alpha-estradiol-2670 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the alpha-estradiol-2670 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAM8 ADAM metallopeptidase domain 8
AFF4 AF4/FMR2 family, member 4
AQP9 aquaporin 9
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASPH aspartate beta-hydroxylase
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTBD7 BTB (POZ) domain containing 7
BTF3P11 basic transcription factor 3 pseudogene 11
C2ORF54 chromosome 2 open reading frame 54
C9ORF9 chromosome 9 open reading frame 9
CALD1 caldesmon 1
CCL13 chemokine (C-C motif) ligand 13
CD248 CD248 molecule, endosialin
CDC14A cell division cycle 14A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP152 centrosomal protein 152kDa
CPA4 carboxypeptidase A4
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCAF15 DDB1 and CUL4 associated factor 15
DDR1 discoidin domain receptor tyrosine kinase 1
DMP1 dentin matrix acidic phosphoprotein 1
DTNB dystrobrevin, beta
EDN3 endothelin 3
EDNRB endothelin receptor type B
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EXT1 exostosin glycosyltransferase 1
FAM189A1 family with sequence similarity 189, member A1
FDXR ferredoxin reductase
FOXO4 forkhead box O4
GLRA1 glycine receptor, alpha 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GOLGA8A golgin A8 family, member A
GSPT1 G1 to S phase transition 1
GTPBP10 GTP-binding protein 10 (putative)
HOXD10 homeobox D10
ICAM5 intercellular adhesion molecule 5, telencephalin
IFNA10 interferon, alpha 10
IGHD immunoglobulin heavy constant delta
JRK Jrk homolog (mouse)
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KLF6 Kruppel-like factor 6
KLHL25 kelch-like family member 25
LAD1 ladinin 1
LRRC3 leucine rich repeat containing 3
MAOA monoamine oxidase A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MOXD1 monooxygenase, DBH-like 1
MUC6 mucin 6, oligomeric mucus/gel-forming
MYH4 myosin, heavy chain 4, skeletal muscle
NCAM1 neural cell adhesion molecule 1
NDN necdin, melanoma antigen (MAGE) family member
NOTCH4 notch 4
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OTOR otoraplin
PLCE1 phospholipase C, epsilon 1
PLVAP plasmalemma vesicle associated protein
PPARA peroxisome proliferator-activated receptor alpha
PRDM14 PR domain containing 14
PROL1 proline rich, lacrimal 1
PRSS8 protease, serine, 8
PSG4 pregnancy specific beta-1-glycoprotein 4
PTCH2 patched 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAP2B RAP2B, member of RAS oncogene family
RBP4 retinol binding protein 4, plasma
RERE arginine-glutamic acid dipeptide (RE) repeats
RFPL3S RFPL3 antisense
RGS12 regulator of G-protein signaling 12
RHBG Rh family, B glycoprotein (gene/pseudogene)
RUNX1 runt-related transcription factor 1
SCAND2P SCAN domain containing 2 pseudogene
SCRT1 scratch family zinc finger 1
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SEZ6L seizure related 6 homolog (mouse)-like
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A4 solute carrier family 17, member 4
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SPRR2B small proline-rich protein 2B
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYT13 synaptotagmin XIII
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TLR5 toll-like receptor 5
TP73-AS1 TP73 antisense RNA 1
TRAPPC9 trafficking protein particle complex 9
TRIM25 tripartite motif containing 25
TRIP11 thyroid hormone receptor interactor 11
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
XCL1 chemokine (C motif) ligand 1

decreased expression

Symbol Name
ADGB androglobin
AEN apoptosis enhancing nuclease
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARG1 arginase 1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
C19ORF40 chromosome 19 open reading frame 40
C22ORF29 chromosome 22 open reading frame 29
CAPN1 calpain 1, (mu/I) large subunit
CDK20 cyclin-dependent kinase 20
CEP97 centrosomal protein 97kDa
CHMP7 charged multivesicular body protein 7
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLIP2 CAP-GLY domain containing linker protein 2
CTSD cathepsin D
DNAL4 dynein, axonemal, light chain 4
EYA3 EYA transcriptional coactivator and phosphatase 3
GALE UDP-galactose-4-epimerase
GALT galactose-1-phosphate uridylyltransferase
GATA6 GATA binding protein 6
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR3 G protein-coupled receptor 3
GSDMD gasdermin D
HIST1H1E histone cluster 1, H1e
HOXA5 homeobox A5
HRH2 histamine receptor H2
JADE3 jade family PHD finger 3
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLF2 Kruppel-like factor 2
KLF3 Kruppel-like factor 3 (basic)
KPTN kaptin (actin binding protein)
KRT81 keratin 81, type II
LIN7B lin-7 homolog B (C. elegans)
LPPR3 lipid phosphate phosphatase-related protein type 3
MAGEF1 melanoma antigen family F1
MAP1S microtubule-associated protein 1S
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK12 mitogen-activated protein kinase 12
MBD5 methyl-CpG binding domain protein 5
MEGF8 multiple EGF-like-domains 8
MFSD11 major facilitator superfamily domain containing 11
MLPH melanophilin
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKX3-2 NK3 homeobox 2
NPFFR1 neuropeptide FF receptor 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCBP4 poly(rC) binding protein 4
PECR peroxisomal trans-2-enoyl-CoA reductase
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PIPOX pipecolic acid oxidase
PLAT plasminogen activator, tissue
POLM polymerase (DNA directed), mu
POMZP3 POM121 and ZP3 fusion
RAB13 RAB13, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN1 Ras and Rab interactor 1
RIN2 Ras and Rab interactor 2
RNF122 ring finger protein 122
RPL23AP7 ribosomal protein L23a pseudogene 7
RRAS related RAS viral (r-ras) oncogene homolog
S1PR4 sphingosine-1-phosphate receptor 4
SCAP SREBF chaperone
SERINC5 serine incorporator 5
SETD1A SET domain containing 1A
SHPK sedoheptulokinase
SLC10A3 solute carrier family 10, member 3
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLC16A4 solute carrier family 16, member 4
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPAG4 sperm associated antigen 4
SPRYD7 SPRY domain containing 7
STAT5A signal transducer and activator of transcription 5A
STBD1 starch binding domain 1
TAGLN transgelin
TAS2R10 taste receptor, type 2, member 10
TMC5 transmembrane channel-like 5
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOM1 target of myb1 (chicken)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
TUFT1 tuftelin 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WT1-AS WT1 antisense RNA
YY2 YY2 transcription factor
ZNF155 zinc finger protein 155
ZNF219 zinc finger protein 219
ZNF552 zinc finger protein 552
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768
ZNHIT2 zinc finger, HIT-type containing 2