alpha-estradiol-5207 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the alpha-estradiol-5207 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AIF1 allograft inflammatory factor 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARC activity-regulated cytoskeleton-associated protein
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATN1 atrophin 1
B9D2 B9 protein domain 2
BAIAP3 BAI1-associated protein 3
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL27 chemokine (C-C motif) ligand 27
CCNO cyclin O
CD52 CD52 molecule
CDK6 cyclin-dependent kinase 6
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CTSZ cathepsin Z
DMRT1 doublesex and mab-3 related transcription factor 1
EDA ectodysplasin A
EFNB3 ephrin-B3
EGR3 early growth response 3
EN2 engrailed homeobox 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHB1 EPH receptor B1
FCMR Fc fragment of IgM receptor
FGF16 fibroblast growth factor 16
FOXC1 forkhead box C1
FRAS1 Fraser extracellular matrix complex subunit 1
GAP43 growth associated protein 43
GATA4 GATA binding protein 4
GK3P glycerol kinase 3 pseudogene
HIPK2 homeodomain interacting protein kinase 2
HIST1H3F histone cluster 1, H3f
HOXC8 homeobox C8
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IGHM immunoglobulin heavy constant mu
JRK Jrk homolog (mouse)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRT15 keratin 15, type I
KSR1 kinase suppressor of ras 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOB monoamine oxidase B
MAPK8 mitogen-activated protein kinase 8
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD2 methyl-CpG binding domain protein 2
MC5R melanocortin 5 receptor
MCAM melanoma cell adhesion molecule
MCF2L MCF.2 cell line derived transforming sequence-like
MYCNOS MYCN opposite strand
N4BP2L1 NEDD4 binding protein 2-like 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NME5 NME/NM23 family member 5
NOL10 nucleolar protein 10
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
NR5A2 nuclear receptor subfamily 5, group A, member 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX1 PBX/knotted 1 homeobox 1
PLAC1 placenta-specific 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPP1R37 protein phosphatase 1, regulatory subunit 37
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS12 regulator of G-protein signaling 12
RLN1 relaxin 1
SDC3 syndecan 3
SH3D21 SH3 domain containing 21
SIDT2 SID1 transmembrane family, member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNRK SNF related kinase
SOX3 SRY (sex determining region Y)-box 3
SRSF5 serine/arginine-rich splicing factor 5
SSPN sarcospan
ST7L suppression of tumorigenicity 7 like
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCF3 transcription factor 3
TGM2 transglutaminase 2
TMC6 transmembrane channel-like 6
TP63 tumor protein p63
TPM2 tropomyosin 2 (beta)
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
TUBB2B tubulin, beta 2B class IIb
USP2 ubiquitin specific peptidase 2
WDR33 WD repeat domain 33
ZBTB22 zinc finger and BTB domain containing 22
ZFP64 ZFP64 zinc finger protein
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ABHD17B abhydrolase domain containing 17B
ADORA2B adenosine A2b receptor
ALS2CL ALS2 C-terminal like
ANP32A-IT1 ANP32A intronic transcript 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARRB1 arrestin, beta 1
ASAP1-IT1 ASAP1 intronic transcript 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
BCAS1 breast carcinoma amplified sequence 1
BHLHE41 basic helix-loop-helix family, member e41
C14ORF93 chromosome 14 open reading frame 93
C2ORF54 chromosome 2 open reading frame 54
CBX8 chromobox homolog 8
CCDC186 coiled-coil domain containing 186
CENPO centromere protein O
CHST10 carbohydrate sulfotransferase 10
CLDN15 claudin 15
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORO2A coronin, actin binding protein, 2A
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCP1A decapping mRNA 1A
DDIT3 DNA-damage-inducible transcript 3
EFNA3 ephrin-A3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
FAM169A family with sequence similarity 169, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXD1 forkhead box D1
FURIN furin (paired basic amino acid cleaving enzyme)
GAREM GRB2 associated, regulator of MAPK1
GPATCH3 G patch domain containing 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1E histone cluster 1, H1e
HIST1H2BJ histone cluster 1, H2bj
HOXC13 homeobox C13
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI2-AS1 IDI2 antisense RNA 1
IFT140 intraflagellar transport 140
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KAT2A K(lysine) acetyltransferase 2A
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLHL36 kelch-like family member 36
KPTN kaptin (actin binding protein)
KREMEN2 kringle containing transmembrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MOCS3 molybdenum cofactor synthesis 3
MON1B MON1 secretory trafficking family member B
MPDU1 mannose-P-dolichol utilization defect 1
MTERF4 mitochondrial transcription termination factor 4
MYO9A myosin IXA
N4BP3 NEDD4 binding protein 3
NHLRC2 NHL repeat containing 2
NOL12 nucleolar protein 12
NPIPB3 nuclear pore complex interacting protein family, member B3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAQR6 progestin and adipoQ receptor family member VI
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PNPLA6 patatin-like phospholipase domain containing 6
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PYCRL pyrroline-5-carboxylate reductase-like
QPCT glutaminyl-peptide cyclotransferase
QPCTL glutaminyl-peptide cyclotransferase-like
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC38A10 solute carrier family 38, member 10
SP1 Sp1 transcription factor
SP140L SP140 nuclear body protein-like
TBC1D17 TBC1 domain family, member 17
TCTN2 tectonic family member 2
TH tyrosine hydroxylase
THBS3 thrombospondin 3
TMEM212 transmembrane protein 212
TRDMT1 tRNA aspartic acid methyltransferase 1
TUBG2 tubulin, gamma 2
UBQLN4 ubiquilin 4
USP20 ubiquitin specific peptidase 20
ZC3H3 zinc finger CCCH-type containing 3
ZNF428 zinc finger protein 428
ZNF767P zinc finger family member 767, pseudogene
ZSCAN31 zinc finger and SCAN domain containing 31