alpha-estradiol-990 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the alpha-estradiol-990 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTG2 actin, gamma 2, smooth muscle, enteric
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ATAT1 alpha tubulin acetyltransferase 1
ATN1 atrophin 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C19ORF73 chromosome 19 open reading frame 73
CA11 carbonic anhydrase XI
CDC14A cell division cycle 14A
CDKL3 cyclin-dependent kinase-like 3
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIDEB cell death-inducing DFFA-like effector b
CLUAP1 clusterin associated protein 1
COMT catechol-O-methyltransferase
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTAGE5 CTAGE family, member 5
CXXC4 CXXC finger protein 4
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DSCR3 Down syndrome critical region 3
EGR3 early growth response 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FANCE Fanconi anemia, complementation group E
FHL1 four and a half LIM domains 1
FLT4 fms-related tyrosine kinase 4
GADD45B growth arrest and DNA-damage-inducible, beta
GK glycerol kinase
GK3P glycerol kinase 3 pseudogene
GM2A GM2 ganglioside activator
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSPT1 G1 to S phase transition 1
HSPB11 heat shock protein family B (small), member 11
ICAM1 intercellular adhesion molecule 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLF9 Kruppel-like factor 9
KLHL28 kelch-like family member 28
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBTD1 mbt domain containing 1
MTAP methylthioadenosine phosphorylase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFX1 nuclear transcription factor, X-box binding 1
NKX3-2 NK3 homeobox 2
NMT2 N-myristoyltransferase 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRSN2 neurensin 2
OTUD4 OTU deubiquitinase 4
PDE4DIP phosphodiesterase 4D interacting protein
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PKP3 plakophilin 3
PLK4 polo-like kinase 4
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PRKCA protein kinase C, alpha
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRA protein tyrosine phosphatase, receptor type, A
QTRT1 queuine tRNA-ribosyltransferase 1
RAB11B RAB11B, member RAS oncogene family
RBM5 RNA binding motif protein 5
RGS10 regulator of G-protein signaling 10
RGS12 regulator of G-protein signaling 12
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF126P1 ring finger protein 126 pseudogene 1
RYR2 ryanodine receptor 2 (cardiac)
SAMD9 sterile alpha motif domain containing 9
SATB2 SATB homeobox 2
SBNO2 strawberry notch homolog 2 (Drosophila)
SCGB2A2 secretoglobin, family 2A, member 2
SCLY selenocysteine lyase
SDC3 syndecan 3
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFB1 transforming growth factor, beta 1
TJAP1 tight junction associated protein 1 (peripheral)
TMEM161A transmembrane protein 161A
TMEM242 transmembrane protein 242
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNK1 tyrosine kinase, non-receptor, 1
TROVE2 TROVE domain family, member 2
TUBA3D tubulin, alpha 3d
USB1 U6 snRNA biogenesis 1
UTRN utrophin
WAS Wiskott-Aldrich syndrome
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ACADSB acyl-CoA dehydrogenase, short/branched chain
AGBL5 ATP/GTP binding protein-like 5
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARMC6 armadillo repeat containing 6
ASB7 ankyrin repeat and SOCS box containing 7
ATP13A2 ATPase type 13A2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF80 chromosome 11 open reading frame 80
C14ORF132 chromosome 14 open reading frame 132
C3ORF52 chromosome 3 open reading frame 52
CCNO cyclin O
CCNT1 cyclin T1
CD302 CD302 molecule
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLCN2 chloride channel, voltage-sensitive 2
CORO2A coronin, actin binding protein, 2A
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTAGE9 CTAGE family, member 9
CYB5R1 cytochrome b5 reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND4A DENN/MADD domain containing 4A
DGKE diacylglycerol kinase, epsilon 64kDa
DUSP8 dual specificity phosphatase 8
ECHDC2 enoyl CoA hydratase domain containing 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAAH fatty acid amide hydrolase
FAM155B family with sequence similarity 155, member B
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALK1 galactokinase 1
GMEB1 glucocorticoid modulatory element binding protein 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFT22 intraflagellar transport 22
IRF2 interferon regulatory factor 2
KIAA0513 KIAA0513
LINC00339 long intergenic non-protein coding RNA 339
LRRC61 leucine rich repeat containing 61
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD3 LY6/PLAUR domain containing 3
LYPLA2P1 lysophospholipase II pseudogene 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MT1HL1 metallothionein 1H-like 1
MVD mevalonate (diphospho) decarboxylase
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NDRG4 NDRG family member 4
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPM3 nucleophosmin/nucleoplasmin 3
OLFML3 olfactomedin-like 3
PAQR6 progestin and adipoQ receptor family member VI
PEX26 peroxisomal biogenesis factor 26
PGM1 phosphoglucomutase 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLA2G10 phospholipase A2, group X
PNPLA6 patatin-like phospholipase domain containing 6
PODXL2 podocalyxin-like 2
RBL1 retinoblastoma-like 1
RFTN1 raftlin, lipid raft linker 1
RNF25 ring finger protein 25
SCAMP5 secretory carrier membrane protein 5
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SECISBP2 SECIS binding protein 2
SGMS1 sphingomyelin synthase 1
SH2D4A SH2 domain containing 4A
SHARPIN SHANK-associated RH domain interactor
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC41A3 solute carrier family 41, member 3
SLC46A3 solute carrier family 46, member 3
SPHK1 sphingosine kinase 1
SREBF2 sterol regulatory element binding transcription factor 2
STK16 serine/threonine kinase 16
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TGFB3 transforming growth factor, beta 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM120B transmembrane protein 120B
TMEM134 transmembrane protein 134
TNRC6B trinucleotide repeat containing 6B
TTC33 tetratricopeptide repeat domain 33
WDR19 WD repeat domain 19
WRAP73 WD repeat containing, antisense to TP73
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF212 zinc finger protein 212
ZNF226 zinc finger protein 226
ZNF276 zinc finger protein 276
ZNF282 zinc finger protein 282
ZNF365 zinc finger protein 365
ZNF721 zinc finger protein 721
ZNHIT2 zinc finger, HIT-type containing 2