alpha-estradiol-403 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-403 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AJAP1 adherens junctions associated protein 1
AQP3 aquaporin 3 (Gill blood group)
ART3 ADP-ribosyltransferase 3
ASTE1 asteroid homolog 1 (Drosophila)
BCAS1 breast carcinoma amplified sequence 1
C1ORF61 chromosome 1 open reading frame 61
C7ORF43 chromosome 7 open reading frame 43
CA6 carbonic anhydrase VI
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD38 CD38 molecule
CD5 CD5 molecule
CD6 CD6 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CFAP70 cilia and flagella associated protein 70
CFB complement factor B
CHD2 chromodomain helicase DNA binding protein 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
COX5B cytochrome c oxidase subunit Vb
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEFA4 defensin, alpha 4, corticostatin
DGKA diacylglycerol kinase, alpha 80kDa
DHRS9 dehydrogenase/reductase (SDR family) member 9
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ESR2 estrogen receptor 2 (ER beta)
FGL1 fibrinogen-like 1
FOSL2 FOS-like antigen 2
GPR15 G protein-coupled receptor 15
GRPR gastrin-releasing peptide receptor
HAP1 huntingtin-associated protein 1
HMGA1 high mobility group AT-hook 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFNA4 interferon, alpha 4
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL15RA interleukin 15 receptor, alpha
IL2RG interleukin 2 receptor, gamma
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
IVL involucrin
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KLHL28 kelch-like family member 28
LIM2 lens intrinsic membrane protein 2, 19kDa
LIMS2 LIM and senescent cell antigen-like domains 2
LIN7B lin-7 homolog B (C. elegans)
LINC01558 long intergenic non-protein coding RNA 1558
LMO3 LIM domain only 3 (rhombotin-like 2)
LMTK2 lemur tyrosine kinase 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP6 low density lipoprotein receptor-related protein 6
LUZP4 leucine zipper protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MC5R melanocortin 5 receptor
MINK1 misshapen-like kinase 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYOZ3 myozenin 3
NAP1L1 nucleosome assembly protein 1-like 1
NDRG2 NDRG family member 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUP160 nucleoporin 160kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDE12 phosphodiesterase 12
PHOX2A paired-like homeobox 2a
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPP1R10 protein phosphatase 1, regulatory subunit 10
PQLC3 PQ loop repeat containing 3
PROP1 PROP paired-like homeobox 1
PSAT1 phosphoserine aminotransferase 1
PSG11 pregnancy specific beta-1-glycoprotein 11
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRT protein tyrosine phosphatase, receptor type, T
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARG retinoic acid receptor, gamma
RCAN1 regulator of calcineurin 1
SAG S-antigen; retina and pineal gland (arrestin)
SDC3 syndecan 3
SH3D21 SH3 domain containing 21
SIGLEC9 sialic acid binding Ig-like lectin 9
SLAMF8 SLAM family member 8
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC45A2 solute carrier family 45, member 2
SYNDIG1 synapse differentiation inducing 1
TMEM2 transmembrane protein 2
TMEM63A transmembrane protein 63A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPSAB1 tryptase alpha/beta 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPY1 testis specific protein, Y-linked 1
USF2 upstream transcription factor 2, c-fos interacting
ZNF460 zinc finger protein 460

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACTC1 actin, alpha, cardiac muscle 1
ACVR1 activin A receptor, type I
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGAP5 Rho GTPase activating protein 5
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARPIN actin-related protein 2/3 complex inhibitor
BIK BCL2-interacting killer (apoptosis-inducing)
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CBX7 chromobox homolog 7
CDK3 cyclin-dependent kinase 3
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDN17 claudin 17
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CPOX coproporphyrinogen oxidase
CRABP1 cellular retinoic acid binding protein 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CROT carnitine O-octanoyltransferase
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYB5R2 cytochrome b5 reductase 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAAF2 dynein, axonemal, assembly factor 2
DOK3 docking protein 3
DUSP8 dual specificity phosphatase 8
EAF2 ELL associated factor 2
EFNA1 ephrin-A1
EPHA4 EPH receptor A4
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOXD1 forkhead box D1
FSD1 fibronectin type III and SPRY domain containing 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GDF3 growth differentiation factor 3
GLMN glomulin, FKBP associated protein
GMIP GEM interacting protein
GPN3 GPN-loop GTPase 3
GRAMD3 GRAM domain containing 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2AM histone cluster 1, H2am
HMHA1 histocompatibility (minor) HA-1
IL25 interleukin 25
KCTD9 potassium channel tetramerization domain containing 9
KIF20B kinesin family member 20B
LIAS lipoic acid synthetase
LINC00574 long intergenic non-protein coding RNA 574
LOC440895 two pore channel 3 pseudogene
MAGOHB mago-nashi homolog B (Drosophila)
MTMR10 myotubularin related protein 10
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NXPH3 neurexophilin 3
OGFRL1 opioid growth factor receptor-like 1
PCDHB3 protocadherin beta 3
PCTP phosphatidylcholine transfer protein
PEMT phosphatidylethanolamine N-methyltransferase
PISD phosphatidylserine decarboxylase
PNRC1 proline-rich nuclear receptor coactivator 1
PODNL1 podocan-like 1
PRR7 proline rich 7 (synaptic)
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPS17P5 ribosomal protein S17 pseudogene 5
S100PBP S100P binding protein
SCAF8 SR-related CTD-associated factor 8
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SMYD5 SMYD family member 5
SNX24 sorting nexin 24
SOX21 SRY (sex determining region Y)-box 21
SPAG4 sperm associated antigen 4
T T, brachyury homolog (mouse)
TCEA2 transcription elongation factor A (SII), 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TJP2 tight junction protein 2
TP53BP1 tumor protein p53 binding protein 1
TRAF2 TNF receptor-associated factor 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
WDR13 WD repeat domain 13
WWC2 WW and C2 domain containing 2
XYLT2 xylosyltransferase II
ZHX2 zinc fingers and homeoboxes 2
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF184 zinc finger protein 184
ZNF446 zinc finger protein 446
ZXDC ZXD family zinc finger C