alpha-estradiol-6970 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-6970 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD17B abhydrolase domain containing 17B
ADRA1D adrenoceptor alpha 1D
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APOC1 apolipoprotein C-I
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
AURKA aurora kinase A
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BCL2 B-cell CLL/lymphoma 2
C14ORF79 chromosome 14 open reading frame 79
CA9 carbonic anhydrase IX
CARD9 caspase recruitment domain family, member 9
CD47 CD47 molecule
CHRM3 cholinergic receptor, muscarinic 3
CLDN17 claudin 17
CLU clusterin
CRISP2 cysteine-rich secretory protein 2
CTNS cystinosin, lysosomal cystine transporter
DAPK2 death-associated protein kinase 2
DBN1 drebrin 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DSTYK dual serine/threonine and tyrosine protein kinase
EDA ectodysplasin A
EGFL7 EGF-like-domain, multiple 7
EGR3 early growth response 3
EPOR erythropoietin receptor
ESR1 estrogen receptor 1
ETV6 ets variant 6
FAM131A family with sequence similarity 131, member A
FGL1 fibrinogen-like 1
FLT4 fms-related tyrosine kinase 4
GK glycerol kinase
GLP1R glucagon-like peptide 1 receptor
GLS glutaminase
GM2A GM2 ganglioside activator
GTDC1 glycosyltransferase-like domain containing 1
HCFC1 host cell factor C1
HCG4 HLA complex group 4 (non-protein coding)
HSPA1L heat shock 70kDa protein 1-like
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IDS iduronate 2-sulfatase
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL11 interleukin 11
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITM2C integral membrane protein 2C
ITPKB inositol-trisphosphate 3-kinase B
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KLHL22 kelch-like family member 22
KRT19P2 keratin 19 pseudogene 2
KRT24 keratin 24, type I
LMBR1L limb development membrane protein 1-like
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPT microtubule-associated protein tau
MAST3 microtubule associated serine/threonine kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MED12 mediator complex subunit 12
MYO10 myosin X
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCBP1 nuclear cap binding protein subunit 1, 80kDa
PGBD5 piggyBac transposable element derived 5
PHF20 PHD finger protein 20
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRSS16 protease, serine, 16 (thymus)
PTRF polymerase I and transcript release factor
RBM12 RNA binding motif protein 12
RIN1 Ras and Rab interactor 1
RS1 retinoschisin 1
RYR2 ryanodine receptor 2 (cardiac)
S100A7 S100 calcium binding protein A7
SBF1 SET binding factor 1
SH3BP2 SH3-domain binding protein 2
SIDT2 SID1 transmembrane family, member 2
SLC25A30 solute carrier family 25, member 30
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SORT1 sortilin 1
SPG20 spastic paraplegia 20 (Troyer syndrome)
ST7 suppression of tumorigenicity 7
TGM2 transglutaminase 2
TK2 thymidine kinase 2, mitochondrial
TPM1 tropomyosin 1 (alpha)
TTC28 tetratricopeptide repeat domain 28
TUBA3D tubulin, alpha 3d
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VEGFA vascular endothelial growth factor A
WDR76 WD repeat domain 76
WFDC2 WAP four-disulfide core domain 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XK X-linked Kx blood group
ZNF362 zinc finger protein 362
ZNF473 zinc finger protein 473
ZNF609 zinc finger protein 609
ZNF711 zinc finger protein 711
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACVR2B activin A receptor, type IIB
ADCK3 aarF domain containing kinase 3
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AMPD2 adenosine monophosphate deaminase 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
AOX1 aldehyde oxidase 1
ATAD3A ATPase family, AAA domain containing 3A
B3GAT3 beta-1,3-glucuronyltransferase 3
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C1ORF109 chromosome 1 open reading frame 109
C1ORF115 chromosome 1 open reading frame 115
C3ORF52 chromosome 3 open reading frame 52
C5 complement component 5
CAMTA2 calmodulin binding transcription activator 2
CCDC6 coiled-coil domain containing 6
CCNT1 cyclin T1
CENPJ centromere protein J
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSPN claspin
CORO1A coronin, actin binding protein, 1A
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSTA cystatin A (stefin A)
CTC1 CTS telomere maintenance complex component 1
DDIT3 DNA-damage-inducible transcript 3
DNAL4 dynein, axonemal, light chain 4
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECHDC3 enoyl CoA hydratase domain containing 3
EFNA1 ephrin-A1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ERI3 ERI1 exoribonuclease family member 3
ETAA1 Ewing tumor-associated antigen 1
EVPL envoplakin
FAM86C1 family with sequence similarity 86, member C1
FBXO31 F-box protein 31
FMO4 flavin containing monooxygenase 4
FOXK2 forkhead box K2
GLCE glucuronic acid epimerase
GLTSCR1 glioma tumor suppressor candidate region gene 1
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HAUS2 HAUS augmin-like complex, subunit 2
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H2AM histone cluster 1, H2am
HOXC13 homeobox C13
IFT81 intraflagellar transport 81
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
JADE3 jade family PHD finger 3
KAT2B K(lysine) acetyltransferase 2B
L2HGDH L-2-hydroxyglutarate dehydrogenase
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYPD3 LY6/PLAUR domain containing 3
MAPK12 mitogen-activated protein kinase 12
METTL21B methyltransferase like 21B
MRPL2 mitochondrial ribosomal protein L2
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MUM1 melanoma associated antigen (mutated) 1
MYO1E myosin IE
NES nestin
NOTCH1 notch 1
NRGN neurogranin (protein kinase C substrate, RC3)
PARD6A par-6 family cell polarity regulator alpha
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PCTP phosphatidylcholine transfer protein
PGP phosphoglycolate phosphatase
RFX7 regulatory factor X, 7
RIBC2 RIB43A domain with coiled-coils 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
S100A4 S100 calcium binding protein A4
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2B3 SH2B adaptor protein 3
SH3GL1 SH3-domain GRB2-like 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC12A9 solute carrier family 12, member 9
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNIP1 Smad nuclear interacting protein 1
SOWAHC sosondowah ankyrin repeat domain family member C
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNGR3 synaptogyrin 3
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TCTA T-cell leukemia translocation altered
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIP10 thyroid hormone receptor interactor 10
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UNC119 unc-119 homolog (C. elegans)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR60 WD repeat domain 60
YEATS2 YEATS domain containing 2
ZBTB10 zinc finger and BTB domain containing 10
ZBTB25 zinc finger and BTB domain containing 25
ZNF253 zinc finger protein 253
ZNF282 zinc finger protein 282
ZNF432 zinc finger protein 432
ZNF668 zinc finger protein 668