alpha-estradiol-5570 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the alpha-estradiol-5570 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALS2CL ALS2 C-terminal like
AMELY amelogenin, Y-linked
AMPH amphiphysin
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA1 carbonic anhydrase I
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAV2 caveolin 2
CD177 CD177 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD48 CD48 molecule
CD83 CD83 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CIC capicua transcriptional repressor
CNTNAP2 contactin associated protein-like 2
COL1A1 collagen, type I, alpha 1
CSF1R colony stimulating factor 1 receptor
CT62 cancer/testis antigen 62
CTSZ cathepsin Z
CYHR1 cysteine/histidine-rich 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DISC1 disrupted in schizophrenia 1
DPF1 D4, zinc and double PHD fingers family 1
EDNRA endothelin receptor type A
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL2 ELOVL fatty acid elongase 2
EMP1 epithelial membrane protein 1
ETV7 ets variant 7
F13A1 coagulation factor XIII, A1 polypeptide
FAM46C family with sequence similarity 46, member C
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
GPR143 G protein-coupled receptor 143
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3A glycogen synthase kinase 3 alpha
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HIST1H2BN histone cluster 1, H2bn
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IFI6 interferon, alpha-inducible protein 6
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK2 potassium channel, two pore domain subfamily K, member 2
KLHL25 kelch-like family member 25
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LIN28A lin-28 homolog A (C. elegans)
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMO1 LIM domain only 1 (rhombotin 1)
MAOB monoamine oxidase B
MAPK14 mitogen-activated protein kinase 14
MCFD2 multiple coagulation factor deficiency 2
MFSD7 major facilitator superfamily domain containing 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC4 mucin 4, cell surface associated
MVP major vault protein
MYH14 myosin, heavy chain 14, non-muscle
NCKIPSD NCK interacting protein with SH3 domain
NKX6-1 NK6 homeobox 1
NLRP3 NLR family, pyrin domain containing 3
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
PPP1R37 protein phosphatase 1, regulatory subunit 37
PRDM14 PR domain containing 14
RAB40C RAB40C, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RBBP9 retinoblastoma binding protein 9
RBMS2 RNA binding motif, single stranded interacting protein 2
RORC RAR-related orphan receptor C
S100A8 S100 calcium binding protein A8
SAYSD1 SAYSVFN motif domain containing 1
SH3D21 SH3 domain containing 21
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SPINK5 serine peptidase inhibitor, Kazal type 5
TBXA2R thromboxane A2 receptor
TGFA transforming growth factor, alpha
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TP63 tumor protein p63
TPSAB1 tryptase alpha/beta 1
TRIM3 tripartite motif containing 3
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSC2 tuberous sclerosis 2
USP27X ubiquitin specific peptidase 27, X-linked
ZMAT4 zinc finger, matrin-type 4

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADTRP androgen-dependent TFPI-regulating protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARSB arylsulfatase B
B9D2 B9 protein domain 2
BHLHE41 basic helix-loop-helix family, member e41
C11ORF30 chromosome 11 open reading frame 30
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC132 coiled-coil domain containing 132
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD1A CD1a molecule
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CUL9 cullin 9
DSCAM Down syndrome cell adhesion molecule
ETV6 ets variant 6
EXD3 exonuclease 3'-5' domain containing 3
FADS2 fatty acid desaturase 2
FAM204A family with sequence similarity 204, member A
FGF6 fibroblast growth factor 6
FMO4 flavin containing monooxygenase 4
FZD4 frizzled class receptor 4
GAREM GRB2 associated, regulator of MAPK1
GLB1L galactosidase, beta 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HDAC5 histone deacetylase 5
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOXA4 homeobox A4
HOXB2 homeobox B2
IGFBP6 insulin-like growth factor binding protein 6
INPP1 inositol polyphosphate-1-phosphatase
IQCC IQ motif containing C
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIF13B kinesin family member 13B
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT15 keratin 15, type I
LPPR1 lipid phosphate phosphatase-related protein type 1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MATK megakaryocyte-associated tyrosine kinase
MDM4 MDM4, p53 regulator
MECR mitochondrial trans-2-enoyl-CoA reductase
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PAX9 paired box 9
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G3 phospholipase A2, group III
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLXNA3 plexin A3
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PRSS53 protease, serine, 53
RAB33B RAB33B, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCPEP1 serine carboxypeptidase 1
SDC3 syndecan 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD1B SET domain containing 1B
SGCE sarcoglycan, epsilon
SLC12A8 solute carrier family 12, member 8
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMIM14 small integral membrane protein 14
SRD5A3 steroid 5 alpha-reductase 3
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEX40 testis expressed 40
TOLLIP toll interacting protein
TRAIP TRAF interacting protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TWSG1 twisted gastrulation BMP signaling modulator 1
UPK2 uroplakin 2
VIM vimentin
XYLT1 xylosyltransferase I
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF16 zinc finger protein 16
ZNF276 zinc finger protein 276
ZNF442 zinc finger protein 442
ZNF446 zinc finger protein 446
ZNF623 zinc finger protein 623