alpha-estradiol-122 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-122 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACOT11 acyl-CoA thioesterase 11
ADAM12 ADAM metallopeptidase domain 12
AFF2 AF4/FMR2 family, member 2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AQP2 aquaporin 2 (collecting duct)
AQP3 aquaporin 3 (Gill blood group)
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASCL1 achaete-scute family bHLH transcription factor 1
BBC3 BCL2 binding component 3
BPHL biphenyl hydrolase-like (serine hydrolase)
BRAP BRCA1 associated protein
CA7 carbonic anhydrase VII
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPF centromere protein F, 350/400kDa
CEP68 centrosomal protein 68kDa
CLDN15 claudin 15
CTAGE5 CTAGE family, member 5
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGUOK deoxyguanosine kinase
DTNA dystrobrevin, alpha
DUS2 dihydrouridine synthase 2
E2F3 E2F transcription factor 3
EGR4 early growth response 4
EXOC7 exocyst complex component 7
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP2 FK506 binding protein 2, 13kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GOLGB1 golgin B1
GPX2 glutathione peroxidase 2
GRAMD1B GRAM domain containing 1B
GREB1L growth regulation by estrogen in breast cancer-like
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H3G histone cluster 1, H3g
HOXB1 homeobox B1
HR hair growth associated
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLK8 kallikrein-related peptidase 8
KRT38 keratin 38, type I
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LDLR low density lipoprotein receptor
LOC729164 hCG1732469
MAP4 microtubule-associated protein 4
MRPS15 mitochondrial ribosomal protein S15
MT1HL1 metallothionein 1H-like 1
MT3 metallothionein 3
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO9B myosin IXB
NIPAL2 NIPA-like domain containing 2
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEX10 peroxisomal biogenesis factor 10
PF4 platelet factor 4
PHF7 PHD finger protein 7
PIGR polymeric immunoglobulin receptor
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK3 polo-like kinase 3
PRB1 proline-rich protein BstNI subfamily 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PRRC2A proline-rich coiled-coil 2A
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RIPPLY3 ripply transcriptional repressor 3
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAG S-antigen; retina and pineal gland (arrestin)
SEZ6L seizure related 6 homolog (mouse)-like
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC41A3 solute carrier family 41, member 3
SOCS3 suppressor of cytokine signaling 3
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAB1 stabilin 1
STK19 serine/threonine kinase 19
STRA6 stimulated by retinoic acid 6
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLN2 talin 2
TMEM104 transmembrane protein 104
TMEM176A transmembrane protein 176A
TPMT thiopurine S-methyltransferase
TRNAU1AP tRNA selenocysteine 1 associated protein 1
TSN translin
UTRN utrophin
ZBTB22 zinc finger and BTB domain containing 22
ZER1 zyg-11 related, cell cycle regulator
ZNF562 zinc finger protein 562
ZNF609 zinc finger protein 609
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADGRG6 adhesion G protein-coupled receptor G6
AIDA axin interactor, dorsalization associated
ARHGAP10 Rho GTPase activating protein 10
ARMC4 armadillo repeat containing 4
ATXN2 ataxin 2
BACE1 beta-site APP-cleaving enzyme 1
C16ORF62 chromosome 16 open reading frame 62
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCDC6 coiled-coil domain containing 6
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEP192 centrosomal protein 192kDa
CHGB chromogranin B
CIC capicua transcriptional repressor
CLCF1 cardiotrophin-like cytokine factor 1
CRBN cereblon
DAGLA diacylglycerol lipase, alpha
DAO D-amino-acid oxidase
DENND6B DENN/MADD domain containing 6B
DHDDS dehydrodolichyl diphosphate synthase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DVL1 dishevelled segment polarity protein 1
ELMO3 engulfment and cell motility 3
EXOSC10 exosome component 10
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM50B family with sequence similarity 50, member B
FBXO31 F-box protein 31
FBXO46 F-box protein 46
FGF6 fibroblast growth factor 6
FSD1 fibronectin type III and SPRY domain containing 1
FUBP3 far upstream element (FUSE) binding protein 3
GDF3 growth differentiation factor 3
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GOLM1 golgi membrane protein 1
GPR21 G protein-coupled receptor 21
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRPR gastrin-releasing peptide receptor
GUCA1B guanylate cyclase activator 1B (retina)
HMGB3P1 high mobility group box 3 pseudogene 1
HOXA5 homeobox A5
HOXB2 homeobox B2
IL15RA interleukin 15 receptor, alpha
INTS8 integrator complex subunit 8
IRX4 iroquois homeobox 4
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KLHL25 kelch-like family member 25
LEFTY1 left-right determination factor 1
LGMN legumain
MIR22HG MIR22 host gene
MXI1 MAX interactor 1, dimerization protein
NBAS neuroblastoma amplified sequence
NFE2L2 nuclear factor, erythroid 2-like 2
NHEJ1 nonhomologous end-joining factor 1
NSD1 nuclear receptor binding SET domain protein 1
OVOL1 ovo-like zinc finger 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCNP PEST proteolytic signal containing nuclear protein
PELP1 proline, glutamate and leucine rich protein 1
PGP phosphoglycolate phosphatase
PLK1 polo-like kinase 1
PRPF38B pre-mRNA processing factor 38B
PRPH peripherin
QDPR quinoid dihydropteridine reductase
RAD54L RAD54-like (S. cerevisiae)
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RIPK4 receptor-interacting serine-threonine kinase 4
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPL11 ribosomal protein L11
SCD5 stearoyl-CoA desaturase 5
SEC24B SEC24 family member B
SERINC5 serine incorporator 5
SH2D4A SH2 domain containing 4A
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35E3 solute carrier family 35, member E3
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SNAI2 snail family zinc finger 2
SPDL1 spindle apparatus coiled-coil protein 1
SPIDR scaffolding protein involved in DNA repair
ST5 suppression of tumorigenicity 5
TAC3 tachykinin 3
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TCTN1 tectonic family member 1
TFCP2L1 transcription factor CP2-like 1
TGFBR1 transforming growth factor, beta receptor 1
TIPRL TOR signaling pathway regulator
TOPBP1 topoisomerase (DNA) II binding protein 1
TRAF5 TNF receptor-associated factor 5
TSC22D1 TSC22 domain family, member 1
TSPAN32 tetraspanin 32
TTC4 tetratricopeptide repeat domain 4
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR13 WD repeat domain 13
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YIPF5 Yip1 domain family, member 5
ZNF217 zinc finger protein 217
ZSCAN5A zinc finger and SCAN domain containing 5A