alpha-estradiol-1635 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-1635 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADRBK1 adrenergic, beta, receptor kinase 1
AFAP1 actin filament associated protein 1
ALS2CL ALS2 C-terminal like
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C1ORF106 chromosome 1 open reading frame 106
C21ORF2 chromosome 21 open reading frame 2
C2ORF27A chromosome 2 open reading frame 27A
CACYBP calcyclin binding protein
CCDC25 coiled-coil domain containing 25
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEMIP cell migration inducing protein, hyaluronan binding
CHKB choline kinase beta
CSF1 colony stimulating factor 1 (macrophage)
CTAGE5 CTAGE family, member 5
CXCR4 chemokine (C-X-C motif) receptor 4
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DND1 DND microRNA-mediated repression inhibitor 1
E2F4 E2F transcription factor 4, p107/p130-binding
EGFL7 EGF-like-domain, multiple 7
EGR3 early growth response 3
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FCMR Fc fragment of IgM receptor
FSCN1 fascin actin-bundling protein 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HOMER3 homer scaffolding protein 3
HSPA1L heat shock 70kDa protein 1-like
ICOSLG inducible T-cell co-stimulator ligand
IL11 interleukin 11
IRF5 interferon regulatory factor 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KDM4C lysine (K)-specific demethylase 4C
KDM7A lysine (K)-specific demethylase 7A
KIF13B kinesin family member 13B
LHX6 LIM homeobox 6
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMBR1L limb development membrane protein 1-like
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MED28 mediator complex subunit 28
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPY1R neuropeptide Y receptor Y1
NTF3 neurotrophin 3
PARVA parvin, alpha
PCDHA6 protocadherin alpha 6
PGR progesterone receptor
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POFUT1 protein O-fucosyltransferase 1
POLL polymerase (DNA directed), lambda
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRLR prolactin receptor
PROS1 protein S (alpha)
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RELN reelin
RHOQ ras homolog family member Q
RIMS3 regulating synaptic membrane exocytosis 3
RNF19B ring finger protein 19B
RNF2 ring finger protein 2
RUNX1 runt-related transcription factor 1
SAYSD1 SAYSVFN motif domain containing 1
SEC24A SEC24 family member A
SIK3 SIK family kinase 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPHK2 sphingosine kinase 2
SYBU syntabulin (syntaxin-interacting)
TGFA transforming growth factor, alpha
TMEM164 transmembrane protein 164
TMPRSS3 transmembrane protease, serine 3
TRIM2 tripartite motif containing 2
TRIP11 thyroid hormone receptor interactor 11
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP34 ubiquitin specific peptidase 34
VEGFA vascular endothelial growth factor A
VGF VGF nerve growth factor inducible
YY1 YY1 transcription factor
ZCCHC11 zinc finger, CCHC domain containing 11
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF136 zinc finger protein 136
ZNF202 zinc finger protein 202
ZNF592 zinc finger protein 592
ZNF609 zinc finger protein 609
ZSCAN12 zinc finger and SCAN domain containing 12

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANP32A-IT1 ANP32A intronic transcript 1
ARMCX1 armadillo repeat containing, X-linked 1
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
C4ORF29 chromosome 4 open reading frame 29
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPN15 calpain 15
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK5 cyclin-dependent kinase 5
CDKL3 cyclin-dependent kinase-like 3
CHMP7 charged multivesicular body protein 7
CLCF1 cardiotrophin-like cytokine factor 1
CLDN9 claudin 9
CLSPN claspin
CTC1 CTS telomere maintenance complex component 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DENND4C DENN/MADD domain containing 4C
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM118A family with sequence similarity 118, member A
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBP2 guanylate binding protein 2, interferon-inducible
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLI3 GLI family zinc finger 3
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRAMD4 GRAM domain containing 4
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITPKB inositol-trisphosphate 3-kinase B
KDM5C lysine (K)-specific demethylase 5C
KIZ kizuna centrosomal protein
KLHL36 kelch-like family member 36
LINC00115 long intergenic non-protein coding RNA 115
LINC00339 long intergenic non-protein coding RNA 339
LRP3 low density lipoprotein receptor-related protein 3
LRRC8E leucine rich repeat containing 8 family, member E
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1S microtubule-associated protein 1S
MAP9 microtubule-associated protein 9
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBTD1 mbt domain containing 1
MED9 mediator complex subunit 9
MOCS3 molybdenum cofactor synthesis 3
MRPL52 mitochondrial ribosomal protein L52
MT1HL1 metallothionein 1H-like 1
MTRF1 mitochondrial translational release factor 1
NMU neuromedin U
NPFFR1 neuropeptide FF receptor 1
PCDHB3 protocadherin beta 3
PECR peroxisomal trans-2-enoyl-CoA reductase
POLH polymerase (DNA directed), eta
POTEKP POTE ankyrin domain family, member K, pseudogene
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRSS22 protease, serine, 22
PTCD2 pentatricopeptide repeat domain 2
PTK6 protein tyrosine kinase 6
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RIPK4 receptor-interacting serine-threonine kinase 4
RUFY2 RUN and FYVE domain containing 2
RWDD3 RWD domain containing 3
SCAMP4 secretory carrier membrane protein 4
SETD8 SET domain containing (lysine methyltransferase) 8
SHPK sedoheptulokinase
SIDT1 SID1 transmembrane family, member 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SPAST spastin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFBI transforming growth factor, beta-induced, 68kDa
THEM6 thioesterase superfamily member 6
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC13 trafficking protein particle complex 13
TRIM16 tripartite motif containing 16
UBQLN4 ubiquilin 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UNKL unkempt family zinc finger-like
VEGFC vascular endothelial growth factor C
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB25 zinc finger and BTB domain containing 25
ZNF250 zinc finger protein 250
ZNF394 zinc finger protein 394
ZNF430 zinc finger protein 430
ZNF652 zinc finger protein 652
ZNF665 zinc finger protein 665
ZNF710 zinc finger protein 710
ZXDC ZXD family zinc finger C