alpha-estradiol-702 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-702 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ADSL adenylosuccinate lyase
ANXA6 annexin A6
APOL6 apolipoprotein L, 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF6 activating transcription factor 6
BAG1 BCL2-associated athanogene
BATF3 basic leucine zipper transcription factor, ATF-like 3
C14ORF1 chromosome 14 open reading frame 1
C1ORF95 chromosome 1 open reading frame 95
C2CD5 C2 calcium-dependent domain containing 5
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCDC40 coiled-coil domain containing 40
CD2AP CD2-associated protein
CD83 CD83 molecule
CDT1 chromatin licensing and DNA replication factor 1
CFAP70 cilia and flagella associated protein 70
CHKA choline kinase alpha
COQ3 coenzyme Q3 methyltransferase
CXCL6 chemokine (C-X-C motif) ligand 6
CYHR1 cysteine/histidine-rich 1
DAXX death-domain associated protein
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DUS2 dihydrouridine synthase 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM188A family with sequence similarity 188, member A
FAM63A family with sequence similarity 63, member A
FBXO11 F-box protein 11
FKBP8 FK506 binding protein 8, 38kDa
FOXC1 forkhead box C1
GIMAP5 GTPase, IMAP family member 5
GLUD1 glutamate dehydrogenase 1
GM2A GM2 ganglioside activator
GPR87 G protein-coupled receptor 87
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRK6 G protein-coupled receptor kinase 6
GSTT1 glutathione S-transferase theta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GYPC glycophorin C (Gerbich blood group)
HIST1H4E histone cluster 1, H4e
IDUA iduronidase, alpha-L-
ISCA1 iron-sulfur cluster assembly 1
LONRF3 LON peptidase N-terminal domain and ring finger 3
LUZP1 leucine zipper protein 1
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MED6 mediator complex subunit 6
MTSS1 metastasis suppressor 1
MYL10 myosin, light chain 10, regulatory
N4BP2L1 NEDD4 binding protein 2-like 1
NCAPH non-SMC condensin I complex, subunit H
NDRG2 NDRG family member 2
NEMF nuclear export mediator factor
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PEX16 peroxisomal biogenesis factor 16
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PKNOX2 PBX/knotted 1 homeobox 2
PLAUR plasminogen activator, urokinase receptor
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNRC1 proline-rich nuclear receptor coactivator 1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RECQL RecQ helicase-like
RNF14 ring finger protein 14
RNF24 ring finger protein 24
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RYBP RING1 and YY1 binding protein
SEZ6L seizure related 6 homolog (mouse)-like
SIK2 salt-inducible kinase 2
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC38A10 solute carrier family 38, member 10
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SREBF1 sterol regulatory element binding transcription factor 1
SRPK2 SRSF protein kinase 2
SYF2 SYF2 pre-mRNA-splicing factor
TAOK1 TAO kinase 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFCP2 transcription factor CP2
TLN1 talin 1
TOB2 transducer of ERBB2, 2
TPST1 tyrosylprotein sulfotransferase 1
TRIM33 tripartite motif containing 33
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UBAP2 ubiquitin associated protein 2
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBL3 ubiquitin-like 3
YIPF2 Yip1 domain family, member 2
YTHDC2 YTH domain containing 2
ZNF142 zinc finger protein 142
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AACS acetoacetyl-CoA synthetase
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ACVR2B activin A receptor, type IIB
ADAP2 ArfGAP with dual PH domains 2
ADAT1 adenosine deaminase, tRNA-specific 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASCC2 activating signal cointegrator 1 complex subunit 2
BBC3 BCL2 binding component 3
BPHL biphenyl hydrolase-like (serine hydrolase)
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C1ORF115 chromosome 1 open reading frame 115
CA11 carbonic anhydrase XI
CCDC176 coiled-coil domain containing 176
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDK9 cyclin-dependent kinase 9
CNTD2 cyclin N-terminal domain containing 2
CPA4 carboxypeptidase A4
CRMP1 collapsin response mediator protein 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DMTN dematin actin binding protein
DPF3 D4, zinc and double PHD fingers, family 3
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERMP1 endoplasmic reticulum metallopeptidase 1
FAM155B family with sequence similarity 155, member B
FBXO46 F-box protein 46
FBXW4 F-box and WD repeat domain containing 4
FRS3 fibroblast growth factor receptor substrate 3
G6PC2 glucose-6-phosphatase, catalytic, 2
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLI3 GLI family zinc finger 3
GPR12 G protein-coupled receptor 12
GPR21 G protein-coupled receptor 21
GSTZ1 glutathione S-transferase zeta 1
GTPBP2 GTP binding protein 2
HEBP1 heme binding protein 1
HIST1H2BC histone cluster 1, H2bc
HIST1H3G histone cluster 1, H3g
HMX1 H6 family homeobox 1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IL15RA interleukin 15 receptor, alpha
INPPL1 inositol polyphosphate phosphatase-like 1
ITGA10 integrin, alpha 10
KAT2A K(lysine) acetyltransferase 2A
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KIFC1 kinesin family member C1
KIFC3 kinesin family member C3
KLHL21 kelch-like family member 21
LHX6 LIM homeobox 6
LRRC37A3 leucine rich repeat containing 37, member A3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEFV Mediterranean fever
MEIS3P1 Meis homeobox 3 pseudogene 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MPV17 MpV17 mitochondrial inner membrane protein
NELL2 NEL-like 2 (chicken)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NXN nucleoredoxin
OCLM oculomedin
OMG oligodendrocyte myelin glycoprotein
PCSK7 proprotein convertase subtilisin/kexin type 7
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLCD1 phospholipase C, delta 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNPO pyridoxamine 5'-phosphate oxidase
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRR15L proline rich 15-like
PUS3 pseudouridylate synthase 3
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RLBP1 retinaldehyde binding protein 1
RNF113A ring finger protein 113A
RPAP2 RNA polymerase II associated protein 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDC3 syndecan 3
SH3GL1 SH3-domain GRB2-like 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SYT13 synaptotagmin XIII
TAS2R1 taste receptor, type 2, member 1
TBP TATA box binding protein
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM164 transmembrane protein 164
TRAPPC12 trafficking protein particle complex 12
UEVLD UEV and lactate/malate dehyrogenase domains
VASP vasodilator-stimulated phosphoprotein
VIPR1 vasoactive intestinal peptide receptor 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZFP36 ZFP36 ring finger protein
ZNF280A zinc finger protein 280A
ZNF629 zinc finger protein 629