alpha-estradiol-4434 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the alpha-estradiol-4434 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C4 aldo-keto reductase family 1, member C4
AMACR alpha-methylacyl-CoA racemase
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOE apolipoprotein E
ARG1 arginase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP10A ATPase, class V, type 10A
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
BAAT bile acid CoA:amino acid N-acyltransferase
CADM3 cell adhesion molecule 3
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCDC57 coiled-coil domain containing 57
COL10A1 collagen, type X, alpha 1
COLEC10 collectin sub-family member 10 (C-type lectin)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL5 chemokine (C-X-C motif) ligand 5
CXORF21 chromosome X open reading frame 21
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DMC1 DNA meiotic recombinase 1
DMWD dystrophia myotonica, WD repeat containing
DTNA dystrobrevin, alpha
E2F2 E2F transcription factor 2
EML2 echinoderm microtubule associated protein like 2
EPHB1 EPH receptor B1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EYA3 EYA transcriptional coactivator and phosphatase 3
F13B coagulation factor XIII, B polypeptide
FAM134B family with sequence similarity 134, member B
FAM212B family with sequence similarity 212, member B
FAS Fas cell surface death receptor
FBXO40 F-box protein 40
FOXG1 forkhead box G1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR75 G protein-coupled receptor 75
GSTM5 glutathione S-transferase mu 5
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HAP1 huntingtin-associated protein 1
HFE hemochromatosis
HGD homogentisate 1,2-dioxygenase
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGHMBP2 immunoglobulin mu binding protein 2
IRF4 interferon regulatory factor 4
KERA keratocan
KIF1A kinesin family member 1A
KLHDC8A kelch domain containing 8A
KRT85 keratin 85, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LGALS8 lectin, galactoside-binding, soluble, 8
LIPE lipase, hormone-sensitive
LOC157562 uncharacterized LOC157562
LPAR4 lysophosphatidic acid receptor 4
MIP major intrinsic protein of lens fiber
MMP3 matrix metallopeptidase 3
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP2L1 NEDD4 binding protein 2-like 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
PAPOLA poly(A) polymerase alpha
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PGAP3 post-GPI attachment to proteins 3
PKNOX2 PBX/knotted 1 homeobox 2
POU6F1 POU class 6 homeobox 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SCAND2P SCAN domain containing 2 pseudogene
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SFRP4 secreted frizzled-related protein 4
SH3D21 SH3 domain containing 21
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SPRED2 sprouty-related, EVH1 domain containing 2
SPTBN5 spectrin, beta, non-erythrocytic 5
STAT2 signal transducer and activator of transcription 2, 113kDa
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TLX2 T-cell leukemia homeobox 2
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPP1 tripeptidyl peptidase I
TSPAN2 tetraspanin 2
ZFHX2 zinc finger homeobox 2
ZFPM2 zinc finger protein, FOG family member 2
ZKSCAN7 zinc finger with KRAB and SCAN domains 7
ZNF235 zinc finger protein 235
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ANKH ANKH inorganic pyrophosphate transport regulator
ANP32A-IT1 ANP32A intronic transcript 1
ANXA2P1 annexin A2 pseudogene 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C17ORF53 chromosome 17 open reading frame 53
C19ORF40 chromosome 19 open reading frame 40
C22ORF29 chromosome 22 open reading frame 29
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CCDC186 coiled-coil domain containing 186
CD82 CD82 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES3 carboxylesterase 3
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIDEC cell death-inducing DFFA-like effector c
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
COL9A3 collagen, type IX, alpha 3
CORT cortistatin
CXCL3 chemokine (C-X-C motif) ligand 3
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EPPK1 epiplakin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCE Fanconi anemia, complementation group E
FRMD1 FERM domain containing 1
GAS8 growth arrest-specific 8
GRTP1 growth hormone regulated TBC protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK1 hook microtubule-tethering protein 1
HOXB2 homeobox B2
IL12A interleukin 12A
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INO80D INO80 complex subunit D
ISL1 ISL LIM homeobox 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIRREL kin of IRRE like (Drosophila)
KLHL29 kelch-like family member 29
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LOC390998 ribosomal protein L10 pseudogene
LRRC6 leucine rich repeat containing 6
MILR1 mast cell immunoglobulin-like receptor 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXD3 MAX dimerization protein 3
MXRA8 matrix-remodelling associated 8
NAT6 N-acetyltransferase 6 (GCN5-related)
NCALD neurocalcin delta
NEUROD4 neuronal differentiation 4
NID2 nidogen 2 (osteonidogen)
NPY1R neuropeptide Y receptor Y1
NT5M 5',3'-nucleotidase, mitochondrial
PDE12 phosphodiesterase 12
PER3 period circadian clock 3
PGPEP1 pyroglutamyl-peptidase I
PHC1 polyhomeotic homolog 1 (Drosophila)
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLA1A phospholipase A1 member A
PLD2 phospholipase D2
PODXL2 podocalyxin-like 2
POMT2 protein-O-mannosyltransferase 2
POU3F2 POU class 3 homeobox 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RPA4 replication protein A4, 30kDa
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCAMP5 secretory carrier membrane protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMO smoothened, frizzled class receptor
SOSTDC1 sclerostin domain containing 1
STAG3 stromal antigen 3
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCEAL2 transcription elongation factor A (SII)-like 2
TEX40 testis expressed 40
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM120B transmembrane protein 120B
TMEM8B transmembrane protein 8B
TRPS1 trichorhinophalangeal syndrome I
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZNF276 zinc finger protein 276
ZNF528 zinc finger protein 528
ZNF76 zinc finger protein 76
ZNF778 zinc finger protein 778