alpha-estradiol-1151 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the alpha-estradiol-1151 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACVR1B activin A receptor, type IB
ADGRA3 adhesion G protein-coupled receptor A3
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AREG amphiregulin
ARNTL aryl hydrocarbon receptor nuclear translocator-like
B9D2 B9 protein domain 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BLZF1 basic leucine zipper nuclear factor 1
C1ORF105 chromosome 1 open reading frame 105
CACTIN cactin, spliceosome C complex subunit
CADM1 cell adhesion molecule 1
CDK3 cyclin-dependent kinase 3
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLCA1 chloride channel accessory 1
CREM cAMP responsive element modulator
CXCR3 chemokine (C-X-C motif) receptor 3
DKK2 dickkopf WNT signaling pathway inhibitor 2
DSTYK dual serine/threonine and tyrosine protein kinase
DTNA dystrobrevin, alpha
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNB3 ephrin-B3
ELK1 ELK1, member of ETS oncogene family
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM149B1 family with sequence similarity 149, member B1
FAM3A family with sequence similarity 3, member A
FCHO1 FCH domain only 1
FCMR Fc fragment of IgM receptor
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD1 frizzled class receptor 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GNL1 guanine nucleotide binding protein-like 1
HEMK1 HemK methyltransferase family member 1
HIST2H2BE histone cluster 2, H2be
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
ITSN1 intersectin 1 (SH3 domain protein)
KIAA0753 KIAA0753
KLF6 Kruppel-like factor 6
KYNU kynureninase
LDB1 LIM domain binding 1
LMF2 lipase maturation factor 2
LPAR2 lysophosphatidic acid receptor 2
LRP2 low density lipoprotein receptor-related protein 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP1A microtubule-associated protein 1A
MAP2K4 mitogen-activated protein kinase kinase 4
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAX MYC associated factor X
MVD mevalonate (diphospho) decarboxylase
N4BP1 NEDD4 binding protein 1
NDNF neuron-derived neurotrophic factor
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRP1 neuropilin 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PEX1 peroxisomal biogenesis factor 1
PICK1 protein interacting with PRKCA 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBM19 RNA binding motif protein 19
RBM48 RNA binding motif protein 48
RDX radixin
RGS14 regulator of G-protein signaling 14
RHOD ras homolog family member D
RNF167 ring finger protein 167
RNF6 ring finger protein (C3H2C3 type) 6
RUSC2 RUN and SH3 domain containing 2
S100A12 S100 calcium binding protein A12
SCGB2A2 secretoglobin, family 2A, member 2
SHB Src homology 2 domain containing adaptor protein B
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35E2 solute carrier family 35, member E2
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNW1 SNW domain containing 1
SOAT1 sterol O-acyltransferase 1
SRSF1 serine/arginine-rich splicing factor 1
SSBP3 single stranded DNA binding protein 3
STK38L serine/threonine kinase 38 like
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TM4SF5 transmembrane 4 L six family member 5
TMOD1 tropomodulin 1
TOP3A topoisomerase (DNA) III alpha
TRA T cell receptor alpha locus
TRD T cell receptor delta locus
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VILL villin-like
VIPR2 vasoactive intestinal peptide receptor 2
WAPAL wings apart-like homolog (Drosophila)
ZC3H13 zinc finger CCCH-type containing 13
ZNF467 zinc finger protein 467
ZNF609 zinc finger protein 609
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ACO1 aconitase 1, soluble
AGBL5 ATP/GTP binding protein-like 5
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP4 Rho GTPase activating protein 4
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARID5A AT rich interactive domain 5A (MRF1-like)
ARRB1 arrestin, beta 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATXN2 ataxin 2
BAMBI BMP and activin membrane-bound inhibitor
BBS1 Bardet-Biedl syndrome 1
C11ORF21 chromosome 11 open reading frame 21
C1ORF56 chromosome 1 open reading frame 56
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5ORF30 chromosome 5 open reading frame 30
CAMTA2 calmodulin binding transcription activator 2
CCDC109B coiled-coil domain containing 109B
CD82 CD82 molecule
CGREF1 cell growth regulator with EF-hand domain 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDN15 claudin 15
CUL9 cullin 9
CXORF56 chromosome X open reading frame 56
DBF4B DBF4 zinc finger B
DSE dermatan sulfate epimerase
DYM dymeclin
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV4 ets variant 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM127A family with sequence similarity 127, member A
FANCE Fanconi anemia, complementation group E
FKBP14 FK506 binding protein 14, 22 kDa
FKBPL FK506 binding protein like
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GIMAP6 GTPase, IMAP family member 6
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HIST1H2BI histone cluster 1, H2bi
HOXA1 homeobox A1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KCNK5 potassium channel, two pore domain subfamily K, member 5
LINC00339 long intergenic non-protein coding RNA 339
MAST3 microtubule associated serine/threonine kinase 3
MKS1 Meckel syndrome, type 1
MREG melanoregulin
MUM1 melanoma associated antigen (mutated) 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NHEJ1 nonhomologous end-joining factor 1
NOTCH1 notch 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NT5DC3 5'-nucleotidase domain containing 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PLA2G12A phospholipase A2, group XIIA
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PROS1 protein S (alpha)
RABL6 RAB, member RAS oncogene family-like 6
RANGRF RAN guanine nucleotide release factor
RHOBTB1 Rho-related BTB domain containing 1
RPL13P5 ribosomal protein L13 pseudogene 5
SERTAD3 SERTA domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX15 sorting nexin 15
SPAG1 sperm associated antigen 1
SPATA2L spermatogenesis associated 2-like
SPC25 SPC25, NDC80 kinetochore complex component
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TBP TATA box binding protein
TGFBR3 transforming growth factor, beta receptor III
TKFC triokinase/FMN cyclase
TLN1 talin 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TMEM184B transmembrane protein 184B
TMOD3 tropomodulin 3 (ubiquitous)
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM66 tripartite motif containing 66
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TTLL12 tubulin tyrosine ligase-like family member 12
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
UEVLD UEV and lactate/malate dehyrogenase domains
UNC93B1 unc-93 homolog B1 (C. elegans)
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZBTB10 zinc finger and BTB domain containing 10
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF253 zinc finger protein 253
ZNF408 zinc finger protein 408
ZNF623 zinc finger protein 623
ZNF816 zinc finger protein 816