alpha-estradiol-6169 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-6169 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACACB acetyl-CoA carboxylase beta
ACO2 aconitase 2, mitochondrial
ACTA1 actin, alpha 1, skeletal muscle
ADAM22 ADAM metallopeptidase domain 22
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AHSP alpha hemoglobin stabilizing protein
AK5 adenylate kinase 5
ANXA2P3 annexin A2 pseudogene 3
ASIC4 acid sensing (proton gated) ion channel family member 4
BTNL3 butyrophilin-like 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C17ORF59 chromosome 17 open reading frame 59
CADPS2 Ca++-dependent secretion activator 2
CAMP cathelicidin antimicrobial peptide
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC85B coiled-coil domain containing 85B
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CFAP70 cilia and flagella associated protein 70
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLTA clathrin, light chain A
CPLX2 complexin 2
CRP C-reactive protein, pentraxin-related
CUL7 cullin 7
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DSCAM Down syndrome cell adhesion molecule
DVL2 dishevelled segment polarity protein 2
EPS8L3 EPS8-like 3
ESR1 estrogen receptor 1
ETV7 ets variant 7
FAM189A1 family with sequence similarity 189, member A1
FBXL18 F-box and leucine-rich repeat protein 18
FBXO31 F-box protein 31
FGFR2 fibroblast growth factor receptor 2
GAP43 growth associated protein 43
GLYAT glycine-N-acyltransferase
GPC1 glypican 1
GPM6B glycoprotein M6B
GPR153 G protein-coupled receptor 153
GTPBP1 GTP binding protein 1
HFE hemochromatosis
HHLA1 HERV-H LTR-associating 1
HIST1H4E histone cluster 1, H4e
HNF1B HNF1 homeobox B
HOMER2 homer scaffolding protein 2
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IGFBP5 insulin-like growth factor binding protein 5
IQSEC1 IQ motif and Sec7 domain 1
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
ITM2A integral membrane protein 2A
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIF25 kinesin family member 25
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MC5R melanocortin 5 receptor
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLXIP MLX interacting protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MRC2 mannose receptor, C type 2
MTMR8 myotubularin related protein 8
MYBPC3 myosin binding protein C, cardiac
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NTS neurotensin
OLFM1 olfactomedin 1
OSBPL7 oxysterol binding protein-like 7
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDH17 protocadherin 17
PCDHGB5 protocadherin gamma subfamily B, 5
PCDHGC3 protocadherin gamma subfamily C, 3
PDE4D phosphodiesterase 4D, cAMP-specific
PIGR polymeric immunoglobulin receptor
PLXNA2 plexin A2
PRB4 proline-rich protein BstNI subfamily 4
PRKY protein kinase, Y-linked, pseudogene
PTCRA pre T-cell antigen receptor alpha
RAB3D RAB3D, member RAS oncogene family
RASAL2 RAS protein activator like 2
RPL10L ribosomal protein L10-like
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC16A4 solute carrier family 16, member 4
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SPAG4 sperm associated antigen 4
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SSX1 synovial sarcoma, X breakpoint 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBCD tubulin folding cofactor D
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRPA1 transient receptor potential cation channel, subfamily A, member 1
UBQLN4 ubiquilin 4
USP46 ubiquitin specific peptidase 46
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WNT16 wingless-type MMTV integration site family, member 16
ZBED2 zinc finger, BED-type containing 2
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ALPK1 alpha-kinase 1
ANO10 anoctamin 10
ARMC6 armadillo repeat containing 6
BAHD1 bromo adjacent homology domain containing 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTBD18 BTB (POZ) domain containing 18
C22ORF46 chromosome 22 open reading frame 46
C8ORF44 chromosome 8 open reading frame 44
CARM1 coactivator-associated arginine methyltransferase 1
CCL4 chemokine (C-C motif) ligand 4
CGRRF1 cell growth regulator with ring finger domain 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CRYL1 crystallin, lambda 1
CTSV cathepsin V
DOK3 docking protein 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFHC1 EF-hand domain (C-terminal) containing 1
EXD3 exonuclease 3'-5' domain containing 3
EXOC2 exocyst complex component 2
FAM172A family with sequence similarity 172, member A
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLCE glucuronic acid epimerase
GPATCH2 G patch domain containing 2
GPATCH2L G patch domain containing 2-like
GPR35 G protein-coupled receptor 35
HHLA3 HERV-H LTR-associating 3
HIST1H2AJ histone cluster 1, H2aj
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXA1 homeobox A1
IDI2-AS1 IDI2 antisense RNA 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ITGB7 integrin, beta 7
ITPKC inositol-trisphosphate 3-kinase C
KIAA0319L KIAA0319-like
KIAA0753 KIAA0753
KIAA1024 KIAA1024
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LHFP lipoma HMGIC fusion partner
LTC4S leukotriene C4 synthase
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MON1B MON1 secretory trafficking family member B
MTA2 metastasis associated 1 family, member 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO15A myosin XVA
NHEJ1 nonhomologous end-joining factor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPM3 nucleophosmin/nucleoplasmin 3
NT5M 5',3'-nucleotidase, mitochondrial
PDGFD platelet derived growth factor D
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POM121 POM121 transmembrane nucleoporin
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PTPRS protein tyrosine phosphatase, receptor type, S
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PYCRL pyrroline-5-carboxylate reductase-like
PYGB phosphorylase, glycogen; brain
R3HCC1L R3H domain and coiled-coil containing 1-like
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPAP1 RNA polymerase II associated protein 1
S1PR4 sphingosine-1-phosphate receptor 4
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD8 SET domain containing (lysine methyltransferase) 8
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SMYD5 SMYD family member 5
SPRYD7 SPRY domain containing 7
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN1 tectonic family member 1
TGM5 transglutaminase 5
TIMP2 TIMP metallopeptidase inhibitor 2
TPBG trophoblast glycoprotein
TPST1 tyrosylprotein sulfotransferase 1
TRIM5 tripartite motif containing 5
TRPS1 trichorhinophalangeal syndrome I
TUBA3C tubulin, alpha 3c
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR33 WD repeat domain 33
WDR91 WD repeat domain 91
ZBED1 zinc finger, BED-type containing 1
ZC4H2 zinc finger, C4H2 domain containing
ZNF134 zinc finger protein 134
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF506 zinc finger protein 506
ZNF668 zinc finger protein 668