoma antigen
BLVRA biliverdin reductase A
C19ORF40 chromosome 19 open reading frame 40
C9ORF16 chromosome 9 open reading frame 16
CIC capicua transcriptional repressor
COL5A1 collagen, type V, alpha 1
CSNK1G1 casein kinase 1, gamma 1
CUL2 cullin 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAXX death-domain associated protein
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DET1 de-etiolated homolog 1 (Arabidopsis)
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLG3 discs, large homolog 3 (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
ECSIT ECSIT signalling integrator
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM149B1 family with sequence similarity 149, member B1
FYN FYN proto-oncogene, Src family tyrosine kinase
GPR19 G protein-coupled receptor 19
HLA-F major histocompatibility complex, class I, F
IMPAD1 inositol monophosphatase domain containing 1
INO80B INO80 complex subunit B
INPP5K inositol polyphosphate-5-phosphatase K
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JAG1 jagged 1
JRK Jrk homolog (mouse)
KCTD15 potassium channel tetramerization domain containing 15
KLK6 kallikrein-related peptidase 6
KRIT1 KRIT1, ankyrin repeat containing
LDB1 LIM domain binding 1
LMAN1 lectin, mannose-binding, 1
LRRC20 leucine rich repeat containing 20
MAN1A1 mannosidase, alpha, class 1A, member 1
MBD4 methyl-CpG binding domain protein 4
MOB1A MOB kinase activator 1A
MPZL2 myelin protein zero-like 2
MRPS18C mitochondrial ribosomal protein S18C
MVK mevalonate kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAP1L1 nucleosome assembly protein 1-like 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PEX1 peroxisomal biogenesis factor 1
PHF3 PHD finger protein 3
PHKB phosphorylase kinase, beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRLR prolactin receptor
PTMA prothymosin, alpha
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RBM6 RNA binding motif protein 6
RND2 Rho family GTPase 2
RPL38 ribosomal protein L38
RPS28 ribosomal protein S28
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC63 SEC63 homolog (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SENP5 SUMO1/sentrin specific peptidase 5
SETD1B SET domain containing 1B
SGK1 serum/glucocorticoid regulated kinase 1
SHARPIN SHANK-associated RH domain interactor
SMOX spermine oxidase
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SNUPN snurportin 1
SOCS5 suppressor of cytokine signaling 5
SOX3 SRY (sex determining region Y)-box 3
SPN sialophorin
STAG3 stromal antigen 3
STC1 stanniocalcin 1
STK3 serine/threonine kinase 3
STX16 syntaxin 16
SYNJ2 synaptojanin 2
SZRD1 SUZ RNA binding domain containing 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM194A transmembrane protein 194A
TMPRSS3 transmembrane protease, serine 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN5 tetraspanin 5
USF2 upstream transcription factor 2, c-fos interacting
VAC14 Vac14 homolog (S. cerevisiae)
VWA8 von Willebrand factor A domain containing 8
WDR61 WD repeat domain 61
WWOX WW domain containing oxidoreductase
ZBTB43 zinc finger and BTB domain containing 43
ZNF165 zinc finger protein 165
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AHR aryl hydrocarbon receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANAPC2 anaphase promoting complex subunit 2
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARCN1 archain 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP12 Rho GTPase activating protein 12
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASB6 ankyrin repeat and SOCS box containing 6
ASB7 ankyrin repeat and SOCS box containing 7
ATAD2B ATPase family, AAA domain containing 2B
ATG9A autophagy related 9A
ATP11B ATPase, class VI, type 11B
BAX BCL2-associated X protein
BRPF1 bromodomain and PHD finger containing, 1
BTBD3 BTB (POZ) domain containing 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBY1 chibby homolog 1 (Drosophila)
CCDC91 coiled-coil domain containing 91
CD3EAP CD3e molecule, epsilon associated protein
CERK ceramide kinase
CPNE1 copine I
DHCR24 24-dehydrocholesterol reductase
ECHDC3 enoyl CoA hydratase domain containing 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHD3 EH-domain containing 3
ENO2 enolase 2 (gamma, neuronal)
EPHA4 EPH receptor A4
FAM50B family with sequence similarity 50, member B
FAR2 fatty acyl CoA reductase 2
FBXW12 F-box and WD repeat domain containing 12
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD2 frizzled class receptor 2
GAA glucosidase, alpha; acid
GDAP2 ganglioside induced differentiation associated protein 2
GHR growth hormone receptor
GLMN glomulin, FKBP associated protein
GMCL1 germ cell-less, spermatogenesis associated 1
IER2 immediate early response 2
IGFBP6 insulin-like growth factor binding protein 6
INSIG2 insulin induced gene 2
KLHL26 kelch-like family member 26
KRT8P12 keratin 8 pseudogene 12
LHFPL2 lipoma HMGIC fusion partner-like 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP3 low density lipoprotein receptor-related protein 3
LYPD3 LY6/PLAUR domain containing 3
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MED22 mediator complex subunit 22
METRN meteorin, glial cell differentiation regulator
MPHOSPH8 M-phase phosphoprotein 8
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYH9 myosin, heavy chain 9, non-muscle
MYO9A myosin IXA
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NAP1L2 nucleosome assembly protein 1-like 2
NARFL nuclear prelamin A recognition factor-like
NME7 NME/NM23 family member 7
NMU neuromedin U
PANK4 pantothenate kinase 4
PGM1 phosphoglucomutase 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PYGB phosphorylase, glycogen; brain
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
REEP4 receptor accessory protein 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCAMP3 secretory carrier membrane protein 3
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SREBF1 sterol regulatory element binding transcription factor 1
STK16 serine/threonine kinase 16
SUCO SUN domain containing ossification factor
SYNJ2BP synaptojanin 2 binding protein
TBCC tubulin folding cofactor C
TOE1 target of EGR1, member 1 (nuclear)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53BP1 tumor protein p53 binding protein 1
TRIM45 tripartite motif containing 45
TRIP10 thyroid hormone receptor interactor 10
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TXNL4B thioredoxin-like 4B
UFSP2 UFM1-specific peptidase 2
WBP2 WW domain binding protein 2
WDR60 WD repeat domain 60
WFS1 Wolfram syndrome 1 (wolframin)
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YBX2 Y box binding protein 2
ZBTB10 zinc finger and BTB domain containing 10
ZCCHC6 zinc finger, CCHC domain containing 6
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF268 zinc finger protein 268
ZNF394 zinc finger protein 394